Condition

Postoperative Pain clinical trials and research

• 179Clinical trials
• 17NIH research projects
• 9New in 30 days
• 27Countries

Newest Postoperative Pain clinical trials

All recruiting trials (newest 150 of 179)

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

• Alpha-Band Binaural Beats During Third Molar Surgery

  This study tests whether listening to 10 Hz alpha-band binaural beats embedded in rain sounds can reduce preoperative anxiety and improve recovery for adults undergoing impacted third molar extraction.

  Recruiting Recep Tayyip Erdogan University · Rize · NCT07881640

• Two Ways to Help Pain After Breast Surgery: Education-Based Analgesia vs Standard Care

  This trial tests whether teaching patients about pain management and using a multimodal pain plan improves pain control and recovery after breast surgery compared with standard care.

  Recruiting University General Hospital of Heraklion · Heraklion, Crete · NCT07880223

• Dexmedetomidine added to a nerve block for middle ear surgery

  In adults having elective middle ear surgery, this trial tests whether adding dexmedetomidine to bupivacaine for a greater auricular nerve block can extend pain relief after surgery.

  Recruiting Phase 2 Minia University · Minya · NCT07878533

• MTP block vs ESP block for pain control after VATS

  This trial tests whether the MTP block provides better pain relief than the ESP block after video-assisted thoracoscopic surgery in adults.

  Recruiting Udayana University · Denpasar, Bali · NCT07868484

• Pain control and recovery after thoracic surgery with the SPSIP block

  This study tests whether adding the SPSIP block helps adults recover better after thoracic surgery.

  Recruiting Izmir Katip Celebi University · Izmir, İzmir · NCT07850388

• External validation of an early predictor for adverse postoperative pain trajectories after orthopedic surgery

  This study tests a pre-made model to see if it can predict which adults will have troublesome pain after elective orthopedic surgery.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing · NCT07846878

• Epidural vs. opioid-sparing pain control after complex ventral hernia repair

  This trial tests whether an epidural for pain relief after transversus abdominis release hernia repair works better than a non‑opioid, abdominal wall numbing injection approach.

  Recruiting Phase 4 Northwestern University · Chicago, Illinois · NCT07840183

• Breakthrough Pain After Brachial Plexus Block in People With Type 2 Diabetes

  This study tests how often rebound pain happens after a nerve block in adults with type 2 diabetes compared with those without diabetes.

  Recruiting Second Hospital of Shanxi Medical University · Taiyuan · NCT07833930

• Postoperative pain relief after breast surgery using regional blocks

  This observational study will see how well two regional nerve blocks plus routine care reduce pain and opioid use in adults after elective breast surgery at one center.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa · NCT07830446

• Transcutaneous electrical stimulation at acupuncture points during abdominal surgery

  This study tests whether applying light electrical stimulation to specific acupuncture points around abdominal surgery can influence pain and vital signs in adults after surgery.

  Recruiting Beijing Chao Yang Hospital · Beijing · NCT07819630

• Subcostal TAP Block and EEG Changes During Laparoscopic Gallbladder Surgery

  This observational study tests whether adding a subcostal TAP block to standard IV opioid therapy affects intraoperative brain activity measures and pain needs in adults undergoing laparoscopic cholecystectomy.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul · NCT07818954

• Opioid-Free Anesthesia in FESS with ERAS

  This study tries a opioid-free anesthesia approach during functional endoscopic sinus surgery to see if pain, nausea, and recovery are improved for adults undergoing this procedure.

  Recruiting Ankara City Hospital Bilkent · Ankara, ÇANKAYA · NCT07812389

• Impact of a 1-file rotary system on debris extrusion during root canal treatment

  This study tests whether using a single-file AF One system during root canal shaping reduces postoperative discomfort in teeth with irreversible pulpitis and mature roots.

  Recruiting Minia University · Minya, Minya Governorate · NCT07808684

• Combined leg nerve blocks for kids with cerebral palsy after surgery

  This study tests whether adding two nerve blocks to standard anesthesia helps control pain in children with cerebral palsy after lower limb surgery.

  Recruiting Diskapi Yildirim Beyazit Education and Research Hospital · Ankara · NCT07801365

• Postoperative nausea, vomiting and pain after bariatric surgery in Sweden

  This study looks at how often people have nausea, vomiting, and pain after bariatric surgery in Sweden and whether anesthesia type or regional blocks affect those outcomes.

  Recruiting at 2 sites Umeå University · Sundsvall and 1 other locations · NCT07797374

• Enhanced Recovery Adherence and Recovery Quality After Cesarean Delivery

  This study tests whether following enhanced recovery after cesarean delivery protocols is linked with better recovery quality in women having a planned cesarean with spinal anesthesia.

  Recruiting Bursa City Hospital · Bursa, Nilüfer · NCT07790471

• Acupressure for Postoperative Pain After Laparoscopic TEP Hernia Repair

  This trial tests whether true acupressure, given after surgery, reduces pain more than sham acupressure or standard care for adults undergoing laparoscopic TEP inguinal hernia repair.

  Recruiting Medipol University · Istanbul, Istanbul · NCT07787871

• QL Block vs EO Plane Block for Pain After Open Kidney Removal

  In adults undergoing open nephrectomy, researchers will compare two ultrasound-guided nerve blocks (transmuscular quadratus lumborum vs external oblique plane) to see which provides better pain relief and less need for intravenous morphine after surgery.

  Recruiting at 2 sites Cairo University · Cairo and 1 other locations · NCT07787221

• Intrathecal Morphine or Dexmedetomidine for Pain After Spine Fixation

  This study tests whether delivering pain medicine into the spinal fluid with morphine or dexmedetomidine can better relieve pain after lumbar spine fixation surgery compared with placebo.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07777627

• Recto-Intercostal and External Oblique Intercostal Blocks for Pain after Laparoscopic Gallbladder Removal

  This trial tests whether adding a recto-intercostal fascial plane block to an existing external oblique intercostal plane block provides better pain relief after laparoscopic cholecystectomy in adults.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07777172

• Aromatherapy for Preoperative Anxiety, Postoperative Pain, and Patient Experience

  This study tests whether aromatherapy helps reduce preoperative anxiety and postoperative pain and improves the overall patient experience for adults undergoing surgery.

