Improving nutrition in critically ill patients with gastrointestinal issues
Official title: Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction
Run by Romanian Society for Enteral and Parenteral Nutrition · NCT06510348 · Data updated 2026-11-12
This study tests if combining two types of nutrition methods can help critically ill patients with gut issues get the right amount of food they need to recover.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 164 (estimated) |
| Sponsor | Romanian Society for Enteral and Parenteral Nutrition Academic / other |
| Locations | 1 site (Bucharest) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | November 6, 2024 |
| Trial ID | NCT06510348 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 who have been on mechanical ventilation for more than four days and have impaired intestinal absorption.
✕Probably not a fit
Patients who may not benefit include those with recent gastrointestinal surgery, severe malabsorption conditions, or other significant contraindications.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of combining enteral and supplemental parenteral nutrition (SPN) to achieve nutritional targets in critically ill patients experiencing gastrointestinal dysfunction. It aims to address the challenges of providing adequate nutrition in patients who are mechanically ventilated and may have impaired absorption. The study will monitor the nutritional intake and uptake to ensure that patients receive the necessary calories and protein without the risks associated with overfeeding. By focusing on both the delivery and absorption of nutrients, the study seeks to improve patient outcomes in intensive care settings.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of complications and improve recovery times for critically ill patients.
How similar studies have gone: While some studies have explored nutritional support in critically ill patients, this specific combination of enteral and supplemental parenteral nutrition is a novel approach that has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adults (\> 18 years old) * Mechanical ventilation for more than four days, * Controlled shock state (hemodynamic and tissue perfusion goals are reached) - Impaired intestinal absorbtion, defiend by both ultrasound measurement of gastric residual volume and paracetamol absorbtion test Exclusion Criteria: * patients on non-invasive mechanichal ventilation * contraindication for EN for \> 48 h after admission * patients with gastrointestinal surgical intervention within 3 months, * history of malabsorption, inflammatory bowel disease * short bowel syndrom * anorexia nervosa * gastrointestinal bleeding * cirrhosis * traumatic brain injury * subarahnoidal hemorrhage * neoplasia * post cardiac arrest patients * patients on chronic therapy with corticosteroids * pregnant women.
Where it's running
-
Clinical Emergency Hospital of Bucharest
Bucharest, Romania Recruiting
Study contacts
- Principal investigator: Cristian Cobilinschi, MD, PhD — Bucharest Emergency Hospital
- Study coordinator: Cristian Cobilinschi, MD, PhD
- Email: cristian.cobilinschi@umfcd.ro
- Phone: +40765018776
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Gastric emptying and feeding tolerance in ICU patients by vasopressor dose
This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.
-
Predicting Extubation Problems With Machine Learning
This study tests whether computer models can predict extubation failure in adults on ventilators in the ICU.
-
Levetiracetam Dosing in Critically Ill on CRRT
This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.
-
Respiratory Physiotherapy in Critically Ill Pneumonia Patients
This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.
-
Immersive VR for improving upper limb function in critically ill ICU patients
This trial tests whether fully immersive virtual reality training added to standard ICU rehabilitation can help improve upper limb strength and coordination in adults with ICU-acquired weakness.
-
Cycling with immersive VR for ICU patients recovering from critical illness
In this crossover study, critically ill adults in the ICU will try three 10-minute cycling sessions to see if an immersive VR environment motivates them more than cycling with no visuals or cycling while watching a route on a TV.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.