Calibration of esophageal balloon catheter for patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on calibrating the esophageal balloon catheter to accurately measure esophageal pressure in patients undergoing spontaneous mechanical ventilation. The calibration process is crucial for determining transpulmonary pressure, which influences ventilator settings and patient care. The study aims to assess how the calibration process differs between mandatory and support ventilation modes, as the dynamics of thoracic forces vary significantly. By ensuring accurate pressure readings, the study seeks to improve patient outcomes in critical care settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older.
* Mechanically ventilated in spontaneous mode.
* Sedated (Richmond Agitation Sedation Scale (RASS) between -3 and -5).
* Pes catheter in situ according to the protocol used in the LUMC (Insertion of a Pes catheter is mandatory if it is suspected that te patient will be ventilated for more than 24 hrs.).

Exclusion Criteria:

* Medical condition that excludes the placement of a Pes catheter.
* Allergic reaction against rocuronium in the past.
* Pregnant.
* RASS \> -3

Where it's running

• Leiden University Medical Center
  Leiden, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Abraham Schoe, MD, PhD — Leiden University Medical Center
• Study coordinator: Willem Snoep, BSc
• Email: j.w.m.snoep@lumc.nl
• Phone: +31 (0)71-5262164

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Permissive lung-protective ventilation in invasively ventilated adults

  This study tests whether lowering the breathing rate during mechanical ventilation is better than standard lung-protective ventilation for adults in the ICU who need invasive ventilation.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, NL and 1 other locations · NCT07837128

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• How short high-oxygen exposures affect brain blood flow during mechanical ventilation

  We will test whether brief, controlled increases in ventilator oxygen change brain blood flow in adults who are intubated and on mechanical ventilation in the ICU.

  Recruiting Erasme University Hospital · Brussels · NCT07377162

• Neuromuscular electrical stimulation for patients on invasive mechanical ventilation (MOVCARE)

  We will test whether adding neuromuscular electrical stimulation to usual physical therapy helps adults on invasive mechanical ventilation regain leg muscle strength faster.

  Recruiting Hospital Moinhos de Vento · Porto Alegre, Rio Grande do Sul · NCT07188350

• Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

  We will see if surface diaphragm EMG, esophageal pressure, and oxygen use measured during a spontaneous breathing trial can predict who will fail to wean from the ventilator in the ICU.

  Recruiting Leiden University Medical Center · Leiden · NCT07109570

• Combining chest X-rays and arterial blood gas results to predict ventilator need in critically ill adults

  This project will test whether a computer model that uses chest X-rays and arterial blood gas results can predict which critically ill adults will need mechanical ventilation.

  Recruiting Zagazig University · Zagazig, Al Sharqia · NCT07001696

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.