  Recruiting Kaiser Permanente · Stockton, California · NCT07771205

• Deep Subgluteal Block vs PENG + LFCN Block for Hip Arthroplasty Pain

  This randomized study compares two ultrasound-guided nerve blocks to see which provides better pain control after hip replacement.

  Recruiting Medipol University · Istanbul, Bagcilar · NCT07770932

• Comparison of two ultrasound-guided blocks for pain after modified radical mastectomy

  This trial tests whether the serratus posterior superior intercostal plane block (SPSIPB) provides better postoperative pain relief than the serratus anterior plane block (SAPB) for women undergoing modified radical mastectomy.

  Recruiting Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Istanbul, Uskudar · NCT07737132

• Transdermal buprenorphine patch added to multimodal pain relief after VATS

  This study tests whether adding a 5 mcg/hour buprenorphine patch to standard pain relief after unilateral VATS reduces pain in adults.

  Recruiting Clínica Dávila · Santiago, Santiago Metropolitan · NCT07733128

• ESPB vs SPSIPB for better recovery after VATS

  This study tests whether an erector spinae plane block or a serratus posterior superior intercostal plane block improves recovery after video-assisted thoracoscopic surgery.

  Recruiting at 2 sites Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır, Outside of the US and 1 other locations · NCT07729488

• Modified external oblique intercostal plane block vs erector spinae plane block for open nephrectomy

  This trial tests whether the EOIPB or ESPB provides better pain relief after open nephrectomy in adults.

  Recruiting Namik Kemal University · Tekirdağ, Tekirdağ · NCT07726550

• Nephrostomy Tract Infiltration to Ease Pain After Percutaneous Nephrolithotomy

  This trial tests whether injecting local anesthetic into the nephrostomy tract after PCNL helps reduce postoperative pain for adults undergoing the procedure.

  Recruiting Hitit University · Çorum, Çorum · NCT07721571

• Combining a nerve block with intrathecal morphine for better pain relief after major abdominal surgery

  This study tests whether adding intrathecal morphine to an erector spinae plane block helps adults have less pain and use fewer opioids in the first two days after a midline laparotomy.

  Recruiting Sohag University · Sohag · NCT07720739

• Prevention of chronic postsurgical pain in people who regularly use opioids

  This trial tests whether adding a telemedicine post-surgery consult between days 15 and 28 helps reduce long-term pain and opioid use in adults on chronic opioids undergoing elective surgery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07717151

• Quadroiliac Plane Block for Pain Relief After Kidney Transplant

  This trial tests whether an ultrasound-guided unilateral quadroiliac plane block can reduce pain and opioid use after kidney transplant compared with standard surgical wound infiltration.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Istanbul, Istanbul · NCT07716566

• Lateral Quadratus Lumborum Block vs Intrathecal Morphine for Cesarean Section analgesia

  This study tests whether a lateral quadratus lumborum block can provide pain relief after cesarean delivery as effectively as intrathecal morphine.

  Recruiting Ondokuz Mayıs University · Samsun · NCT07712783

• How different pain control methods affect early mobilization after major surgery in older ICU patients

  In this real-world study, researchers will observe how pain-relief methods used after major surgery in adults 65 and older in the ICU relate to how quickly they get out of bed and start moving.

  Recruiting Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Istanbul, Istanbul · NCT07709975

• HL-1186 Tablet for postoperative pain after abdominal surgery

  This trial tests HL-1186 tablets to see if they reduce pain after abdominal surgery compared with placebo and an oxycodone-acetaminophen option.

  Recruiting Phase 2/3 Shanghai Huilun Pharmaceutical Co., Ltd. · Chengdu, Sichuan · NCT07709598

• WeChat-supported neck exercises after thyroidectomy

  A telehealth program using a WeChat mini program tests if guided neck exercises after thyroid surgery help early recovery and quality of life.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT07707401

• QLESP Block to Ease Pain After Robot-Assisted Kidney Surgery

  Doctors are testing a ultrasound-guided nerve block called QLESP to see if it lowers pain and reduces strong pain medicines after robotic partial nephrectomy in adults.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT07704970

• HL-1186 Tablet for postoperative pain after orthopedic surgery

  A mid-to-late phase trial tests HL-1186 tablets against placebo and standard opioid therapy to see if they can help manage pain after orthopedic surgery for adults 18–75.

  Recruiting Phase 2/3 Shanghai Huilun Pharmaceutical Co., Ltd. · Changsha, Hunan · NCT07699601

• Transversalis fascia plane block vs low-dose intrathecal morphine for open inguinal hernia repair

  This trial tests whether a ultrasound-guided transversalis fascia plane block can provide comparable pain relief to low-dose intrathecal morphine after open inguinal hernia repair.

  Recruiting Hitit University · Çorum · NCT07695935

• Serratus vs Erector Spinae Block for Pain After Unilateral Breast Surgery

  This trial tests whether serratus posterior superior intercostal plane block or erector spinae plane block reduces chronic pain 3 months after unilateral breast surgery in adult women.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07674836

• Interscalene Block vs SPSIP Block for Shoulder Arthroscopy analgesia

  This study tests whether the SPSIP block can provide comparable pain relief to the standard interscalene block after arthroscopic shoulder surgery.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Nilüfer · NCT07668648

• RISS vs SPSIP Block in Mastectomy

  This study tests whether the rhomboid intercostal-subserratus plane (RISS) block provides better pain control after modified radical mastectomy than the serratus posterior superior intercostal plane (SPSIP) block.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Nilüfer · NCT07659990

• SPSIP vs RISS Block for pain relief after volume-preserving VATS

  This randomized trial tests whether the SPSIP block can better control chest pain after VATS than the RISS block in adults undergoing lung-preserving surgery.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Nilüfer · NCT07655336

• ESP vs RISS blocks for pain after gallbladder removal

  This study tests whether bilateral erector spinae plane (ESP) blocks or bilateral rhomboid intercostal-subserratus plane (RISS) blocks provide better pain relief after laparoscopic cholecystectomy.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Nilüfer · NCT07655323

• Erector Spinae Plane Block with Low-Flow Anaesthesia in Laparoscopic Cholecystectomy

  This trial tests whether a nerve block done before surgery plus very low-flow anesthesia reduces pain and opioid use after gallbladder removal.

