Liposomal Bupivacaine TAP Block Plus Pain Control to Help Gut Recovery After Major Abdominal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, double-blind study enrolling adults 18-80 with ASA I-III undergoing elective small bowel or colorectal surgery. Participants are assigned to three postoperative analgesia regimens: R-S (ropivacaine TAP block with sufentanil PCIA), LB-S (liposomal bupivacaine TAP block with sufentanil PCIA), or LB-O (liposomal bupivacaine TAP block with oxycodone PCIA). The primary outcome is the AUC of the I-FEED score, a measure of postoperative gastrointestinal recovery. The trial aims to determine if the liposomal bupivacaine TAP block improves GI recovery and safety compared with standard regimens. Eligible patients must consent and comply with assessments; several medical exclusions apply.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled to undergo elective major abdominal surgery, specifically small bowel or colorectal resections.
* Aged between 18 and 80 years (inclusive).
* American Society of Anesthesiologists (ASA) physical status I, II, or III.
* Capable of understanding the study procedures, cooperating with postoperative pain/recovery assessments (e.g., VAS, QoR-15, I-FEED), and providing written informed consent prior to surgery.

Exclusion Criteria:

* History of significant neuropsychiatric disorders, including schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, that may interfere with pain perception or cognitive evaluation.
* History of alcohol abuse or chronic opioid/analgesic dependence.
* Severe, uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg).
* Severe cardiac, hepatic, renal, or pulmonary dysfunction that poses a high surgical/anesthetic risk or alters drug metabolism.
* Pregnant or lactating women.
* Known allergy, hypersensitivity, or contraindications to any of the study medications, including local anesthetics (ropivacaine, bupivacaine) or opioids (sufentanil, oxycodone).

Where it's running

• Tianjin First Central Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Ke yu Zhang
• Email: m456365zky@163.com
• Phone: +86 19861121816

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.