Condition

Acute Kidney Injury clinical trials and research

• 121Clinical trials
• 96NIH research projects
• 1New in 30 days
• 38Countries

Newest Acute Kidney Injury clinical trials

All recruiting trials (121)

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

• Perioperative GFR Monitoring to Predict CSA-AKI and CA-AKI

  This study tests whether perioperative transcutaneous fluorescence GFR measurements can predict CSA-AKI or CA-AKI in adults undergoing cardiovascular procedures or iodine contrast exposure.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07749417

• Restarting RAS inhibitors after AKI: a quick test in hospitalized adults

  This pilot study tests whether restarting renin-angiotensin system inhibitors early after acute kidney injury is feasible and safe in hospitalized adults already using these medicines.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07734636

• FST Decision Support to Help Timely Therapy for Kids with AKI Risk

  This study tests whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe AKI.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07718464

• Infliximab plus prednisone vs prednisone alone for ICI-associated AKI

  This study tests whether adding infliximab to prednisone helps adults with kidney injury caused by cancer immunotherapy recover kidney function faster than standard prednisone alone.

  Recruiting at 2 sites Phase 4 Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT07683975

• Acute Kidney Injury in Care Transitions: A Practical Trial

  This trial tests whether a multidisciplinary care-transition program helps adults with moderate to severe AKI improve outcomes after hospital discharge.

  Recruiting Mayo Clinic · Mankato, Minnesota and 2 other locations · NCT07670520

• Understanding how patients tolerate fluid removal during kidney support in the ICU

  This observational study tests how well critically ill adults with acute kidney injury tolerate net fluid removal during continuous renal replacement therapy.

  Recruiting at 3 sites Hospital Las Higueras · Salvador and 9 other locations · NCT07643597

• Renal perfusion during minimally invasive abdominal surgery using ultrasound and NIRS

  Researchers will test if Doppler ultrasound RRI and NIRS-based rSO₂ can detect changes in kidney perfusion during elective laparoscopic surgery in adults with varying health status.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07635160

• Initial drainage method for a solitary kidney stone causing kidney failure

  This trial tests whether placing a JJ stent or a nephrostomy tube first helps when a single kidney is blocked by a stone, followed by a standard stone-removal procedure.

  Recruiting at 3 sites Beni-Suef University · Banī Suwayf, Beni Suweif Governorate and 2 other locations · NCT07627880

• Coordinated Communication, Education, and Care Transitions After Acute Kidney Injury (CONNECT-AKI)

  This study tests whether a discharge summary template and a chat-based education program help adults with AKI understand their condition and follow up after leaving the hospital.

  Recruiting at 2 sites Northwell Health · Glen Oaks, New York and 1 other locations · NCT07626268

• Relaxin agonist R2R01 in high-risk heart-surgery patients

  This Phase 2 study tests whether the relaxin agonist R2R01 can help prevent acute kidney injury in adults undergoing non-emergency heart or aorta surgery with cardiopulmonary bypass.

  Recruiting Phase 2 River 2 Renal Corp. · Milan · NCT07625553

• Aminophylline in the Bladder to Help Place a Ureteral Stent Quickly

  This study tests whether putting aminophylline into the bladder before stenting helps adults with acute kidney blockage due to stones see if a ureteral stent can be placed more easily and quickly.

  Recruiting Phase 2 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07617948

• Better follow-up and testing after acute kidney injury

  This project will test different blood tests, a measured kidney clearance, body measurements, and patient interviews to see which best help adults recovering from hospitalised acute kidney injury.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT07569588

• Which antibiotic combo is safer for kidneys in serious hospital infections

  This trial tests whether vancomycin with piperacillin/tazobactam is gentler on the kidneys than other common broad-spectrum antibiotics for adults with serious infections in the hospital.

  Recruiting at 5 sites Phase 4 Bassett Healthcare · Worcester, Massachusetts and 6 other locations · NCT07556107

• Transcutaneous auricular vagus nerve stimulation to prevent kidney injury after heart surgery

  This trial tests whether applying a non-invasive ear stimulation (taVNS) around the time of elective heart surgery can help prevent acute kidney injury in adults undergoing cardiopulmonary bypass.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07549243

• Citrate anticoagulation protocol to stabilize electrolytes during continuous renal replacement in ICU adults

  This test tries to see if a modified CRRT method using citrate anticoagulation with post-filter replacement keeps electrolytes more stable and reduces the need for supplements in adult ICU patients with acute kidney injury.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona, Barcelona · NCT07514650

• Creatine for thinking and kidney stress after exercising in the heat

  We will test if one week of creatine supplements helps protect kidney markers and preserve thinking skills in healthy, active adults after exercising in hot conditions.

  Recruiting University of Northern Iowa · Cedar Falls, Iowa · NCT07472426

• Sodium bicarbonate for critically ill patients with metabolic acidosis and AKI

  This trial tests whether giving sodium bicarbonate helps reduce major kidney problems 90 days later in adults with septic or critical illness and kidney injury.

  Recruiting Phase 4 Universität Münster · Münster · NCT07464431

• Postoperative acute kidney injury in children after major non-cardiac surgery

  This international observational study will test whether urinary biomarkers can help predict postoperative acute kidney injury in hospitalized children (0–16 years) undergoing major non-cardiac surgery.