  Recruiting Taksim Egitim ve Arastirma Hastanesi · Istanbul · NCT07653490

• Liposomal Bupivacaine TAP Block Plus Pain Control to Help Gut Recovery After Major Abdominal Surgery

  This trial tests whether adding liposomal bupivacaine TAP block to a sufentanil or oxycodone-based pain plan helps people recover gut function after major abdominal surgery.

  Recruiting Tianjin First Central Hospital · Tianjin, Tianjin Municipality · NCT07651722

• Bupivacaine irrigation for pain after gallbladder surgery

  This trial tests whether irrigating the abdominal cavity with bupivacaine reduces pain after laparoscopic cholecystectomy compared with saline irrigation in adults 18–60.

  Recruiting Phase 4 Wah Medical college , POF hospital · Wāh, Punjab Province · NCT07650760

• Dexketoprofen given by IV to see if it reduces rebound pain after shoulder block

  This study tests whether giving an IV dose of dexketoprofen after shoulder surgery can lessen or prevent rebound pain when a nerve block wears off.

  Recruiting Eskisehir Osmangazi University · Eskişehir, Odunpazarı · NCT07642674

• ESP vs EXORA blocks after laparoscopic nephrectomy

  This observational study compares two pain-control blocks (ESP and EXORA) used after laparoscopic kidney removal to see which provides better pain relief and recovery.

  Recruiting Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Istanbul, Istanbul · NCT07640282

• Transauricular Vagus Nerve Stimulation at Different Frequencies for Postoperative Pain

  Researchers will test whether different tVNS frequencies can lessen pain and reduce opioid use after abdominal or urologic surgery.

  Recruiting Federal University of Bahia · Salvador, Estado de Bahia · NCT07633444

• Cryotherapy to Cut Opioid Use After Knee Replacement

  This trial tests whether compressive cryotherapy with a Game Ready device can lower opioid use and improve recovery after total knee replacement in adults 60–80.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT07630337

• Sacral ESP Block vs Caudal Block for Pain Control in Pediatric Hypospadias Repair

  In kids undergoing hypospadias surgery, this study tests whether a sacral erector spinae plane (ESP) block provides pain relief after surgery as well as or better than the traditional caudal block.

  Recruiting TC Erciyes University · Kayseri · NCT07619651

• Comparison of meta-PENG vs suprainguinal fascia iliaca block for hip fracture pain

  This study tests whether two ultrasound-guided nerve blocks help with pain control for adults having hip fracture surgery under spinal anesthesia.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul, Istanbul · NCT07612761

• Does adding a TAP block with low-dose ropivacaine help after cesarean birth?

  This study tests whether adding a TAP block to standard pain relief after cesarean delivery reduces pain and opioid use in the first 24 hours for women.

  Recruiting Tîrgu Mureș Emergency Clinical County Hospital, Romania · Târgu Mureş, Mureș County · NCT07604376

• Serratus Posterior Superior Intercostal Plane Block to Ease Pain After Minimally Invasive Valve Surgery

  This study tests whether the SPSIP block with local anesthetic can lower pain and reduce opioid use after minimally invasive heart valve surgery.

  Recruiting Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır, Outside of the US · NCT07588230

• Ultrasound-Guided Rectus Sheath Block vs Local Infiltration for Pain After Laparoscopic Gallbladder Removal

  This trial tests whether a rectus sheath block or direct local anesthetic infiltration provides better pain control after laparoscopic cholecystectomy.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul · NCT07582029

• Liposomal Bupivacaine vs Ropivacaine for TAP Block in Laparoscopic Gallbladder Surgery

  In people having gallbladder removal with laparoscopy, this study tests whether liposomal bupivacaine for a TAP block reduces pain compared with standard ropivacaine.

  Recruiting Tianjin First Central Hospital · Tianjin, Tianjin Municipality · NCT07577934

• Conox-guided anesthesia for children having adenotonsillectomy

  This trial will test whether using Conox (qCON/qNOX) monitoring during anesthesia helps children aged 3-12 having adenotonsillectomy use less opioid and recover more smoothly after surgery.

  Recruiting Kayseri City Hospital · Kayseri · NCT07577154

• PARO robotic seal to reduce agitation after visceral surgery

  This trial tests whether interacting with PARO, a social robotic seal, reduces postoperative agitation in adults having elective visceral surgery.

  Recruiting Hannover Medical School · Hanover, Lower Saxony · NCT07568093

• Preventive Analgesia With Anrikefon in Laparoscopic Gallbladder Surgery

  This study tests whether giving Anrikefon before or during laparoscopic cholecystectomy can reduce early postoperative pain.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT07566663

• SPSIP vs ESP Block for Pain After Mastectomy

  This study tests whether the serratus posterior superior intercostal plane (SPSIP) block or the erector spinae plane (ESP) block provides a more comfortable, easier-to-place pain relief option after mastectomy.

  Recruiting Sakarya University · Sakarya · NCT07561853

• ACB plus IPACK versus ACB plus BiFeS blocks for pain control after total knee replacement

  This trial will test whether adding an IPACK or a BiFeS block to an adductor canal block gives better pain relief for adults (18–80) having primary total knee replacement under spinal anesthesia.

