Clinical trial Recruiting at 3 sites Observational Ages 18 and up

Assessing pulse pressure to estimate stroke volume in critically ill patients

Official title: Can Pulse Pressure Assessment at the Bedside Detect Low Values or Track Changes of Stroke Volume in Critically Ill Patients? The Multicenter, Cross-sectional, Observational, ANDROMEDA-PEGASUS Study

Run by Pontificia Universidad Catolica de Chile · NCT06737614 · Data updated 2026-11-12

This study is testing if measuring pulse pressure can help doctors better understand and manage blood flow in critically ill patients.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1500 (estimated)
SponsorPontificia Universidad Catolica de Chile
Academic / other
Locations3 sites (São Paulo and 2 other locations)
StatusRecruiting
StartedMay 1, 2025
Main results expectedOctober 30, 2025
Study endsJanuary 30, 2026
Registry record updatedMay 29, 2025
Trial IDNCT06737614 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are critically ill patients aged 18 and older who are admitted to the ICU with a functioning arterial line.

Probably not a fit

Patients who are pregnant, require extracorporeal circulation, or have inadequate arterial line transduction may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the ability of pulse pressure to predict stroke volume in critically ill patients using bedside echocardiography. The researchers hypothesize that pulse pressure can effectively identify low stroke volume and monitor changes during various cardiovascular interventions. By measuring pulse pressure from an arterial line alongside left ventricular outflow tract velocity time integral, the study will gather comprehensive clinical, hemodynamic, and echocardiographic data. This approach seeks to improve the management of cardiovascular dysfunction in emergency and intensive care settings.

Why it matters

Potential benefit: If successful, this study could provide a simple and cost-effective method for monitoring stroke volume in critically ill patients, potentially improving patient outcomes.

How similar studies have gone: While the use of pulse pressure as a surrogate for stroke volume has been observed in experimental settings, this specific approach in critically ill patients is novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years
* Admitted to ICU
* Functioning arterial line in place

Exclusion Criteria:

* Pregnancy
* Inadequate arterial line transduction (see below)
* Refusal of consent
* Patient who requires extracorporeal circulation

Where it's running

  • Hospital Do Coracao
    São Paulo, Brazil
    Recruiting
  • Hospital Clinico UC Christus
    Santiago, Chile
    Recruiting
  • Fundacion Valle del Lili
    Cali, Colombia
    Recruiting

Study contacts

  • Principal investigator: Eduardo Kattan, MD, PhD — Assistant Professor
  • Study coordinator: Eduardo Kattan, MD, PhD
  • Email: e.kattan@gmail.com
  • Phone: +56223543292

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.