6-month dietitian-guided nutrition program for patients recovering from critical illness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will enroll adults admitted to the ICU for more than 48 hours with one or more organ failures. Participants are assigned to either standard local nutrition care or to a dietitian-tailored program with frequent follow-up from inclusion through six months after admission. The dietitian group receives individualized nutrition prescriptions during hospitalization and scheduled consultations after discharge, with energy and protein intake and other outcomes collected at days 10, 30, 90, and 180. Physical performance tests and blood sampling are optional, and follow-up data are collected regardless of discharge location.

Why it matters

Who can join: the full rules

Inclusion Criteria: Patients in intensive care who gives an informed consent and meet all of the following will be eligible:

1. Admitted to the intensive care unit for \>48 hours.
2. At least 18 years of age
3. Have one or more organ system failure (respiratory,cardiovascular or renal) related to their acute illness defined as:

   a. PaO2/FiO2≤300 mm Hg) b. Currently on one or more continuous inotrope/vasopressor infusion which were started at least 4 hours ago at a minimum dose of: i. Norepinephrine≥0.1 mcg/kg/min ii. Epinephrine≥0.1 mcg/kg/min iii. Any dose of vasopressin iv. Milrinone\>0.1 mcg/kg/min) c. Renal dysfunction defined as: i. Serum creatinine 2.0-2.9 times baseline or ii. Urine output 0.5 mL/kg/hour for ≥12 hours or iii. Currently receiving renal replacement therapy) d. Currently has an intracranial pressure monitor or ventricular drain in situ
4. Permanent living address in Norway

Exclusion Criteria: Patients will be excluded if:

1. Death is imminent in the next 96 hours or there is a current treatment limitation in place or the patient is unlikely to survive to 180 days due to underlying/chronic illness
2. Dialysis dependent chronic renal failure
3. Suspected or known pregnancy
4. Wheelchair user
5. Cognitive impairment in which intervention is considered not appropriate
6. Eating disorders -

Where it's running

• University Hospital of North Norway
  Tromsø, Norway Recruiting

Study contacts

• Principal investigator: Anders Benjamin Kildal, MD, PHD — University Hospital of North Norway
• Study coordinator: Anders Benjamin Kildal, MD, PHD
• Email: anders.benjamin.kildal@unn.no
• Phone: +47 77798928

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.