Clinical trial Recruiting at 1 site Interventional Ages 18 to 65 Women only

Intraperitoneal spray plus IV lidocaine to reduce pain after laparoscopic myomectomy

Official title: The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy

Run by General Hospital of Ningxia Medical University · NCT07268495 · Data updated 2026-11-12

This will test whether using a lidocaine spray inside the abdomen plus IV lidocaine reduces pain after laparoscopic myomectomy in adults.

More Postoperative Pain trials

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexWomen only
Enrollment100 (estimated)
SponsorGeneral Hospital of Ningxia Medical University
Academic / other
Locations1 site (Yinchuan, Ningxia)
StatusRecruiting
StartedAugust 1, 2024
Main results expectedAugust 1, 2025
Study endsDecember 20, 2025
Registry record updatedDecember 5, 2025
Trial IDNCT07268495 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–65 with ASA physical status I–III scheduled for laparoscopic myomectomy who can give informed consent and do not have severe organ disease, chronic pain, arrhythmia, or lidocaine allergy.

Probably not a fit

Patients with expected surgery durations over 3 hours, those converted to open surgery, those allergic to lidocaine, or those with severe hepatic/renal/cardiac disease, chronic pain, or arrhythmia are unlikely to benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing laparoscopic myomectomy under general anesthesia are assigned to one of four intraoperative treatments combining intravenous and intraperitoneal lidocaine or saline. Pain after surgery will be compared between the groups to see if the combined route lowers postoperative pain. Eligible participants are aged 18–65 with ASA I–III and provide informed consent, while those with long surgeries or certain comorbidities are excluded. The trial is conducted at the General Hospital of Ningxia Medical University in Yinchuan.

Why it matters

Potential benefit: If successful, the approach could reduce postoperative pain and lower the need for opioid pain medicines after laparoscopic myomectomy.

How similar studies have gone: Previous trials of either intravenous or intraperitoneal lidocaine in laparoscopic procedures have shown mixed but often favorable effects on postoperative pain.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age:18-65 years old;
2. ASA physical status classification I - III;
3. Undergoing laparoscopic hysteromyoma resection under general anesthesia;
4. The patient has been informed and has signed the informed consent form.

Exclusion Criteria:

1. Surgery duration exceeding 3 hours;
2. Need for additional surgery;
3. Allergy to the study drugs;
4. Presence of severe psychological,hepatic,renal,and cardiac diseases;
5. History of chronic pain or arrhythmia.

Elimination Criteria:

1. The patient or their family withdraws from or refuses to participate in the trial during the observation period;
2. Conversion from laparoscopy to laparotomy or change in surgical approach during the procedure.

Where it's running

  • General Hospital of Ningxia Medical University
    Yinchuan, Ningxia, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.