  Recruiting Hitit University · Çorum, Centre · NCT07561333

• Comparing periarticular vasoconstrictor infiltration and erector spinae plane block to reduce bleeding and pain in lumbar fusion

  This trial will try periarticular vasoconstrictor infiltration versus erector spinae plane block to see if one reduces blood loss and postoperative pain in adults having lumbar fusion surgery.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona, Barcelona and 1 other locations · NCT07550114

• Pain medication needs in the first hours after elective surgery in the PACU

  This study will see which patient, surgery, and anesthesia factors are linked to how much pain medicine adults need immediately after elective surgery while in the post-anesthesia care unit (PACU).

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Ankara, Yenimahalle · NCT07547618

• Managing pain after free gingival graft harvesting with Ora-Aid versus an acrylic palatal stent

  This trial will test whether an Ora-Aid hydrogel dressing or an acrylic palatal stent better reduces pain for adults after free gingival graft donor-site harvesting.

  Recruiting Cairo University · Cairo · NCT07523802

• Pain relief after abdominal surgery with SYH9089: early safety and dosing in adults

  A small early study will test if SYH9089 helps with pain after abdominal surgery compared to placebo, in adults 18–75, while also checking safety and how the drug stays in the body.

  Recruiting Phase 1 CSPC Ouyi Pharmaceutical Co., Ltd. · Changsha, Hunan · NCT07519109

• Comparing two ultrasound-guided chest wall nerve blocks for pain after mastectomy

  This study will see if one of two ultrasound-guided chest wall nerve blocks gives better pain relief and less opioid use for women having an elective mastectomy.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07510269

• External oblique intercostal block versus transversus abdominis plane plus rectus sheath block for pain after laparoscopic radical gastrectomy

  This test sees if the external oblique intercostal block gives pain relief as good as the transversus abdominis plane plus rectus sheath block for adults having laparoscopic radical gastrectomy.

  Recruiting General Hospital of Ningxia Medical University · Yinchuan · NCT07496086

• Effectiveness of M-TAPA nerve block for pain relief after laparoscopic hysterectomy

  This study tests whether the M-TAPA nerve block before surgery can reduce opioid use and pain after laparoscopic hysterectomy compared with standard pain care.

  Recruiting Istinye University · Istanbul · NCT07483190

• Intranasal dexmedetomidine‑esketamine for pain relief after adenoid and tonsil surgery in children

  This trial will test whether giving children aged 3–7 a combined dexmedetomidine and esketamine nasal dose reduces pain after adenoid and tonsil surgery.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07479602

• Comparing a single erector spinae block to parasternal plus serratus blocks for pain after sternotomy

  We will see if a single erector spinae nerve block or a combination of superficial parasternal and serratus anterior blocks better controls pain and reduces opioid use in adults having elective open‑chest (sternotomy) heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07472296

• Ultrasound-Guided Rhomboid-Intercostal Block vs Thoracic Paravertebral Block for Pain Control After VATS

  This study tests whether the rhomboid-intercostal block (RIB) or the thoracic paravertebral block (PVB) provides better pain relief after a 3-port VATS chest surgery in adults.

  Recruiting Blue Cross of Thessaloniki · Thessaloniki · NCT07465887

• Breathwork for older adults after knee replacement

  This study tests whether a quick, at-home breathwork activity can help adults 65 and older recover better after knee replacement surgery.

  Recruiting University of Arizona · Tucson, Arizona · NCT07464860

• FRONT block for recovery after total hip replacement

  This trial will see if adding an ultrasound-guided FRONT block to standard pain care helps adults having elective total hip replacement recover better after surgery.

  Recruiting Konya Meram State Hospital · Konya · NCT07458360

• Monitoring postoperative pain after lumbar spine surgery using a heart-rate based pain index

  This study tests whether an ultrasound-guided erector spinae plane block or intravenous multimodal pain medicines give better pain control for adults having elective lumbar spine surgery, using pain scores and the Analgesia Nociception Index.

  Recruiting Akdeniz University Hospital · Antalya, Antalya · NCT07455565

• Combined transversus thoracic + serratus anterior plane blocks versus erector spinae plane block for pain after sternotomy

  This trial will try whether combining transversus thoracic and serratus anterior plane nerve blocks controls pain after median sternotomy better than an erector spinae plane block in adults having elective heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07452627

• DIPB vs SIFIB for pain control after total hip replacement

  This will test whether the Deep Iliacus Plane Block (DIPB) or the Suprainguinal Fascia Iliaca Block (SIFIB) gives better pain relief and less leg weakness for adults having elective total hip replacement.

  Recruiting Sivas Numune Hospital · Sivas, Sivas and 1 other locations · NCT07452120

• Breathing exercises to help after breast surgery

  This trial tests whether practicing pranayama or pursed-lip breathing after breast surgery can reduce pain and anxiety and stabilize vital signs compared with routine care.

  Recruiting Ondokuz Mayıs University · Istanbul, Istanbul · NCT07449273

• Bilateral rhomboid intercostal block to reduce pain after breast implant surgery

  This trial will test whether adding an ultrasound-guided bilateral rhomboid intercostal block to general anesthesia reduces pain and tramadol use after elective bilateral breast implant surgery in adults aged 18–65.

  Recruiting Aydin Adnan Menderes University · Aydin, Efeler · NCT07448246

• SPSIP versus ESPB nerve blocks for pain control after modified radical mastectomy

  This trial tests whether the newer SPSIP nerve block reduces pain and opioid (morphine) use more than the erector spinae plane block after modified radical mastectomy.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07446868

• Sacral ESPB versus PENG nerve block for pain after hip hemiarthroplasty

  We will see if a sacral erector spinae plane (S-ESPB) block or a pericapsular nerve group (PENG) block gives better pain relief for adults 50–90 having hip hemiarthroplasty for a femoral neck fracture.