  Recruiting at 6 sites Uppsala University · Perth, Western Australia and 15 other locations · NCT07351149

• Hamburg Acute Renal Injury (HARIS) cohort

  This project will follow adults hospitalized with AKI and a group of similar hospitalized patients without AKI to test which clinical factors and blood or urine markers predict recovery and longer-term kidney and cardiovascular problems.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07338669

• PrismaLung+ carbon dioxide removal for ventilated ICU patients

  This study will test whether adding PrismaLung+, a device that removes CO2 from the blood, helps adults on invasive mechanical ventilation who have high carbon dioxide levels.

  Recruiting at 9 sites Vantive Health LLC · Beijing, Beijing Municipality and 9 other locations · NCT07326215

• Using the SGLT2 pill dapagliflozin for hospitalized adults with heart failure who develop acute kidney injury.

  This trial will test whether adding the SGLT2 pill dapagliflozin to usual care helps hospitalized adults with heart failure who develop acute kidney injury.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07273838

• Epidemiology and care for dialysis in ICU patients with severe acute kidney injury in Latin America

  This project will collect and compare data on adults in ICUs across Latin America who need dialysis for severe acute kidney injury to see how they are treated and what outcomes they have.

  Recruiting at 8 sites University of Alabama at Birmingham · Cochabamba and 14 other locations · NCT07262320

• VExUS ultrasound-guided fluid management during thoracic surgery with one-lung ventilation

  This trial will test whether using a VExUS ultrasound-guided goal-directed fluid plan during thoracic surgery with one-lung ventilation reduces postoperative lung complications and acute kidney injury.

  Recruiting University of Crete · Heraklion, Crete · NCT07258875

• Iron-chelator added to dialysis fluid in sepsis-related AKI on CRRT

  In adults with sepsis-associated acute kidney injury requiring dialysis, this study tests whether adding the iron-binding drug MEX-CD1 to dialysis fluid helps remove more iron compared with standard dialysis fluid.

  Recruiting Phase 1/2 Centre Hospitalier Universitaire de Nīmes · Nîmes, Gard and 1 other locations · NCT07236463

• Flozins to prevent contrast-related kidney injury after coronary angiography or PCI

  This project tests whether taking a flozin (empagliflozin or dapagliflozin), short-term or long-term, lowers the chance of contrast-induced acute kidney injury in patients having coronary angiography or PCI.

  Recruiting Collegium Medicum w Bydgoszczy · Bydgoszcz · NCT07231939

• Cilastatin versus thiosulfate for protecting kidneys during ovarian cancer debulking with cisplatin HIPEC

  This trial tests whether cilastatin works as well as thiosulfate at protecting the kidneys in adult women having debulking surgery with intraoperative cisplatin HIPEC.

  Recruiting Phase 2 Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07229040

• AZD4144 for sepsis-associated acute kidney injury

  This will test whether IV AZD4144 given once daily can help adults with sepsis who recently developed acute kidney injury.

  Recruiting at 48 sites Phase 2 AstraZeneca · Phoenix, Arizona and 73 other locations · NCT07215702

• Amino acid infusion after heart surgery to protect kids’ kidneys

  This study tests whether giving an amino acid infusion during and after pediatric heart surgery can lower the chance of acute kidney injury and reduce time on a ventilator, compared with a placebo.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07212595

• Cystatin C for early detection of contrast-induced acute kidney injury

  We will test whether a blood test called cystatin C can detect contrast-induced acute kidney injury sooner than standard creatinine tests in adults with chronic kidney disease having contrast CT scans or coronary angiography.

  Recruiting at 4 sites BayCare Health System · Clearwater, Florida and 3 other locations · NCT07197957

• New kidney biomarkers to predict kidney injury after radical nephrectomy

  We will test whether measuring new kidney biomarkers before, during, and after radical nephrectomy can help predict acute kidney injury and one-year chronic kidney disease in adults having the operation.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07088874

• Using kidney Doppler and urine oxygen to predict acute kidney injury after open heart surgery

  This tests whether kidney Doppler measurements and urine oxygen levels can predict acute kidney injury in adults having elective on-pump open heart surgery.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07037485

• Renal assist device to protect kidney function during on-pump heart surgery

  This study will try a temporary Renal Assist Device during on-pump coronary artery bypass or valve surgery to help adults with weakened kidneys (eGFR 15–60) keep kidney function after the operation.

  Recruiting at 6 sites 3ive Labs · Weston, Florida and 6 other locations · NCT07017933

• Choosing Wisely recommendations for care in the intensive care unit

  This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07013175

• Using ultrasound to prevent and treat kidney injury after heart surgery

  This study is testing if using ultrasound to check for fluid buildup in the liver and kidneys can help prevent and treat kidney problems after heart surgery.

  Recruiting Onassis Cardiac Surgery Centre · Athens, Kallithea · NCT06972082

• Amimestrocel (umbilical cord mesenchymal stromal cells) for acute kidney injury

  This trial tests whether Amimestrocel (umbilical cord mesenchymal stromal cells) can help adults aged 18–75 with acute kidney injury recover kidney function while monitoring safety.

