Ciprofol versus propofol for sedating adult ICU patients on noninvasive respiratory support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective observational comparison of adults admitted to the ICU at Nanfang Hospital who received intravenous ciprofol or propofol for sedation while not invasively ventilated. Researchers will use electronic medical records from Jan 1, 2022 to Jul 30, 2024 to compare sedation depth (RASS), vital signs, respiratory events, hemodynamic instability, and need for escalation to endotracheal intubation. Patients must have received at least two hours of the index sedative and have continuous monitoring and complete sedation assessments. Safety endpoints will focus on respiratory depression, hypoxemia, hypotension, and sedation-related adverse events in the non-intubated ICU population.

Why it matters

Who can join: the full rules

Inclusion Criteria Age:

* Age ≥18 years
* Admitted to the intensive care unit (ICU) between January 1, 2022 and July 30, 2024
* Received intravenous sedation with either ciprofol or propofol during ICU stay
* Total duration of ciprofol or propofol administration ≥2 hours
* Sedation initiated while the patient was not receiving invasive mechanical ventilation
* Receiving non-invasive respiratory support or oxygen therapy at the time sedation was started, including noninvasive ventilation (NIV), high-flow nasal cannula (HFNC), nasal cannula, or face mask oxygen therapy
* Availability of complete electronic medical records including sedation assessment using the Richmond Agitation-Sedation Scale (RASS)
* Availability of continuous vital sign monitoring records including respiratory rate, oxygen saturation, blood pressure, and heart rate

Exclusion Criteria:

* Age \<18 years
* Pregnancy or breastfeeding
* Use of other primary sedative agents during the observation period, including midazolam or dexmedetomidine
* Total exposure time to ciprofol or propofol \<2 hours
* Known allergy or hypersensitivity to ciprofol, propofol, or their formulation components
* Initiation of invasive mechanical ventilation before sedation
* Missing key clinical data required for outcome evaluation, including sedation score, vital signs, or drug administration records
* Participation in other interventional clinical trials that may interfere with outcome assessment
* Severe visual or hearing impairment preventing accurate sedation assessment
* Coma or conditions that prevent reliable evaluation using the Richmond Agitation-Sedation Scale (RASS)
* Any condition that the investigators consider inappropriate for inclusion in the study

Where it's running

• Nanfang Hospital, Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: zhenhua zeng, doctor
• Email: hzengzhu@163.com
• Phone: +86 18529269527

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.