Evaluating how well fentanyl patches work in unstable ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the absorption of fentanyl delivered via transdermal patches in critically ill surgical ICU patients. It compares two groups: hemodynamically unstable patients requiring vasopressors and stable patients not needing such support. Blood levels of fentanyl will be measured over time to assess absorption differences between the groups. The study aims to determine the viability of transdermal fentanyl for pain management in resource-limited settings or when intravenous options are unavailable.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-70 years.
* Male or female patients.
* Admitted to the surgical intensive care unit (ICU).
* Indications for pain management using fentanyl.

Exclusion Criteria:

* No clinical indication for fentanyl analgesia (e.g., pain well controlled with non-opioid medications).
* Known allergy or hypersensitivity to fentanyl.
* Contraindications to fentanyl (e.g., severe constipation, hepatic failure)
* Patients infected with multidrug-resistant organisms require high-level isolation (biosafety level 2 or higher).
* Hemodynamically very unstable patients requiring \>20 drops/hour of norepinephrine (4 mg/50 mL), with or without vasopressin support.

Where it's running

• Tel Aviv Medical Center
  Tel Aviv, Israel, Israel Recruiting

Study contacts

• Study coordinator: Avner Leshem, MD-PhD
• Email: avnerle@tlvmc.gov.il
• Phone: +972-3-6973255

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.