QLESP Block to Ease Pain After Robot-Assisted Kidney Surgery
Official title: Ultrasound-Guided L2 Level QLESP Block for Postoperative Analgesia in Robot-Assisted Partial Nephrectomy: A Prospective Randomized Controlled Trial
Run by Huazhong University of Science and Technology · NCT07704970 · Data updated 2026-11-12
Doctors are testing a ultrasound-guided nerve block called QLESP to see if it lowers pain and reduces strong pain medicines after robotic partial nephrectomy in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Huazhong University of Science and Technology Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | September 22, 2026 |
| Main results expected | February 28, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07704970 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–75 scheduled for elective robot-assisted partial nephrectomy, with ASA I–III and BMI 18–35 kg/m², who can consent and use pain scoring and PCA.
✕Probably not a fit
Patients with contraindications to local anesthetics or opioids, language barriers, coagulation problems, neuropathies, or significant organ dysfunction may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial compares QLESP nerve block with standard local wound injections in adults undergoing robot-assisted partial nephrectomy for kidney cancer. Participants are randomly assigned to receive the QLESP block or wound-only injections before surgery and then use a patient-controlled analgesia pump for 48 hours postoperatively. Pain scores and recovery quality are measured at multiple time points within the first 72 hours and again until hospital discharge. The study aims to determine if QLESP can decrease opioid use and improve early recovery.
Why it matters
Potential benefit: If successful, QLESP could lessen opioid needs and improve early recovery after robotic kidney surgery.
How similar studies have gone: Previous work in regional blocks for abdominal or kidney surgeries has shown potential for pain reduction, but results for QLESP in RAPN are still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 to 75 years * Scheduled for elective robot-assisted partial nephrectomy (RAPN) * American Society of Anesthesiologists (ASA) physical status I to III * Body mass index (BMI) 18 to 35 kg/m² * Voluntarily signed informed consent form Able to understand pain scoring and use of patient-controlled analgesia (PCA) Exclusion Criteria: * Language, communication, or comprehension barriers * Infection at the intended puncture site * Coagulopathy or bleeding diathesis * Known allergy or contraindication to local anesthetics or opioids * Use of analgesic medications within the past 3 months * Peripheral neuropathy * Severe cardiac, hepatic, or renal dysfunction * Pregnancy or breastfeeding * Refusal to participate in the study
Where it's running
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China Recruiting
Study contacts
- Study coordinator: Xi Wu
- Email: wu2018whuh@163.com
- Phone: +8615871715431
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.