Assessing pulse pressure to estimate stroke volume in critically ill patients
Can Pulse Pressure Assessment at the Bedside Detect Low Values or Track Changes of Stroke Volume in Critically Ill Patients? The Multicenter, Cross-sectional, Observational, ANDROMEDA-PEGASUS Study
This study is testing if measuring pulse pressure can help doctors better understand and manage blood flow in critically ill patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Pontificia Universidad Catolica de Chile Academic / other |
| Locations | 3 sites (São Paulo and 2 other locations) |
| Trial ID | NCT06737614 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the ability of pulse pressure to predict stroke volume in critically ill patients using bedside echocardiography. The researchers hypothesize that pulse pressure can effectively identify low stroke volume and monitor changes during various cardiovascular interventions. By measuring pulse pressure from an arterial line alongside left ventricular outflow tract velocity time integral, the study will gather comprehensive clinical, hemodynamic, and echocardiographic data. This approach seeks to improve the management of cardiovascular dysfunction in emergency and intensive care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients aged 18 and older who are admitted to the ICU with a functioning arterial line.
Not a fit: Patients who are pregnant, require extracorporeal circulation, or have inadequate arterial line transduction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a simple and cost-effective method for monitoring stroke volume in critically ill patients, potentially improving patient outcomes.
How similar studies have performed: While the use of pulse pressure as a surrogate for stroke volume has been observed in experimental settings, this specific approach in critically ill patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years * Admitted to ICU * Functioning arterial line in place Exclusion Criteria: * Pregnancy * Inadequate arterial line transduction (see below) * Refusal of consent * Patient who requires extracorporeal circulation
Where this trial is running
São Paulo and 2 other locations
- Hospital Do Coracao — São Paulo, Brazil (Recruiting)
- Hospital Clinico UC Christus — Santiago, Chile (Recruiting)
- Fundacion Valle del Lili — Cali, Colombia (Recruiting)
Study contacts
- Principal investigator: Eduardo Kattan, MD, PhD — Assistant Professor
- Study coordinator: Eduardo Kattan, MD, PhD
- Email: e.kattan@gmail.com
- Phone: +56223543292
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.