Comparison of two ultrasound-guided blocks for pain after modified radical mastectomy
Official title: Comparison of Postoperative Analgesic Efficacy of Superior Posterior Serratus Intercostal Plane Block (SPSIP) and Anterior Serratus Plane Block in Modified Radical Mastectomy Surgery
Run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT07737132 · Data updated 2026-11-12
This trial tests whether the serratus posterior superior intercostal plane block (SPSIPB) provides better postoperative pain relief than the serratus anterior plane block (SAPB) for women undergoing modified radical mastectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 70 (estimated) |
| Sponsor | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Academic / other |
| Locations | 1 site (Istanbul, Uskudar) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | February 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | October 23, 2026 |
| Trial ID | NCT07737132 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–65 years undergoing elective modified radical mastectomy, ASA I–III, BMI <35 kg/m², with normal coagulation and organ function, able to consent.
✕Probably not a fit
Patients with contraindications to regional anesthesia or those not experiencing adequate benefit from the block may not see an improvement in pain.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, randomized, double-blind, single-center study compares two ultrasound-guided regional anesthesia techniques used in multimodal analgesia for breast cancer surgery. Seventy female patients aged 18–65 years undergoing elective modified radical mastectomy under general anesthesia are assigned to receive either SPSIPB or SAPB. The primary goal is to assess postoperative analgesic efficacy, with safety and opioid-sparing effects evaluated as part of standard perioperative care. The trial aims to clarify whether SPSIPB offers superior pain control compared with the established SAPB in this surgical population.
Why it matters
Potential benefit: If SPSIPB proves superior, patients may experience better pain control and reduced opioid needs after surgery.
How similar studies have gone: Prior regional anesthesia studies show SAPB provides effective analgesia; SPSIPB is newer with promising but less extensive comparative evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 65 years. * Scheduled for elective modified radical mastectomy under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index (BMI) \<35 kg/m². * Normal coagulation profile (including INR and platelet count). * Normal liver and renal function tests. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics. * Coagulation disorders or bleeding diathesis. * Infection or inflammation at the planned block site. * ASA physical status IV or higher. * Chronic opioid use or chronic pain requiring long-term analgesic therapy. * Advanced hepatic or renal insufficiency. * Severe pulmonary disease. * Opioid use within 24 hours before surgery. * Cognitive impairment or inability to complete postoperative assessments. * Revision breast surgery. * Refusal to participate in the study.
Where it's running
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Sultan 2. Abdulhamid Han Training and Research Hospital
Istanbul, Uskudar, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Dilek M Yamac — Sultan Abdülhamid Han education and research hospital
- Study coordinator: Dilek M Yamac, MD
- Email: ddilekmetin@hotmail.com
- Phone: +905054959792
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.