  Recruiting Fayoum University Hospital · El Fayoum Qesm, Faiyum Governorate · NCT07442721

• Scalp nerve blocks plus dexmedetomidine to reduce opioids after brain tumor surgery

  This trial tests whether scalp nerve blocks and/or dexmedetomidine can reduce opioid needs and help prevent delirium after supratentorial brain tumor surgery.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07441421

• Best timing for subcostal TAP plus rectus sheath block to reduce pain after laparoscopic gallbladder removal

  This trial will test whether giving ultrasound-guided subcostal transversus abdominis plane (TAP) blocks combined with rectus sheath blocks before the incision or after surgery reduces pain for adults having elective laparoscopic gallbladder removal.

  Recruiting Eulji University Hospital · Seoul · NCT07440940

• Paracervical block for pain control after vNOTES uterosacral ligament suspension

  This will test whether a paracervical injection of bupivacaine reduces early postoperative pain in women having vNOTES uterosacral ligament suspension for pelvic organ prolapse.

  Recruiting Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Istanbul, Istanbul · NCT07440576

• Bupivacaine to reduce pain after laparoscopic hysterectomy

  This trial will test whether injecting 0.5% bupivacaine around the trocar sites and into the vaginal cuff at the end of a laparoscopic hysterectomy reduces early postoperative pain for women having the operation for benign conditions.

  Recruiting Gaziosmanpasa Research and Education Hospital · Istanbul, Gaziosmanpaşa · NCT07435909

• Intraoperative cryoanalgesia versus thoracic epidural block for pain control after minimally invasive pectus excavatum repair

  This trial will try intraoperative cryoanalgesia versus a thoracic epidural block to see which controls pain better after minimally invasive pectus excavatum repair in patients aged 13 and older.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07431632

• Comparing three shoulder nerve blocks for pain relief and breathing effects

  This study tests three different nerve blocks to see which best controls pain while preserving breathing after arthroscopic shoulder surgery.

  Recruiting Atatürk Chest Diseases and Chest Surgery Training and Research Hospital · Yenimahalle, Ankara · NCT07429669

• Comparing 4 mg versus 8 mg submucosal dexamethasone for pain after single-tooth dental implant surgery

  This will see if a 4 mg or 8 mg dexamethasone injection under the gum reduces pain after single-tooth dental implant surgery compared with a saline injection.

  Recruiting Phase 3 Oman Ministry of Health · Muscat · NCT07413055

• Serratus posterior superior intercostal plane block for pain control after off-pump minimally invasive CABG

  This trial will test whether an ultrasound-guided serratus posterior superior intercostal plane block with bupivacaine reduces postoperative pain in adults having elective off-pump minimally invasive coronary artery bypass grafting.

  Recruiting Kartal Kosuyolu High Speciality Training and Research Hospital · Istanbul · NCT07412522

• Bupivacaine with Epinephrine Sprayed Under the Diaphragm During Laparoscopy

  This study tests whether spraying bupivacaine with epinephrine under the diaphragm during laparoscopic gynecologic surgery reduces postoperative shoulder pain.

  Recruiting Phase 4 Cedars-Sinai Medical Center · Los Angeles, California · NCT07400146

• Botulinum toxin A injection before hemorrhoid surgery to reduce postoperative pain

  This study will see if injecting botulinum toxin A into the internal anal sphincter a week before hemorrhoidectomy reduces post-operative pain for adults with grade III–IV hemorrhoids.

  Recruiting Phase 2 Lomonosov Moscow State University Medical Research and Educational Center · Moscow, Moscow · NCT07399860

• External oblique intercostal block versus erector spinae plane block for pain after laparoscopic radical gastrectomy

  This trial will see if the external oblique intercostal block relieves pain as well as the erector spinae plane block for adults having laparoscopic radical gastrectomy.

  Recruiting General Hospital of Ningxia Medical University · Yinchuan, Ningxia · NCT07396545

• What affects pain after taking gum grafts from the palate?

  This project will see if patient, psychological, and clinical factors predict how much pain adults experience after having gum grafts taken from the palate.

  Recruiting Universitat Internacional de Catalunya · Barcelona, Sant Cugat Del Valles · NCT07377370

• Ultrasound-guided Quadro-Iliac Plane Block for pain after lumbar instrumentation

  This trial will try an ultrasound-guided Quadro-Iliac Plane Block to reduce postoperative pain in adults having elective lumbar instrumentation surgery.

  Recruiting Bursa City Hospital · Bursa · NCT07370428

• Finding the best single IV dose of tegileridine for pain after orthopedic surgery

  This test tries single IV doses of tegileridine in adults 18–75 having orthopedic surgery to see which dose gives good pain relief after surgery.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hanzhong, Zhejiang · NCT07353996

• Melatonin versus pregabalin for pain and anxiety after spine surgery

  This trial will test whether taking melatonin or pregabalin around the time of elective spine surgery reduces postoperative pain and anxiety in adults aged 21–60.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07344467

• Using pupillometry to measure acute pain in children and teens

  This project will test whether a non-invasive pupillometry device (AlgometRx Nociometer) can provide an objective measure of acute pain in children and adolescents ages 6 to 21 who are having elective surgery or undergoing bone marrow transplantation.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07336264

• Retrolaminar nerve block for lumbar surgery pain

  This trial will test whether adding an ultrasound-guided retrolaminar nerve block to standard multimodal pain management reduces opioid use after elective lumbar spine surgery.

  Recruiting Universidad de los Andes, Chile · Santiago, Santiago Metropolitan · NCT07334288

• External Oblique Intercostal Plane Block to Ease Pain After Major Upper Abdominal Surgery

  This study tests whether adding a bilateral External Oblique Intercostal Plane Block helps reduce pain and opioid use after major upper abdominal laparoscopic surgery.

  Recruiting Fudan University · Shanghai · NCT07331441

• Pranayama breathing after cesarean to ease pain

  This project tests whether pranayama breathing exercises can reduce postoperative pain and improve comfort for women after a cesarean delivery.