  Recruiting at 5 sites Phase 2 Chinese PLA General Hospital · Beijing, Beijing Municipality and 5 other locations · NCT06954740

• Comparing kidney risk of vancomycin with piperacillin-tazobactam versus vancomycin with cefepime in hospitalized adults

  This study will test whether combining vancomycin with piperacillin-tazobactam causes about the same risk of acute kidney injury as combining vancomycin with cefepime in hospitalized adults with suspected or confirmed infection.

  Recruiting Phase 4 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06954129

• Modeling kidney injury caused by drugs

  This study is trying to find a way to predict kidney problems in patients who have had kidney injury from medications to help understand how different drugs affect their recovery.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06939387

• Using droxidopa to improve kidney function in patients with liver cirrhosis and kidney injury

  This study is testing if an oral medication called droxidopa can help improve kidney function and blood pressure in hospitalized patients with liver cirrhosis and kidney injury.

  Recruiting Phase 2 Columbia University · New York, New York · NCT06937307

• Analyzing prognosis and risk factors for acute kidney injury

  This study is testing how severe acute kidney injury affects adults' long-term health and financial well-being by looking at their medical records and blood test results.

  Recruiting Seoul National University Hospital · Seoul · NCT06898944

• Using cilastatin to prevent kidney damage from certain hospital medications

  This trial will test whether cilastatin can prevent acute kidney injury in hospitalized adults receiving certain kidney-harming medications.

  Recruiting at 2 sites Phase 2 University of Calgary · Calgary, Alberta and 1 other locations · NCT06886464

• Effects of hemoglobin levels on kidney injury after emergency surgery

  This study is testing if having higher hemoglobin levels before emergency surgery can help prevent kidney injury in patients after the operation.

  Recruiting Samsun University · Samsun · NCT06857630

• AI decision support to help emergency doctors detect and manage acute kidney injury

  This project will test whether an AI-based tool helps emergency doctors find and manage acute kidney injury earlier in adults who have blood creatinine measured during their ED visit.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06840210

• Amino acid supplementation for patients undergoing kidney dialysis

  This study tests if giving extra amino acids to patients on kidney dialysis can improve their health while they are in the ICU.

  Recruiting Karolinska University Hospital · Stockholm · NCT06835816

• Monitoring system to predict kidney injury after heart surgery

  This study is testing a new monitoring system to see if it can help predict and prevent kidney injury in adults and infants undergoing heart surgery.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milano · NCT06786416

• Using ultrasound to guide treatment for heart failure patients

  This study is testing if using ultrasound to guide treatment can help hospitalized heart failure patients feel better by managing fluid buildup in their bodies.

  Recruiting Oslo University Hospital · Oslo · NCT06714409

• Predicting successful weaning from continuous renal replacement therapy in acute kidney injury patients

  This study is testing if changes in a specific blood marker can help doctors know the best time to stop kidney support treatment in patients with acute kidney injury.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 2 other locations · NCT06714214

• Preoperative albumin treatment to prevent kidney injury in young heart surgery patients

  This study tests if giving a protein called albumin to young children with low levels before heart surgery can help prevent kidney problems after the operation.

  Recruiting Seoul National University Hospital · Seoul, Seoul · NCT06710353

• Preventing kidney injury after heart surgery with a proton pump inhibitor

  This study is testing if giving the heart surgery patients a medication called pantoprazole can help prevent kidney injuries after their surgery.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06706258

• Using MRI to study kidney disease and its complications

  This study is testing if a special type of MRI can help find out more about kidney problems and their effects on heart health in people with acute kidney injury and chronic kidney disease.

  Recruiting University of Edinburgh · Edinburgh · NCT06698614

• Early versus standard continuous dialysis for adults with cardiogenic shock on VA‑ECMO

  We will test whether starting continuous dialysis earlier helps adults with cardiogenic shock and moderate-to-severe acute kidney injury who are on veno-arterial ECMO, compared with the usual timing.

  Recruiting Phase 4 Samsung Medical Center · Seoul and 1 other locations · NCT06696235

• AI software predicting acute kidney injury in ICU patients

  This study is testing whether a new AI tool can help doctors predict and prevent kidney problems in ICU patients by alerting them when someone is at high risk.

  Recruiting Huede Healthtech Co., Ltd. · Taichung · NCT06685367

• Using donor adipose-derived stem cells to prevent worsening after trauma-related acute kidney injury

  This trial will test whether three doses of donated adipose-derived mesenchymal stem cells can prevent progression of moderate-to-severe trauma-related acute kidney injury in hospitalized adults.

  Recruiting Phase 1/2 Hope Biosciences Research Foundation · Birmingham, Alabama and 2 other locations · NCT06654193

• Understanding kidney disease in people with cystic fibrosis

  This study looks at how cystic fibrosis affects kidney health by checking blood and urine samples to help find ways to spot and prevent kidney problems early.

  Recruiting at 3 sites University of Virginia · Birmingham, Alabama and 2 other locations · NCT06595420

• Virtual home hospital care with remote monitoring for acute kidney injury

  This study is testing whether virtual care and remote monitoring can help adults with acute kidney injury recover better at home and avoid going back to the hospital.

  Recruiting at 2 sites University of Calgary · Calgary, Alberta and 1 other locations · NCT06537453

• Effect of Albumin on Kidney Function After Liver Transplant

  This study is testing if giving extra albumin to liver transplant patients can help prevent kidney problems after their surgery.

