Bupivacaine with Epinephrine Sprayed Under the Diaphragm During Laparoscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional Phase 4 trial investigates whether applying a bupivacaine with epinephrine spray over the diaphragm can lessen shoulder pain after benign gynecologic laparoscopy. Eligible patients are adults and children 8 years or older undergoing laparoscopic surgery at Cedars-Sinai who consent and meet other criteria. Participants are randomized to receive the diaphragmatic spray of bupivacaine with epinephrine versus placebo (saline), with outcomes focused on postoperative shoulder discomfort. The study is conducted at Cedars-Sinai Medical Center, with the sponsor and site coordinating perioperative care. The goal is to determine if this targeted local anesthetic approach improves pain control after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provide a signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study
* 8 years of age or older
* Undergoing laparoscopic surgery at Cedars-Sinai Medical Center with a surgeon in the Minimally Invasive Gynecologic Surgery division.

Exclusion Criteria:

* Pregnancy
* Urgent/non-scheduled surgery
* Scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure)
* Baseline shoulder pain
* Baseline opioid use
* Baseline of chronic pain syndrome
* Conversion to open surgery
* Allergy or intolerance to bupivacaine, lidocaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen
* Planned post-operative admission

Where it's running

• Cedars Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Ogechukwu Ezike, MD
• Email: ogechukwu.ezike@cshs.org
• Phone: 3473371181

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

• Functional electrical stimulation plus shoulder exercises for older adults with rotator cuff pain

  In older adults with rotator cuff–related shoulder pain, this study tests whether adding functional electrical stimulation to a shoulder exercise program improves muscle coordination and reduces impingement compared with exercises alone.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07886827

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.