Understanding how blood vessel control affects critically ill patients
Official title: Tie2-driven vascular control in critical illness
Funded at Ut Southwestern Medical Center · NIH-10983537 · Data updated 2026-11-12
This study is looking at how a specific protein called Angiopoietin-2 affects blood vessel responses during sepsis, a serious infection, to help doctors predict outcomes and improve care for patients in intensive care, while also exploring genetic factors that might help tailor treatments for individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 16, 2018 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $93,057 |
| NIH project number | 3R35HL139424-07S1 |
| Project ID | NIH-10983537 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients diagnosed with sepsis or at risk of developing sepsis.
✕Less likely to help
Patients with non-sepsis-related critical illnesses or those who are not critically ill may not benefit from this research.
What this research studies
This research investigates the role of the Tie2 receptor and its ligands, particularly Angiopoietin-2, in the vascular response to sepsis, a severe infection that can lead to multi-organ failure. By measuring Angiopoietin-2 levels in patients, the study aims to predict adverse outcomes and improve patient care in intensive care settings. The research also explores genetic factors that may influence how well an individual's blood vessels respond to the stress of sepsis, potentially leading to personalized treatment approaches. Overall, the goal is to develop new strategies to manage sepsis and its complications effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for critically ill patients suffering from sepsis, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promise in targeting vascular responses in sepsis, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Parikh, Samir M — Ut Southwestern Medical Center
- Study coordinator: Parikh, Samir M
Related research
Other NIH-funded projects on the same topics.
-
Glucocorticoids and critical illness outcomes in ICU patients
A researcher team at Columbia University will study how glucocorticoids affect short- and long-term outcomes for people who survive critical illness, including mental health and recovery aspects.
-
REPAIR-ICU: Understanding aging-like changes after critical illness to help ICU survivors
This grant studies how surviving an ICU stay triggers aging-related changes in the body and tests interventions to help people recover.
-
Understanding how individual responses to treatments vary in ARDS and sepsis
This grant aims to help clinicians predict which patients with ARDS or sepsis will benefit most from specific treatments by using advanced computer approaches.
-
Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis
Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.
-
Molecular rules of capillary leak in seriously ill kids
A study looking at why blood vessels become leaky in severely ill children and how that leads to organ failure.
-
Heme-Driven Immune Dysregulation in Critical Illness
Researchers are studying how free heme from red blood cell breakdown affects the immune system in people with sepsis or chronic blood disorders, with the aim of guiding better treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.