  Recruiting at 8 sites Phase 4 Rennes University Hospital · Chambray-lès-Tours and 7 other locations · NCT06535945

• Comparing early proton pump inhibitor use to standard care for kidney injury in trauma patients

  This study is testing if giving the heartburn medication pantoprazole early can help prevent kidney injury in trauma patients who are in shock.

  Recruiting Phase 2/3 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06531642

• Using SGLT2 inhibitors to treat acute kidney disease

  This study is testing whether SGLT2 inhibitors can help people with acute kidney disease by reducing protein in their urine and improving kidney health.

  Recruiting Phase 2 National Taiwan University Hospital · Taipei · NCT06528405

• Evaluating fluid treatment strategies for kidney injury in cirrhosis patients

  This study is testing two different ways to give IV fluids to people with kidney injury and cirrhosis to see which method helps them feel better and survive longer.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06525623

• Registry for pediatric patients with acute kidney injury due to sepsis receiving QUELIMMUNE

  This study is looking to see if a treatment called QUELIMMUNE is safe for kids with kidney injury from sepsis and if it helps reduce new infections compared to those getting standard kidney treatment.

  Recruiting at 15 sites SeaStar Medical · Birmingham, Alabama and 14 other locations · NCT06517810

• Measuring tissue oxygen levels during surgery for ovarian cancer

  This study is testing if low oxygen levels in muscle during surgery for ovarian cancer can lead to kidney problems afterward in women undergoing treatment.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT06475261

• Investigating nephroprotective measures for critically ill patients with acute kidney injury

  This study looks at how well hospitals follow guidelines to protect the kidneys of critically ill patients with moderate to severe acute kidney injury to see if it can help improve their care.

  Recruiting at 3 sites Universität Münster · Innsbruck and 2 other locations · NCT06472999

• Comparing low and standard dose-intensity continuous renal replacement therapy in critically ill patients

  This study is testing if a lower dose of kidney treatment is just as good as the standard dose for critically ill patients with acute kidney injury.

  Recruiting at 10 sites University of Alberta · Rochester, Minnesota and 9 other locations · NCT06446739

• Carvedilol plus simvastatin versus carvedilol alone for cirrhosis-related heart dysfunction

  This trial will test whether adding simvastatin to carvedilol helps adults with cirrhosis and cirrhotic cardiomyopathy reduce liver decompensation and improve survival.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT06431919

• Using renal resistive index to predict acute kidney injury in high-risk patients

  This study is testing if measuring kidney blood flow using ultrasound can help doctors spot acute kidney injury earlier in high-risk patients in the intensive care unit.

  Recruiting Aswan University · Aswān, Aswan Governorate · NCT06386796

• Comparing two dialysis techniques for kidney injury in ICU patients

  This study is testing whether a new dialysis method using citrate is just as good as a traditional method using heparin for helping ICU patients with kidney injury lower their urea levels.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06369064

• Using pulsatile blood flow during heart surgery to prevent kidney injury

  This study tests if using a pulsing blood flow during heart surgery can help protect the kidneys from injury better than the usual steady flow.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06349577

• Investigating risk factors for kidney injury in lung surgery patients

  This study is trying to find out what factors might lead to kidney problems in patients having lung surgery for cancer.

  Recruiting Atatürk Chest Diseases and Chest Surgery Training and Research Hospital · Ankara, Keçiören · NCT06341933

• Using contrast-enhanced ultrasound to assess kidney function in ICU patients

  This study is testing whether a special type of ultrasound can help doctors understand kidney function better in ICU patients with acute kidney injury.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT06341062

• Reducing surgical bleeding in adults with advanced or acute kidney disease

  This trial will test whether giving tranexamic acid or desmopressin before noncardiac surgery reduces bleeding in adults with advanced chronic kidney disease or recent acute kidney injury, including those on dialysis.

  Recruiting at 2 sites Phase 3 Hamilton Health Sciences Corporation · London, Ontario and 2 other locations · NCT06337838

• Non-invasive prediction of low blood pressure during surgery

  This study tests a new tool that helps doctors predict low blood pressure during long surgeries to keep patients safer and reduce complications.

  Recruiting University of Giessen · Giessen · NCT06291714

• Guided fluid removal using VeXUS score for patients with acute kidney injury after heart surgery

  This study is testing if using the VeXUS score to manage fluid levels can help patients with acute kidney injury after heart surgery recover better than standard care.

  Recruiting Hospices Civils de Lyon · Bron, Bron and 1 other locations · NCT06251713

• Investigating how vasopressor therapy affects kidney blood flow in septic shock patients

  This study is testing how two medications, vasopressin and angiotensin II, affect blood flow to the kidneys in patients with septic shock and kidney problems.

  Recruiting King's College Hospital NHS Trust · London · NCT06234592

• Using furosemide to assess kidney recovery in critically ill patients on dialysis

  This study is testing if a special kidney stress test using furosemide can give better information about kidney recovery for critically ill adults on dialysis compared to standard care.