  Recruiting KTO Karatay University · Konya, Konya · NCT07329309

• Preoperative deep parasternal intercostal plane block to reduce opioid use during median sternotomy

  This will test whether a bilateral ultrasound-guided deep parasternal intercostal plane (DPIP) block given before surgery can reduce opioid use during and after elective median sternotomy in adults.

  Recruiting Gaziantep City Hospital · Gaziantep, Sahinbey · NCT07315308

• Keeping a pain diary after laparoscopic gallbladder removal

  This project will see if asking adults having elective laparoscopic gallbladder removal to keep a short pain diary helps track their early postoperative pain better than routine checks.

  Recruiting Muğla Sıtkı Koçman University · Muğla, Menteşe · NCT07308730

• TENS to reduce anxiety, pain, and improve satisfaction after laparoscopic gallbladder removal

  This trial will try TENS (mild electrical stimulation through the skin) in adults having elective laparoscopic gallbladder removal to see if it lowers anxiety, reduces postoperative pain, and improves satisfaction.

  Recruiting Nigde Omer Halisdemir University · Niğde, Adana · NCT07307703

• Hydrogen water oral care after free flap reconstruction for oral cancer

  A randomized trial tests whether hydrogen water oral care helps reduce inflammation and pain and improve oral bacteria after surgery for oral cancer.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT07306546

• Intraperitoneal spray plus IV lidocaine to reduce pain after laparoscopic myomectomy

  This will test whether using a lidocaine spray inside the abdomen plus IV lidocaine reduces pain after laparoscopic myomectomy in adults.

  Recruiting General Hospital of Ningxia Medical University · Yinchuan, Ningxia · NCT07268495

• Visually guided TAP block during laparoscopic TAPP inguinal hernia repair

  This will test whether giving a TAP nerve block under direct laparoscopic vision during elective TAPP inguinal hernia repair reduces postoperative pain and speeds recovery in adults.

  Recruiting University of Warmia and Mazury in Olsztyn · Olsztyn, Warmisko-mazurskie · NCT07264699

• Aescin (Reparil) versus Ibuprofen for pain, swelling, and limited mouth opening after impacted lower wisdom tooth removal

  We will test whether Reparil (aescin) works as well as ibuprofen to reduce pain, swelling, and jaw stiffness after impacted lower wisdom tooth removal in adults aged 18-40.

  Recruiting Oman Medical Speciality Board · Muscat, Al Khoud · NCT07244029

• Nerve block versus IV pain control after laparoscopic gallbladder removal

  This trial will test whether two ultrasound-guided nerve blocks (paravertebral and external oblique intercostal) cut pain and tramadol use compared with IV patient-controlled tramadol in adults having elective laparoscopic gallbladder removal.

  Recruiting Cukurova University · Adana · NCT07241949

• Erector spinae plane blocks to reduce pain after cervical or lumbar spinal fusion

  This trial tests whether an ESP block with bupivacaine (with or without liposomal bupivacaine) can lower pain and opioid use after cervical or lumbar posterior spinal fusion in adults.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT07228039

• Quadro Iliac Plane Block for Pain Control After Kidney Stone Surgery

  This study tests whether a regional block called QİPB can reduce pain after percutaneous nephrolithotomy in adults.

  Recruiting Cumhuriyet University · Sivas, Sivas · NCT07203859

• RADA16 gel to help kids recover after tonsillectomy

  This study tests whether applying RADA16 gel during pediatric tonsillectomy improves recovery compared with standard care.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · Livingston, New Jersey and 1 other locations · NCT07188779

• Fentanyl versus remifentanil during laparoscopic gallbladder removal: effects on bowel recovery and pain

  This compares fentanyl and remifentanil given during elective laparoscopic gallbladder removal to see which leads to faster bowel recovery and better pain control in adults 18–65.

  Recruiting Konya City Hospital · Karatay, Konya · NCT07182097

• Tea tree oil versus chlorhexidine mouthwash after impacted lower wisdom tooth removal

  This tests whether tea tree oil mouthwash can reduce swelling, pain, limited mouth opening, and help gum healing as well as standard chlorhexidine in adults after extraction of impacted lower wisdom teeth.

  Recruiting Harran University · Sanliurfa · NCT07180498

• Lignocaine versus GTN ointment for pain after hemorrhoidectomy

  This test compares lignocaine ointment and 0.2% glyceryl trinitrate (GTN) ointment to see which provides better pain relief for adults after hemorrhoidectomy.

  Recruiting King Edward Medical University · Lahore, Punjab Province · NCT07159334

• Regional anesthesia for knee replacement: effects on early joint motion and patient satisfaction

  We will test whether three different regional anesthesia approaches — an epidural catheter, an adductor canal catheter, or multimodal IV pain control — help adults having elective knee replacement move their knee better and feel more satisfied after surgery.

  Recruiting Konya City Hospital · Konya, Meram · NCT07124494

• Lidocaine plus dexmedetomidine during laparoscopic bariatric surgery to reduce pain, inflammation, and oxidative stress

  This trial will try giving an intravenous combination of lidocaine and dexmedetomidine during laparoscopic bariatric surgery in adults with obesity to see if it lowers pain, inflammation, and oxidative stress after surgery.

  Recruiting at 2 sites Phase 4 Instituto Mexicano del Seguro Social · Mexico City, Mexico City and 1 other locations · NCT07073846

• Sacral canal block to control blood pressure during hip replacement in older adults

  This will test whether giving a sacral canal block before hip replacement helps safely lower blood pressure during surgery for people over 45.

  Recruiting General Hospital of Ningxia Medical University · Yinchuan, Ningxia · NCT07064434

• RADA16 hydrogel use during adult tonsillectomy

  This trial will test whether applying RADA16 hydrogel during adult tonsillectomy reduces postoperative pain, bleeding, and the need for extra opioid medication.

  Recruiting Phase 3 Rutgers, The State University of New Jersey · Livingston, New Jersey and 1 other locations · NCT07060495

• Hemostatic methods in partial pulpotomy: sodium hypochlorite vs chlorhexidine vs cold saline

  This trial will try whether using 2.5% sodium hypochlorite, chlorhexidine, or cold saline to stop bleeding during partial pulpotomy changes post-procedure pain and whether the pulp remains healthy over 12 months.

