Intrathecal Morphine or Dexmedetomidine for Pain After Spine Fixation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares intrathecal morphine and intrathecal dexmedetomidine to placebo in adults undergoing elective lumbar spine fixation. It aims to determine which intrathecal agent provides better postoperative pain relief and how each affects recovery. The design involves three arms and focuses on perioperative safety and analgesic efficacy in a spine surgery population. Perioperative factors such as blood loss and pain intensity are considered, with attention to potential drug-specific side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged between 21 and 60 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) Physical Status I or II.
* Scheduled for elective lumbar spine fixation surgery under general anesthesia.

Exclusion Criteria:

* Patients' refusal.
* Decompensated hepatic or renal or cardiac disease.
* Coagulation disorder.
* Pregnancy and lactation.
* Body mass index above 30 kg/m2.
* Severe pulmonary disorders.
* Patients on opioid, alcohol or allergy to any of the study drugs.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Abdelhamed I Badreldin, MSc
• Email: bedobadr30@gmail.com
• Phone: 00201090690631

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.