  Recruiting Phase 4 Chiang Mai University · Chiang Mai · NCT06229990

• Evaluating a new biomarker for early kidney injury detection

  This study is testing if a new urine test can help doctors spot early signs of kidney injury in critically ill patients before traditional tests do.

  Recruiting Universität des Saarlandes · Homburg, Saarland · NCT06180551

• Using HA380 blood filter in critically ill patients needing extracorporeal support

  This study is testing whether a new blood filter can help critically ill patients on dialysis or ECMO recover faster by reducing inflammation and improving their overall care.

  Recruiting University Hospitals, Leicester · Leicester, Leicestershire · NCT06179771

• Measuring kidney blood flow changes in critically ill patients on dialysis.

  This study is testing if measuring kidney blood flow changes can help doctors spot kidney problems earlier in critically ill patients on dialysis.

  Recruiting Uniwersytecki Szpital Kliniczny w Opolu · Opole, Opole Voivodeship · NCT06174610

• Evaluating kidney and blood pressure outcomes in childhood cancer survivors

  This study is trying to see how common kidney problems and high blood pressure are in childhood cancer survivors a few years after their treatment.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06153147

• Comparing two methods of renal replacement therapy for patients on ECMO

  This study is testing two different ways to provide kidney treatment for patients on ECMO to see which method causes fewer complications like infections and bleeding.

  Recruiting at 9 sites Hospices Civils de Lyon · Bordeaux and 11 other locations · NCT06038162

• Monitoring kidney transplant rejection using blood DNA analysis

  This study is testing whether a new blood test that looks at DNA from the donor can help kidney transplant patients and their doctors better understand if the transplant is being rejected without needing painful biopsies.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06026592

• Comparing standard and low-dose continuous renal replacement therapy for acute kidney injury

  This study tests whether using a standard dose or a lower dose of a kidney treatment can help critically ill patients with acute kidney injury recover better.

  Recruiting at 2 sites Universität Münster · Münster and 1 other locations · NCT06021288

• Using biomarkers and electronic scores to predict kidney injury in hospitalized patients

  This study is testing if combining blood and urine tests with a new computer risk score can better predict which hospitalized patients are at high risk for serious kidney injury.

  Recruiting at 2 sites University of Chicago · Chicago, Illinois and 1 other locations · NCT05988658

• Using hypertonic saline to prevent kidney injury after heart transplantation

  This study is testing if a special salt solution can help prevent kidney problems in people who are having heart transplants.

  Recruiting Phase 2 University of Sao Paulo General Hospital · São Paulo · NCT05909150

• Ultra-low contrast coronary angiography for patients with acute kidney injury

  This study will test whether using very small amounts of contrast dye during coronary angiography is safe for hospitalized patients who have acute kidney injury.

  Recruiting at 2 sites Phase 3 Tulane University · New Orleans, Louisiana and 1 other locations · NCT05906758

• Using LSALT peptide to prevent kidney injury in heart surgery patients

  This study is testing if a new peptide can help prevent kidney injury in patients having heart surgery.

  Recruiting at 4 sites Phase 2 Arch Biopartners Inc. · Calgary, Alberta and 8 other locations · NCT05879432

• Kidney oxygen monitoring with near-infrared light during lung transplant surgery

  This project tests whether watching kidney oxygen levels with near-infrared light during lung transplant surgery can help predict which adults will develop postoperative acute kidney failure.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT05836922

• Using remote ischemic preconditioning to prevent kidney injury in septic patients

  This study is testing if a special technique that temporarily restricts blood flow in the arm can help prevent kidney injury in critically ill patients with sepsis.

  Recruiting Universität Münster · Münster · NCT05830669

• Investigating the role of angiopoietins in cardiac surgery outcomes

  This study is trying to see if measuring certain proteins in the blood can help predict complications for adults having heart surgery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05817929

• Managing fluid overload in ICU patients with acute kidney injury

  This study tests a new way to manage extra fluid in ICU patients with kidney problems to see if it helps them recover better and have fewer complications.

  Recruiting at 13 sites Hospices Civils de Lyon · Ajaccio and 13 other locations · NCT05817539

• Using digital tools to improve care after acute kidney injury

  This study is testing a new way to improve care for patients recovering from acute kidney injury by creating personalized care plans that help them transition smoothly after leaving the hospital.

  Recruiting at 2 sites University of Alberta · Calgary, Alberta and 1 other locations · NCT05806645

• Improving care for hospitalized patients with acute kidney injury

  This study is testing whether a new approach to care, which includes extra support from doctors, nurses, and pharmacists, can help hospitalized patients with acute kidney injury have more days at home after leaving the hospital.

  Recruiting at 9 sites University of Pittsburgh · Birmingham, Alabama and 8 other locations · NCT05805709

• Using a device to deactivate immune cells in patients with acute kidney injury

  This study is testing if a new device can help improve survival for patients with severe kidney injury who need ongoing kidney treatment.

  Recruiting at 24 sites SeaStar Medical · Birmingham, Alabama and 35 other locations · NCT05758077

• Using advanced imaging to analyze kidney biopsies for better diagnosis of kidney conditions

  This study is testing a new imaging technique to see if it can help doctors diagnose kidney problems more accurately and quickly in adults who need a biopsy.