  Recruiting Cukurova University · Adana, Sarıçam · NCT07058727

• Virtual reality or eye mask during dressing after coronary artery bypass

  This study tests whether wearing a virtual reality headset or an eye mask during dressing after coronary artery bypass surgery can reduce pain, anxiety, and stress-related vital sign changes in adults recovering from CABG.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Marmara · NCT07039812

• Optimal spinal morphine dose for pain after cesarean delivery

  This will test different doses of morphine given into the spinal fluid to find the best dose for reducing pain after an elective cesarean in adult women.

  Recruiting University of Ioannina · Ioannina, Epirus · NCT07023497

• Comparing dexmedetomidine plus ketamine doses for C-section pain

  This study will test three doses of dexmedetomidine given with a fixed ketamine dose to see which combination best controls pain after an elective cesarean section with the fewest side effects.

  Recruiting Phase 4 Fatima Memorial Hospital · Lahore, Punjab Province · NCT07022821

• Hilotherapy versus Kinesio taping for recovery after bimaxillary jaw surgery

  This study will test whether kinesio taping or hilotherapy reduces swelling, pain, and limited mouth opening in adults after bimaxillary orthognathic (jaw) surgery.

  Recruiting Medipol University · Istanbul, Bağcılar · NCT07006610

• Comparing drainage options after minimally invasive esophagectomy

  This trial tests three different drainage approaches after minimally invasive esophagectomy to see which leads to less postoperative pain and fewer complications for adults with esophageal cancer.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07004634

• PECS-II versus ESP nerve blocks for pain control during breast surgery

  This tests whether PECS-II or ESP nerve blocks better reduce intraoperative opioid use in adult women having elective breast surgery when anesthesia is guided by a Nociception Level Index monitor.

  Recruiting Koç University · Istanbul · NCT07002541

• How genetic differences affect nalbuphine pain relief after abdominal or pelvic surgery

  We will test whether genetic differences change how well nalbuphine relieves pain after abdominal or pelvic surgery in adults.

  Recruiting Phase 2/3 Ziauddin University · Karachi, Sindh · NCT06996561

• Comparing dexmedetomidine and bupivacaine for pain management after brain surgery

  This study is testing if adding dexmedetomidine to bupivacaine can help reduce pain better after brain surgery compared to using bupivacaine alone.

  Recruiting Ain Shams University · Cairo · NCT06993922

• Comparing two pain management techniques after lower abdominal surgery

  This study is testing which pain management technique, ultrasound-guided QL block or TAP block, works better for adults having lower abdominal surgery to help them feel more comfortable after their procedure.

  Recruiting Sohag University · Sohag · NCT06978179

• Deep rectus sheath block to reduce pain after laparoscopic gallbladder removal

  This trial will test whether adding a deep rectus sheath nerve block can reduce pain and opioid use after laparoscopic gallbladder removal in adults.

  Recruiting Istinye University · Istanbul · NCT06976320

• Investigating how serum calcium levels affect pain after abdominal surgery

  This study is testing if changes in calcium levels in the blood can affect how much pain people feel after having abdominal surgery.

  Recruiting The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06957158

• Impact of genetics on pain relief from NSAIDs before dental procedures

  This study tests how genetic differences affect the pain relief people feel from common pain medications before getting a root canal.

  Recruiting Ataturk University · Erzurum, Erzurum · NCT06937853

• Comparing pain management methods for ACL surgery

  This study is testing whether a new way of managing pain before ACL surgery works better than a traditional method to help patients recover more comfortably.

  Recruiting Ankara University · Ankara · NCT06936995

• Using noise cancelling headphones to reduce pain after gynecological surgery

  This study tests whether using noise cancelling headphones can help reduce pain after gynecological surgery for patients aged 18 to 55.

  Recruiting Maternal and Child Health Hospital of Hubei Province · Wuhan, Hubei · NCT06918470

• Evaluating anesthesia techniques for reducing inflammation in bariatric surgery

  This study tests different anesthesia methods during bariatric surgery to see which one helps reduce inflammation and supports better recovery for patients.

  Recruiting Hospital HM Nou Delfos · Barcelona, Barcelona · NCT06915558

• Investigating Lipid Levels and Pain After Breast Cancer Surgery

  This study is testing if the levels of fats in the blood can help predict how much pain women will have after breast cancer surgery.

  Recruiting Université Catholique de Louvain · Brussels, Brussels Capital · NCT06907810

• Ketamine during orthopedic trauma surgery to reduce pain, opioid use, and improve mood

  This study will try a single dose of ketamine during surgery to see if it lowers pain and opioid needs and improves depression and PTSD symptoms in adults having major orthopedic trauma surgery.

  Recruiting at 2 sites Phase 4 Texas Tech University Health Sciences Center · Lubbock, Texas and 1 other locations · NCT06903819

• Comparing two pain relief techniques for kidney surgery

  This study is testing two different pain relief methods for kidney surgery to see which one helps patients feel better and need fewer pain medications after their operation.

  Recruiting Cairo University · Maadi, Cairo Governorate and 1 other locations · NCT06892743

• Comparing two methods of pain control after kidney surgery in cancer patients

  This study is testing two different ways to control pain after kidney surgery in cancer patients to see which method works better.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT06889987

• New pain management technique for inguinal hernia surgery

  This study is testing a new way to manage pain after inguinal hernia surgery to see if it helps patients recover faster compared to standard pain relief methods.

  Recruiting Konya City Hospital · Konya · NCT06862609

• Comparing two pain management techniques after tummy tuck surgery

  This study tests which of two pain management techniques works better for people recovering from tummy tuck surgery.

