Condition

Pain Management clinical trials and research

• 102Clinical trials
• 99NIH research projects
• 3New in 30 days
• 28Countries

Newest Pain Management clinical trials

All recruiting trials (102)

• Dexmedetomidine as add-on for refractory cancer pain in palliative care

  This study tests whether adding dexmedetomidine helps improve pain control for adults with cancer in palliative care whose pain remains high despite opioids.

  Recruiting St. Olavs Hospital · Drammen and 3 other locations · NCT07885475

• Two Ways to Help Pain After Breast Surgery: Education-Based Analgesia vs Standard Care

  This trial tests whether teaching patients about pain management and using a multimodal pain plan improves pain control and recovery after breast surgery compared with standard care.

  Recruiting University General Hospital of Heraklion · Heraklion, Crete · NCT07880223

• Virtual Reality Therapy to Improve Arthroplasty Outcomes

  This pilot test checks whether using virtual reality during the perioperative period helps knee or hip replacement patients feel better about their care and recover more easily.

  Recruiting NHS Highland Research, Development and Innovation Organisation · Inverness, Highlands · NCT07872670

• Suzetrigine for pain relief after knee replacement

  This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT07864896

• Analgesic effects of adding BiFeS block to adductor canal block after ACL reconstruction

  This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after ACL reconstruction.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07859397

• Tegileridine for pain after bariatric surgery

  This phase 3 trial tests tegileridine vs standard opioid medicine to see if it provides good pain relief after bariatric surgery while considering sleep apnea status.

  Recruiting Phase 3 The First Hospital of Jilin University · Changchun, Jilin · NCT07844512

• Effect of extraction site and local anesthesia on pain after laparoscopic appendectomy

  This study tests whether using the periumbilical versus left lower quadrant extraction site and routine port-site local anesthesia affect postoperative pain in adults with acute appendicitis undergoing laparoscopic appendectomy.

  Recruiting Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır, Kayapınar · NCT07824908

• QLESP Block vs PENG+LFCN Block for Total Hip Arthroplasty

  This trial tests whether the QLESP nerve block provides better pain relief after hip replacement than the standard PENG+LFCN blocks.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT07771829

• Distraction Methods to Ease Pain and Fear During a Child’s Blood Draw

  This study tests if pinwheel blowing, a 3D hologram, or sugar-free gum can reduce pain and fear during blood draws for kids aged 5–10 compared with routine procedure.

  Recruiting Corlu State Hospital · Tekirdağ · NCT07770191

• Safinamide added to standard therapy for PD-related pain

  This Phase 3 trial tests whether safinamide, added to usual Parkinson’s medication, reduces PD-related pain more than placebo in adults with motor fluctuations and chronic pain.

  Recruiting Phase 3 Universita di Verona · Verona, Veneto · NCT07761936

• Home-based assessment and treatment to avoid hospital admission for nursing home residents

  This study tests whether on-site care by municipal teams can safely reduce hospital visits for nursing home residents who become acutely ill or deteriorate after hours.

  Recruiting at 4 sites Copenhagen University Hospital at Herlev · Copenhagen and 3 other locations · NCT07756554

• Vibration and ShotBlocker to Reduce Pain and Fear During IM Injections in Children

  This randomized trial tests whether vibration or a ShotBlocker reduces pain and fear for 5- to 10-year-olds receiving intramuscular injections in the emergency department.

  Recruiting Burdur Mehmet Akif Ersoy University · Burdur · NCT07750626

• Rectointercostal plane block to reduce pain after laparoscopic gallbladder removal

  This study tests whether giving a rectointercostal block during laparoscopic cholecystectomy can lower postoperative pain for patients without changing general anesthesia.

  Recruiting Istinye University · Istanbul · NCT07745972

• Anterior suprascapular and axillary nerve blocks plus diaphragm-friendly approach for shoulder surgery

  This study tests whether a diaphragm-sparing anterior suprascapular plus axillary nerve block provides pain relief for shoulder surgery as well as or better than the standard interscalene block.

  Recruiting Ankara Etlik City Hospital · Yenimahalle, Ankara · NCT07739303

• Breast milk and sugar solutions to ease heel-prick pain in premature babies

  This study tests whether oral breastfeeding or sugary solutions help relieve pain in premature newborns during a heel-prick blood draw.