  Recruiting Centre Hospitalier William Morey - Chalon sur Saône · Chalon-sur-Saône, Saône-et-Loire · NCT05728216

• Investigating kidney injury related to sepsis

  This study looks at how sepsis affects kidney function and energy use in patients with kidney injury compared to healthy people having surgery.

  Recruiting University Hospital of North Norway · Tromsø, Troms · NCT05694624

• Investigating the impact of a toxin on heart and blood vessel function during acute kidney injury

  This study is testing how a harmful toxin that builds up during kidney injury might affect heart and blood vessel function in people with acute kidney injury.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05659589

• Using blood conservation technique during heart surgery to assess kidney function

  This study is testing if a blood-saving technique during heart surgery can help improve kidney function in patients while also reducing the need for blood transfusions.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT05349292

• TIPS treatment for patients with cirrhosis and acute kidney injury

  This study is testing if a procedure called TIPS can help people with liver cirrhosis and kidney problems feel better compared to standard treatments.

  Recruiting at 10 sites Jena University Hospital · Aachen and 13 other locations · NCT05346393

• Optimizing blood flow during heart surgery

  This study is trying to see if using a pulsing blood flow during heart surgery helps patients recover better and have fewer problems with their organs compared to a steady flow.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05344573

• Understanding the molecular causes and risks of kidney and related diseases

  This study is trying to understand the genetic and environmental factors that cause kidney diseases and their complications to help improve treatment and care for people at risk or already diagnosed.

  Recruiting University Hospital, Toulouse · Toulouse · NCT05318196

• Goal-directed blood pressure, fluid, and urine management to prevent kidney injury after kidney removal

  This will try a targeted plan of fluids, medicines, and forced urine output during surgery to see if it reduces acute kidney injury in adults having a radical nephrectomy or nephroureterectomy.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT05149196

• Using melatonin to prevent kidney injury in hospitalized patients

  This study is testing if melatonin can help prevent kidney injury in hospitalized patients who are receiving antibiotic treatment.

  Recruiting at 2 sites Phase 3 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT05084196

• Using remote ischemic preconditioning to protect kidneys and heart in heart failure patients

  This study is testing if a special treatment called remote ischemic preconditioning can help protect the kidneys and heart of heart failure patients during cardiac procedures.

  Recruiting at 3 sites Phase 2/3 VA Office of Research and Development · Pittsburgh, Pennsylvania and 2 other locations · NCT04982419

• Comparing two methods of anticoagulation in kidney treatment

  This study is testing whether using a citrate infusion or a calcium-free dialysate during kidney dialysis can help prevent complications and make treatment safer for patients with acute kidney injury.

  Recruiting Groupe Hospitalier Sud Ile-de-France · Melun · NCT04968587

• Understanding brain health in ICU patients with kidney injury

  This study looks at how kidney injury affects brain health in critically ill adults in the ICU to see if measuring brain oxygen levels can help predict long-term thinking and memory problems.

  Recruiting Queen's University · Kingston, Ontario · NCT04722939

• Using albumin to improve recovery in critically ill patients with acute kidney injury

  This study is testing whether giving critically ill patients with acute kidney injury a special type of albumin instead of regular saline can help them recover better and need less kidney treatment.

  Recruiting at 9 sites Phase 4 Ottawa Hospital Research Institute · Calgary, Alberta and 15 other locations · NCT04705896

• Monitoring physiologic signals in cardiovascular surgery patients

  This study is testing whether monitoring certain health signals during heart surgery can help doctors understand and prevent kidney problems and high pressure in the abdomen in patients.

  Recruiting at 6 sites Potrero Medical · Los Angeles, California and 8 other locations · NCT04669548

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Using blood purification therapy for critically ill patients

  This study is trying to see which critically ill patients can benefit the most from a special blood purification treatment to help improve their recovery from serious conditions like kidney injury and sepsis.

  Recruiting Careggi Hospital · Florence · NCT04580680

• Understanding kidney toxicity from Cisplatin in cancer patients

  This study is testing how Cisplatin, a common chemotherapy drug, affects kidney health in both adult and child cancer patients to find early signs of kidney damage and improve treatment outcomes.

  Recruiting The Hospital for Sick Children · London, Ontario · NCT04442516

• Improving care for children with acute kidney injury using mobile health tools

  This study is trying to see if using mobile health tools can help families and doctors better manage kidney injury in children and improve their care.

  Recruiting Duke University · Durham, North Carolina · NCT04403633

• Using Shear Wave Elastography to Identify Acute Kidney Injury

  This study is testing a new imaging technique to see if it can help identify kidney injury in people who have had vascular surgery compared to healthy individuals.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT04144894

• Evaluating blood purification therapies in critically ill patients

  This study is testing if certain blood purification treatments can help critically ill patients with kidney problems or multiple organ failure feel better and recover faster.

  Recruiting at 15 sites Careggi Hospital · Empoli, Firenze and 14 other locations · NCT04033224

• Investigating inflammatory factors in acute kidney injury among ICU patients

  This study is trying to see if certain inflammation markers can help us understand why some ICU patients develop acute kidney injury, especially those with sepsis or who have had major surgery.

  Recruiting Uppsala University · Uppsala, Uppsala County · NCT03720860

• Timing of kidney treatment in critically ill patients

  This study is trying to find out if starting kidney treatment earlier can help critically ill patients with kidney injury feel better and have better outcomes.

