Understanding Energy Use to Predict Immune Problems and Long-Term Trouble After Burn Injury
Official title: Understanding Energy Utilization to Predict Immune Dysfunction and Chronic Critical Illness
Funded at Ut Southwestern Medical Center · NIH-11334968 · Data updated 2026-11-12
Aims to understand how energy use in the body relates to immune problems and lasting illness after severe injuries like burns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $424,615 |
| NIH project number | 1R35GM164256-01 |
| Project ID | NIH-11334968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have experienced severe burn injuries or major critical illness and are at risk of developing chronic critical illness.
✕Less likely to help
Patients who recover quickly from acute illness may not experience the long-term issues studied.
What this research studies
This project looks at why some ICU patients who survive the initial injury go on to develop chronic critical illness and disability. It combines bedside patient care with basic science to identify energy and immune system changes that accompany long recovery. Researchers will study how energy needs and immune responses interact during the transition from acute illness to chronic illness. The goal is to find markers and mechanisms that could guide better treatments in the future.
Why it matters
Potential benefit: If successful, findings could lead to earlier interventions that reduce disability and improve recovery for ICU survivors with burn injuries.
How similar studies have gone: Previous work shows that energy and immune dysfunction are linked to worse outcomes in critical illness, but precise mechanisms and interventions remain under investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Nomellini, Vanessa — Ut Southwestern Medical Center
- Study coordinator: Nomellini, Vanessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.