  Recruiting Mersin University · Mersin · NCT07716813

• Analgesia with Ultrasound-Guided Deep Iliacus Plane Block for Hip Fracture Surgery

  This study tests whether adding an ultrasound-guided deep iliacus plane block after hip fracture surgery helps control pain better than a sham block when patients also use standard pain medicines.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Istanbul, Istanbul · NCT07716540

• Understanding brain changes in chronic pancreatitis pain

  This study tests whether central nervous system changes and neuropsychological factors help explain persistent pain in adults with chronic pancreatitis.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT07707609

• Quadro-Iliac Plane Block to Ease Pain After Lumbar Microdiscectomy

  This trial tests whether a bilateral ultrasound-guided quadro-iliac plane block, added to standard pain medicine, reduces the amount of fentanyl needed in the first 24 hours after single-level lumbar microdiscectomy compared with local infiltration analgesia.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Istanbul, Istanbul · NCT07695987

• Enhanced Music and Natural Visuals for Emotional Health

  This trial tests whether using soundBrilliance software with music and natural visuals helps improve emotional health for people 13 and older.

  Recruiting at 3 sites soundBrilliance LLC · Fort Collins, Colorado and 2 other locations · NCT07676110

• Impact of a Parasternal Intercostal Block on Internal Thoracic Artery Harvest in CABG

  This study tests whether a superficial parasternal intercostal plane block can improve the ITA caliber and help surgeons harvest the graft during CABG.

  Recruiting Phase 3 Ain Shams University · Cairo, Cairo Governorate · NCT07663435

• Dexketoprofen given by IV to see if it reduces rebound pain after shoulder block

  This study tests whether giving an IV dose of dexketoprofen after shoulder surgery can lessen or prevent rebound pain when a nerve block wears off.

  Recruiting Eskisehir Osmangazi University · Eskişehir, Odunpazarı · NCT07642674

• Combined distal femoral nerve block for pain relief after knee replacement

  This study tests whether using a combined distal femoral nerve block after knee replacement reduces opioid needs while keeping leg strength intact.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Dijon · NCT07629388

• Analgesia for knee arthroscopy: adductor canal block alone vs with BiFeS block

  This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after knee arthroscopy in adults.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07603323

• Brief audio-guided mindfulness for pain in orthopedic waiting rooms

  This trial tests whether listening to short mindfulness audio clips can help reduce pain for adults waiting for orthopedic care.

  Recruiting Florida State University · Tallahassee, Florida · NCT07562412

• Pain medication needs in the first hours after elective surgery in the PACU

  This study will see which patient, surgery, and anesthesia factors are linked to how much pain medicine adults need immediately after elective surgery while in the post-anesthesia care unit (PACU).

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Ankara, Yenimahalle · NCT07547618

• Transversalis fascia plane block to reduce pain after kidney transplant

  See if a transversalis fascia plane block can reduce pain and opioid use after kidney transplant for adults aged 18–65 with ASA III.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT07542028

• PancreasPlus app for monitoring recovery, symptoms, and education after pancreatic cancer treatment

  This project will test whether the PancreasPlus app helps adults with pancreatic cancer and their caregivers monitor symptoms, get timely information, and communicate with their healthcare team.

  Recruiting Casa di Cura Dott. Pederzoli · Pavia, Pavia and 1 other locations · NCT07532590

• Giving Children a Voice in Pediatric Anesthesia

  This project tests whether asking children, parents, and clinicians about priorities can shape future pediatric anesthesia research in Switzerland.

  Recruiting at 7 sites Insel Gruppe AG, University Hospital Bern · Aarau, Canton of Aargau and 6 other locations · NCT07524049

• Remotely Delivered Pilates for MS: Walking, Balance, Fatigue, Mood and Quality of Life

  A 16-week remote Pilates program will be tested to see if it helps walking, balance, fatigue, pain, mood, thinking, and quality of life for people with multiple sclerosis who can participate from home.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07504120

• Pain and moderate exercise in midlife former athletes, masters athletes, and nonathletes

  This trial tests if moderate-intensity strength versus aerobic exercise changes pain before and after workouts in adults aged 35–65 who are former competitive athletes, current master's athletes, or nonathletes.

  Recruiting Marquette University · Milwaukee, Wisconsin · NCT07502742

• BETY with intra-articular injections for knee osteoarthritis

  This will try whether adding BETY to intra-articular knee injections reduces pain and improves function in adults with stage 2 or 3 knee osteoarthritis.

  Recruiting Hacettepe University · Ankara, Samanpazarı · NCT07496203

• Prevalence of central sensitization signs in adults with ASD without intellectual disability

  This project will see how common signs of central sensitization—which can change how pain is felt—are in adults with autism spectrum disorder who do not have intellectual disability.