  Recruiting Karolinska University Hospital · Stockholm · NCT03629977

• Managing blood pressure to prevent kidney injury after heart surgery

  This study tests if managing blood pressure more carefully during heart surgery can help prevent kidney problems afterwards.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT03629418

• Can Timps2 and IGFBP7 Urine Test Help Flag High-Risk AKI in Septic Shock Patients

  This study tests whether a urine test called Nephrocheck, which measures TIMP2 and IGFBP7, can identify septic shock patients at higher risk of progressing to severe acute kidney injury.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT03547414

• Comparing sodium levels in dialysis for ICU patients with kidney injury

  This study is testing if using a lower sodium level in dialysis can help ICU patients with kidney injury feel more stable and avoid extra fluid buildup.

  Recruiting Phase 2 University Hospital, Montpellier · Montpellier, Montpellier · NCT03329313

• Nationwide evaluation of acute kidney injury in hospitalized patients in China

  This study looks at how common acute kidney injury is in hospitalized patients in China and what factors might increase the risk of developing it.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT03054142

NIH-funded research (newest 40 of 96)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SEAK Alliance: Improving Care for AKI Patients in the Southeast

  A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11518282

• AKI-related delirium after heart surgery

  This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.

  NIH research University of Iowa · Iowa City, United States · NIH-11477480

• Better ways to identify types of sudden kidney injury in U.S. Veterans

  Researchers are looking for genetic and health patterns that define different types of sudden severe kidney injury in Veterans to help guide future care.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11459049

• Neuroimmune control of kidney injury using noninvasive ultrasound

  A new approach uses targeted ultrasound to gently stimulate nerves and immune signals to help the kidney recover after injury.

  NIH research University of Virginia · Charlottesville, United States · NIH-11449889

• Structure-based approach to prevent kidney injury from polymyxin use

  Aims to block how polymyxin damages the kidney so it can be used more safely to treat hard-to-kill infections.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11440389

• Using smart computer predictions to prevent kidney injury after heart surgery

  A machine-learning approach uses routinely collected hospital data to predict who might develop acute kidney injury after heart surgery, so clinicians can act early.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11417314

• Norepinephrine vs phenylephrine to reduce kidney injury after major non-cardiac surgery

  A large, real-world trial will compare two common vasopressors to see which helps prevent kidney injury after major non-heart surgeries.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11400034

• Heat and kidney injury: how heat exposure in daily life affects kidney health

  A study at Emory will look at how hot weather and heat exposure relate to sudden kidney injury and why some cases happen outside hospitals.

  NIH research Emory University · Atlanta, United States · NIH-11396997

• O'Brien Center for Acute Kidney Injury Research: Accelerating Kidney Disease Science

  A center-led effort to provide expert rodent models and kidney physiology tools to researchers studying acute kidney injury, helping translate findings toward prevention and treatment.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11395319

• Predicting kidney injury after surgery using genes and health records

  A doctor-led project uses genetic information and your medical records to flag people who might develop acute kidney injury after surgery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11384726

• Illuminating human kidney injury with advanced tissue imaging

  This grant helps researchers map kidney injury in people by using a powerful imaging technique on kidney biopsy tissue to reveal cellular details that could guide better treatments.

  NIH research Yale University · New Haven, United States · NIH-11378497

• Biomarkers to identify kidney injury sub-types in sepsis patients

  This grant tests whether two distinct kidney injury sub-types in sepsis can be found early in emergency care and used to guide better treatment.

  NIH research University of Washington · Seattle, United States · NIH-11369266

• IMPROVE-AKI: Team coaching to prevent kidney injury after heart catheterization

  A large study tests a team-based coaching program to help hospitals use proven practices that prevent kidney injury after heart catheter procedures.

  NIH research Dartmouth College · Hanover, United States · NIH-11366819

• Cardiac Surgery Anesthesia Best Practices to Reduce Kidney Injury

  A research project at a major university aims to reduce kidney injury after heart surgery by improving anesthesia and intraoperative care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11353817

• How the body's early immune response affects sudden kidney injury

  This research looks at how early immune cells in the kidney affect sudden kidney damage and the healing that follows.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11353769

• How breathing machines can harm the kidneys

  Doctors will look at how ventilators change kidney filtering and salt handling in people who are critically ill to help prevent kidney damage.

  NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11349714

• Personalized AI to predict sudden kidney injury

  This project uses personalized machine learning on hospital records to predict which hospitalized patients are likely to develop acute kidney injury so clinicians can act sooner.

  NIH research University of Florida · Gainesville, United States · NIH-11345244

• How free heme damages kidney cell mitochondria and drives sudden and chronic kidney injury

  This project looks at whether excess heme causes mitochondrial damage and aging-like changes in kidney cells that contribute to sudden (acute) and long-term (chronic) kidney injury in people at risk.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11320747

• Sudden (acute) kidney injury in children with chronic kidney disease

  This project looks at what leads to sudden kidney injury in children who already have chronic kidney disease so doctors can better prevent and treat it.

