Personalized Care for Sepsis and Critical Illness
Official title: Precision Medicine in Sepsis with Critical Illness
Funded at Washington University · NIH-11126587 · Data updated 2026-11-12
This work aims to find different types of sepsis in patients to help doctors choose the best treatments for each person.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM142992-05 |
| Project ID | NIH-11126587 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for future clinical applications of this work would be patients experiencing sepsis or acute respiratory distress syndrome (ARDS) in critical care settings.
✕Less likely to help
Patients who do not have sepsis or ARDS would not directly benefit from this specific research.
What this research studies
Sepsis is a serious condition where the body's response to infection harms its own tissues and organs, often leading to death. Current treatments for sepsis haven't worked well for everyone because sepsis affects people differently. This project looks for specific patterns in patients' bodies, called 'phenotypes,' that show how their immune system is reacting. By understanding these patterns, doctors hope to match patients with the right treatments, moving towards more personalized care for sepsis and related critical illnesses like ARDS.
Why it matters
Potential benefit: If successful, this work could lead to new ways to classify sepsis patients and guide doctors in selecting more effective, tailored treatments, potentially improving survival rates.
How similar studies have gone: Previous analyses of ARDS clinical trials have successfully identified distinct patient groups that respond differently to therapies, suggesting a similar approach could work for sepsis.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Sinha, Pratik — Washington University
- Study coordinator: Sinha, Pratik
Related research
Other NIH-funded projects on the same topics.
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Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis
Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.
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Precision medicine in sepsis with critical illness
A patient-facing overview of a Stanford-led effort to tailor sepsis treatment by identifying subgroups of patients who may respond to specific therapies.
-
Understanding Chronic Critical Illness After Severe Injury or Infection
This work aims to better understand why some patients stay very sick for a long time after severe injuries or infections like sepsis.
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Understanding immune responses in patients with chronic critical illness after severe trauma or sepsis
This study is looking at how the immune system works in people who have survived serious injuries or infections and are dealing with ongoing health problems, like frequent infections and muscle weakness, to find better ways to help them feel better.
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Understanding how different biological responses affect sepsis treatment
This study is looking at different ways sepsis affects people based on their immune responses, so we can find better treatments that fit each person's needs and improve care for those dealing with this serious condition.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.