Predicting fluid responsiveness using PLR, PPV, and LVOT VTI in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study compares changes in pulse pressure variation and LVOT VTI-based cardiac output during a passive leg raise in mechanically ventilated ICU patients with suspected fluid deficit. No extra treatments are used beyond standard care; transthoracic echocardiography is added to routinely monitor LVOT VTI and calculate stroke volume and cardiac output. Patients are classified as fluid responsive or non-responsive based on a 10% or greater increase in LVOT VTI-based CO after PLR, and PPV changes are analyzed accordingly. The study aims to identify whether LVOT VTI measurements can improve prediction of fluid responsiveness beyond traditional PPV alone. Conducted at Izmir Katip Celebi University Atatürk Training and Research Hospital in Turkey, it seeks to inform more precise fluid-management decisions in critical care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients aged ≥18 years
2. Patients admitted to the intensive care unit receiving mechanical ventilation
3. Presence of suspected intravascular fluid deficit (hypotension, negative fluid balance, or clinical signs of peripheral hypoperfusion)
4. Patients in sinus rhythm
5. Presence of invasive arterial blood pressure monitoring
6. Adequate echocardiographic window allowing transthoracic echocardiographic measurement of LVOT VTI
7. Patients ventilated with tidal volume ≥8 mL/kg (ideal body weight)
8. Hemodynamically stable enough to allow measurement

Exclusion Criteria:

1. Patients under 18 years of age
2. Presence of atrial fibrillation or significant arrhythmias such as frequent ventricular or atrial ectopy
3. Severe right ventricular dysfunction or significant tricuspid regurgitation
4. Advanced aortic valve disease (severe stenosis or severe regurgitation)
5. Patients with significant spontaneous breathing effort
6. Patients receiving lung-protective low tidal volume ventilation strategy (\<8 mL/kg) due to ARDS
7. Inadequate echocardiographic window for LVOT VTI assessment
8. Severe hemodynamic instability during measurement (sudden vasopressor escalation or need for resuscitation)
9. Patients who refuse to participate or from whom written informed consent cannot be obtained from themselves or a first-degree relative

Where it's running

• Izmir Katip Celebi University Atatürk Training and Research Hospital İzmir, , Turkey
  Izmir, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Murat Aksun — Izmir Katip Celebi University Atatürk Training and Research Hospital
• Study coordinator: Murat Aksun, M.D.
• Email: murataksun@yahoo.com
• Phone: +90 552 363 16 14

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.