Assessing pulse pressure to estimate stroke volume in critically ill patients
Official title: Can Pulse Pressure Assessment at the Bedside Detect Low Values or Track Changes of Stroke Volume in Critically Ill Patients? The Multicenter, Cross-sectional, Observational, ANDROMEDA-PEGASUS Study
Run by Pontificia Universidad Catolica de Chile · NCT06737614 · Data updated 2026-11-12
This study is testing if measuring pulse pressure can help doctors better understand and manage blood flow in critically ill patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | Pontificia Universidad Catolica de Chile Academic / other |
| Locations | 3 sites (São Paulo and 2 other locations) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | October 30, 2025 |
| Study ends | January 30, 2026 |
| Registry record updated | May 29, 2025 |
| Trial ID | NCT06737614 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are critically ill patients aged 18 and older who are admitted to the ICU with a functioning arterial line.
✕Probably not a fit
Patients who are pregnant, require extracorporeal circulation, or have inadequate arterial line transduction may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the ability of pulse pressure to predict stroke volume in critically ill patients using bedside echocardiography. The researchers hypothesize that pulse pressure can effectively identify low stroke volume and monitor changes during various cardiovascular interventions. By measuring pulse pressure from an arterial line alongside left ventricular outflow tract velocity time integral, the study will gather comprehensive clinical, hemodynamic, and echocardiographic data. This approach seeks to improve the management of cardiovascular dysfunction in emergency and intensive care settings.
Why it matters
Potential benefit: If successful, this study could provide a simple and cost-effective method for monitoring stroke volume in critically ill patients, potentially improving patient outcomes.
How similar studies have gone: While the use of pulse pressure as a surrogate for stroke volume has been observed in experimental settings, this specific approach in critically ill patients is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years * Admitted to ICU * Functioning arterial line in place Exclusion Criteria: * Pregnancy * Inadequate arterial line transduction (see below) * Refusal of consent * Patient who requires extracorporeal circulation
Where it's running
-
Hospital Do Coracao
São Paulo, Brazil Recruiting -
Hospital Clinico UC Christus
Santiago, Chile Recruiting -
Fundacion Valle del Lili
Cali, Colombia Recruiting
Study contacts
- Principal investigator: Eduardo Kattan, MD, PhD — Assistant Professor
- Study coordinator: Eduardo Kattan, MD, PhD
- Email: e.kattan@gmail.com
- Phone: +56223543292
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.