  NIH research Yale University · New Haven, United States · NIH-11319873

• Using platelet mitochondria to help kidneys recover after sudden injury

  This project tests whether giving healthy mitochondria carried by platelets can help people with sudden (acute) kidney injury regain kidney function.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11317163

• Blocking a protein (NPM1) to prevent sudden kidney damage after low blood flow

  This project develops a peptide drug to block a protein called NPM1 and try to protect people at high risk for sudden kidney damage during heart surgery.

  NIH research Boston Medical Center · Boston, United States · NIH-11317156

• Real-time urine oxygen monitor to prevent kidney injury during surgery

  A new non-invasive urine oxygen monitor is being developed to identify risk of acute kidney injury in patients undergoing cardiac surgery or in the ICU so doctors can intervene early.

  NIH research Kscube, LLC · Park City, United States · NIH-11313673

• TIGIT's role in sudden kidney injury and healing

  This work looks at whether a protein called TIGIT makes sudden kidney damage worse and whether blocking it could help people with acute kidney injury or kidney side effects from cancer immunotherapy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11311301

• How cancer immunotherapy can trigger T cells to damage the kidneys

  This project looks for the specific immune T cells and targets that cause sudden kidney injury in people treated with cancer immunotherapy.

  NIH research Washington University · Saint Louis, United States · NIH-11309194

• Using AI to predict outcomes for people on continuous dialysis for acute kidney injury

  This project uses artificial intelligence to predict survival and whether kidneys will recover for ICU patients receiving continuous dialysis for acute kidney injury.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11309119

• Improving understanding of acute kidney injury in older veterans

  This study is looking at how genetics might affect the risk of serious kidney problems in older veterans, with the hope of finding better ways to treat and help those who develop acute kidney injury.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11291839

• Improving understanding of acute kidney injury in older veterans

  This study is looking at how genetics might affect the risk of older veterans developing a serious kidney problem called acute kidney injury, with the goal of finding better ways to treat it and help those who are affected.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11281231

• Improving understanding of acute kidney injury in older veterans

  This study is looking at how genetics and biology affect the risk of serious kidney problems in older veterans, with the hope of finding better ways to treat these issues and help patients feel better.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11280838

• Understanding acute kidney injury in older veterans

  This study is looking at how genetics might play a role in acute kidney injury (AKI) to help improve treatment options for older veterans, and it invites patients to share their health information to support this important research.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11266170

• A potential drug to protect kidneys after injury by boosting mitochondrial cleanup

  A new drug candidate that blocks USP30 could protect the kidneys after injury, potentially preventing progression to long‑term kidney disease for patients recovering from events like heart surgery.

  NIH research Vincere Biosciences, INC. · Cambridge, UNITED STATES · NIH-11256218

• How the kidney's support network helps it heal after sudden injury

  Researchers are looking at whether interactions between kidney cells and their surrounding support matrix help people recover after acute kidney injury.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11252882

• Which blood‑pressure drug during major surgery better protects the kidneys

  This compares two common medicines given for low blood pressure during major non‑cardiac surgery to find which one best prevents sudden kidney injury in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11176032

• Mapping Kidney Damage in Acute and Chronic Kidney Disease

  This project uses advanced imaging to create detailed maps of kidney tissue from patients with acute and chronic kidney disease to better understand these conditions.

  NIH research Yale University · New Haven, United States · NIH-11174488

• Investigating how a protein affects kidney injury and metabolism

  This study is looking at how a protein called CtBP2 affects kidney damage in people with acute kidney injury (AKI) and aims to find new ways to protect kidney function by understanding how energy changes in the body contribute to this condition.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11174187

• Investigating how immune responses during cancer treatment can lead to kidney injury

  This study is looking at how immunotherapy, a popular cancer treatment, can sometimes harm the kidneys, and it aims to find ways to prevent this damage so that patients can continue their cancer treatment safely.

  NIH research Washington University · Saint Louis, United States · NIH-11170211

• Understanding and improving treatment for acute kidney injury

  This study is bringing together doctors and researchers to share ideas and find better treatments for acute kidney injury, so that patients can have better outcomes and avoid long-term kidney issues.

  NIH research American Society of Nephrology, INC. · Washington, United States · NIH-11168417

• New Carbon Monoxide Medicines for Acute Kidney Injury

  This research explores new carbon monoxide-based medicines to help patients with acute kidney injury, a serious condition with limited treatment options.

  NIH research Georgia State University · Atlanta, United States · NIH-11164581

• Understanding Kidney Problems After Heart Surgery

  This research looks at specific blood markers to understand why some people develop kidney problems after heart surgery, hoping to find ways to prevent it.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11163318

• Improving anesthesia practices to prevent kidney injury after heart surgery

  This study is looking at how better anesthesia techniques during heart surgery can help protect your kidneys and reduce the chances of kidney problems afterward, so if you're having heart surgery, this research is all about making your recovery safer and healthier.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11163225

• Improving urine protein testing after kidney injury

  This study is looking at how to make it easier for doctors to test protein levels in urine after someone has had an acute kidney injury, so they can better manage kidney health and help patients get the care they need.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11143660

Related topics

Quick answers

How many Acute Kidney Injury clinical trials are recruiting right now?

121, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 38 countries. The most sites are in United States (35 trials), France (17 trials), China (13 trials), Canada (12 trials), Germany (9 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 14, Phase 4: 9, Phase 3: 3, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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