Understanding how blood vessel control affects critically ill patients
Tie2-driven vascular control in critical illness
This study is looking at how a specific protein called Angiopoietin-2 affects blood vessel responses during sepsis, a serious infection, to help doctors predict outcomes and improve care for patients in intensive care, while also exploring genetic factors that might help tailor treatments for individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10983537 on NIH RePORTER |
What this research studies
This research investigates the role of the Tie2 receptor and its ligands, particularly Angiopoietin-2, in the vascular response to sepsis, a severe infection that can lead to multi-organ failure. By measuring Angiopoietin-2 levels in patients, the study aims to predict adverse outcomes and improve patient care in intensive care settings. The research also explores genetic factors that may influence how well an individual's blood vessels respond to the stress of sepsis, potentially leading to personalized treatment approaches. Overall, the goal is to develop new strategies to manage sepsis and its complications effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients diagnosed with sepsis or at risk of developing sepsis.
Not a fit: Patients with non-sepsis-related critical illnesses or those who are not critically ill may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for critically ill patients suffering from sepsis, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promise in targeting vascular responses in sepsis, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Parikh, Samir M — Ut Southwestern Medical Center
- Study coordinator: Parikh, Samir M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.