Understanding how patients tolerate fluid removal during kidney support in the ICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study follows adults with AKI in the ICU who are receiving CRRT with net ultrafiltration. It aims to identify factors—clinical, hemodynamic, ultrasound, perfusion, and biochemical—that predict ultrafiltration intolerance before overt hypotension occurs. No changes to treatment decisions are made by the study team; care remains with the treating clinicians. The study uses a multiparametric assessment to better understand who is at risk of intolerance during fluid removal.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Admission to an Intensive Care Unit
* Acute kidney injury according to KDIGO criteria
* Prescription of continuous renal replacement therapy (CRRT) with net ultrafiltration
* Clinical stability considered sufficient to initiate net ultrafiltration according to the treating clinical team

Exclusion Criteria:

* Chronic kidney replacement therapy prior to ICU admission
* Pregnancy
* Limitation of therapeutic effort or goals-of-care decisions at admission or during the observation period
* Inability to perform hemodynamic or perfusion assessment
* Extracorporeal membrane oxygenation (ECMO)
* Refusal to participate in the study

Where it's running

• Hospital Las Higueras de Talcahuano
  Talcahuano, Chile Recruiting
• Hospital Universitario San José de Popayán
  Popayán, Colombia Recruiting
• Hospital General de Mexico
  Mexico City, Mexico Recruiting
• Hospital Cárdio Pulmonar
  Salvador, Brazil Not yet recruiting
• Hospital Clínico Regional de Concepción
  Concepción, Chile Not yet recruiting
• Complejo Asistencial Dr. Victor Ríos Ruiz
  Los Ángeles, Chile Not yet recruiting

Study contacts

• Principal investigator: Gonzalo Ramírez-Guerrero, MD — Hospital Las Higueras de Talcahuano
• Study coordinator: Gonzalo Ramírez-Guerrero, MD
• Email: ramirezguerrero.g@gmail.com
• Phone: +56981746173

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.