Indirect calorimetry-guided nutrition in critically ill adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial enrolls mechanically ventilated adults with an expected ICU stay over 72 hours to compare indirect calorimetry-guided nutrition against standard formula-based feeding. The intervention uses measured resting energy expenditure to set energy targets and gradually increases delivery per ESPEN guidelines. Primary outcome is quality of life at 3 months post-ICU, measured with EQ-5D-5L, with secondary goals including functional recovery, muscle preservation, infection rates, and rehospitalization. This approach aims to determine if personalized energy targets during critical illness lead to better long-term patient-centered outcomes. The study is led by HEIDEGGER CP with collaborators at Geneva University Hospital, GHOL Nyon, and Zürich University Hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All patients admitted to the ICU with the following criteria:

* ≥18 years old
* On Mechanical Ventilation
* Expected ICU length of stay \>72 hours

Exclusion Criteria:

* Refusal of the family or patient
* Patient transferred from another ICU
* Pregnant patient
* Patient is planned for a withdrawal of care or is actively dying
* Cognitive disorder before ICU
* Patient is in jail
* Patients already enrolled in the ongoing NutriPhyT trial

Where it's running

• Geneva University Hospital
  Geneva, Switzerland Recruiting
• Ghol
  Nyon, Switzerland Recruiting
• Zürich University Hospitals
  Zurich, Switzerland Recruiting

Study contacts

• Study coordinator: Claudia Paula Heidegger, Prof.
• Email: claudia.heidegger@hug.ch
• Phone: +41223727440

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.