  Recruiting Ankara Ataturk Sanatorium Training and Research Hospital · Ankara, Keçiören · NCT06845215

• TAP block versus wound infiltration to preserve breathing after laparoscopic kidney donation

  We will test whether a transversus abdominis plane (TAP) block or wound infiltration better preserves lung function in adults donating a kidney by laparoscopic surgery.

  Recruiting Rabin Medical Center · Petah Tikva · NCT06837909

• Comparing two pain relief methods for hip surgery

  This study is testing which pain relief method, a fascia iliaca block or a spinal injection of nalbuphine, works better for people recovering from hip surgery.

  Recruiting Ain Shams University · Cairo · NCT06818396

• Spinal morphine to reduce pain after planned caesarean section

  This trial will test whether adding a small dose of morphine to spinal anesthesia helps women having planned caesarean sections have less pain afterward without harming mother or baby.

  Recruiting at 9 sites Phase 4 Zealand University Hospital · Aarhus and 8 other locations · NCT06797973

• Comparing nerve blocks for pain management after shoulder surgery

  This study is testing three different ways to block pain after shoulder surgery to see which one helps patients feel better and recover faster.

  Recruiting Ain Shams University · Cairo · NCT06765278

• Evaluating thumbtack needle therapy for improving sleep and recovery after surgery

  This study is testing if thumbtack needle therapy can help women recover better and sleep more soundly after breast cancer surgery.

  Recruiting at 2 sites The First Affiliated Hospital of Xiamen University · Xiamen, Fujian and 1 other locations · NCT06757023

• Using Coenzyme Q10 to Reduce Pain After Lung Surgery

  This study is testing if Coenzyme Q10 can help reduce pain after lung surgery for adults aged 18-75.

  Recruiting Phase 4 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06743802

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Postoperative Pain Guidelines for Pregnancy: Safer, Patient-Centered Opioid Use

  We’re creating patient-friendly guidelines to help doctors manage pain after delivery and surgery in pregnant people, aiming to reduce opioid overuse and improve safety.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11624018

• Using smart devices to better understand and treat pain after surgery

  A Dartmouth-led project uses smartphones and wearables with smart AI to predict and manage persistent pain that can follow surgery.

  NIH research Dartmouth College · Hanover, United States · NIH-11426000

• Contemporary Human Models of Postoperative Pain in General Surgery

  A study in general surgery patients using biopsychosocial approaches to understand why some people have long-lasting pain after surgery.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11399880

• Better Predicting and Personalizing Postoperative Pain Care

  Aimed at using advanced data tools to better predict and manage a patient’s pain after surgery and reduce opioid-related risks.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11398952

• Central glutamate signaling in postoperative pain regulation

  This grant studies how brain circuits control pain after surgery to help develop non-opioid pain medicines for patients.

  NIH research New York University School of Medicine · New York, United States · NIH-11374456

• Extended-release gel for opioid-free postoperative pain relief

  A new injectable gel formulation of bupivacaine is being tested to provide pain relief for several days after surgery without using opioids.

  NIH research Sonoran Biosciences, INC. · Tempe, United States · NIH-11251964

• Better prediction and personalized control of pain after surgery

  This project builds computer tools to predict who will have bad pain after surgery and help doctors tailor pain control for patients recovering from operations.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11192819

• Understanding brain signals for pain after surgery

  This research aims to uncover how the brain processes pain after surgery to help develop new, non-opioid ways to manage it.

  NIH research New York University School of Medicine · New York, United States · NIH-11144431

• Investigating a new chemokine to reduce pain after surgery

  This study is looking at how a substance called CCL12 affects pain after surgery, and by blocking it, researchers hope to find a way to reduce pain without the side effects of opioids, making recovery easier for patients.

  NIH research Michigan State University · East Lansing, United States · NIH-11110017

• Injectable gel for long-lasting pain relief after surgery

  This study is testing a new injectable gel that helps relieve pain after surgery without using opioids, making recovery safer and more comfortable for patients dealing with moderate-to-severe pain.

  NIH research Sonoran Biosciences, INC. · Tempe, United States · NIH-11066703

• Using virtual reality and biofeedback to manage pain after surgery in kids

  This study is exploring a fun new way to help kids and teens feel better after surgery by using virtual reality and biofeedback, so they can manage their pain on their own and recover more comfortably.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11044480

• Creating guidelines for managing pain after surgery during pregnancy

  This study is working to create helpful guidelines for managing pain after surgery for pregnant people, so they can get the best care possible while making sure everyone is treated fairly, and it will be tested in hospitals across Michigan to see how well it works.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10995537

• Preventing pain after surgery using a new treatment approach

  This study is testing a new treatment called RFT1124 to help manage pain after surgery, aiming to provide relief without the side effects of traditional pain medications like opioids and NSAIDs.

  NIH research Raft Pharmaceuticals, LLC · San Diego, United States · NIH-10932172

• Understanding the genetic and neural factors behind chronic pain after surgery

  This study is looking into why some people experience long-lasting pain after surgery, especially after procedures like amputations and heart surgeries, and aims to find ways to predict who might be at risk and improve how we can prevent and treat that pain.

  NIH research University of Utah · Salt Lake City, United States · NIH-10836986

• Understanding and managing postoperative pain better.

  This study is looking at new ways to understand and manage pain after surgery, so that patients can get more personalized care and feel better during their recovery.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10773526

• Using advanced computer tools to improve pain management after surgery

  This study is looking at how to make pain relief after surgery better by using smart computer tools to understand patient records, so we can find out who might need different kinds of pain management to feel their best while they recover.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10684876

• Creating guidelines for managing pain after surgery during pregnancy

  This study is working to create helpful guidelines for managing pain after surgery for pregnant people, aiming to improve care and reduce the use of opioids by exploring other pain relief options.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10675810

Related topics

Quick answers

How many Postoperative Pain clinical trials are recruiting right now?

179, as of November 12, 2026. 9 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in Turkey (Türkiye) (70 trials), China (28 trials), Egypt (20 trials), United States (15 trials), Greece (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 16, Phase 2: 5, Phase 2/3: 3, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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