  Recruiting Groupe Hospitalier Mutualiste de Grenoble · Grenoble, Isere · NCT07495761

• Paracervical Block With Ketorolac and Lidocaine for Osmotic Dilator Placement

  This study tests whether a ketorolac and lidocaine injection around the cervix improves pain control for people needing osmotic dilators before a second-trimester abortion.

  Recruiting Phase 2 Rush University Medical Center · Chicago, Illinois · NCT07487246

• Comparing a single erector spinae block to parasternal plus serratus blocks for pain after sternotomy

  We will see if a single erector spinae nerve block or a combination of superficial parasternal and serratus anterior blocks better controls pain and reduces opioid use in adults having elective open‑chest (sternotomy) heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07472296

• Anterior iliopsoas space block versus PENG block to make positioning for spinal anesthesia easier in people having hip surgery

  This trial will test whether an anterior iliopsoas space block or a PENG block makes it easier to position adults having hip surgery for spinal anesthesia.

  Recruiting Phase 3 Benha University · Banhā, Elqalyoubea · NCT07467356

• Long-acting liposomal bupivacaine for pain after hemorrhoid surgery

  This test tries whether injecting long-acting liposomal bupivacaine around the surgical site reduces postoperative pain for adults having elective hemorrhoid surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07442539

• Quadro-iliac plane block versus TAP block for pain after inguinal hernia surgery

  In adults undergoing unilateral inguinal hernia repair, this study tests whether the Quadro-iliac Plane Block provides better postoperative pain relief than the Transversus Abdominis Plane Block.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07442188

• Liposomal bupivacaine for rhomboid intercostal nerve block to reduce pain after VATS

  We will test whether adding long‑acting liposomal bupivacaine to a rhomboid intercostal nerve block reduces pain after video‑assisted thoracoscopic lung surgery in adults.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07441902

• Liposomal bupivacaine to reduce pain after VATS

  This test will see if a long‑acting liposomal bupivacaine injection at the incision eases postoperative pain for adults having VATS lung surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07432711

• Ketamine to reduce shoulder pain after laparoscopic gastric sleeve

  This trial will try giving ketamine during surgery to see if it reduces shoulder pain after gastric sleeve operations for adults with obesity.

  Recruiting Early Phase 1 King Abdullah University Hospital · Irbid · NCT07429916

• Continuous nefopam infusion after pancreatoduodenectomy

  This trial will test whether a continuous infusion of nefopam can lower opioid use and reduce pain for people having a pancreatoduodenectomy.

  Recruiting Phase 4 Iuliu Hatieganu University of Medicine and Pharmacy · Cluj-Napoca, Cluj · NCT07423650

• Ultrasound-guided Quadro-Iliac Plane block for pain after total hip replacement

  This trial will test whether an ultrasound-guided Quadro-Iliac Plane (QIP) block reduces opioid use and pain in adults having elective primary total hip arthroplasty.

  Recruiting Bursa City Hospital · Bursa · NCT07410000

• Tracking early pain and recovery after a limb amputation

  This project will look at early post‑operative pain and functional recovery in adults who had a limb amputation to see how pain changes and what factors are linked to better or worse recovery.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT07393139

• Peripheral autonomic plus TAP blocks for pain after minimally invasive left-sided colorectal surgery

  This will try adding a peripheral autonomic block (targeting the superior hypogastric and inferior mesenteric plexuses) plus a TAP block to standard pain control in adults having elective minimally invasive left-sided colorectal surgery to see if it reduces pain and opioid use in the first 48 hours.

  Recruiting Faculdade de Ciências Médicas de Minas Gerais · Belo Horizonte, Minas Gerais · NCT07388953

• Metamizole (Optalgin) impact on anti‑Xa levels in cancer patients on apixaban or rivaroxaban

  This study will test whether taking metamizole (Optalgin) changes anti‑Xa blood levels in adults with cancer who are taking apixaban or rivaroxaban.

  Recruiting Rambam Health Care Campus · Haifa · NCT07384013

• Managing acute chest pain after combat-related thoracic injuries in Ukraine

  This study will test whether cryoablation or radiofrequency ablation better controls severe chest pain and speeds recovery in adults with combat-related chest injuries treated at Ukrainian hospitals.

  Recruiting Lviv National Medical University · Rivne · NCT07380789

• Opioid-free anesthesia as an option for people having laparoscopic pancreatic surgery

  This trial tests whether opioid-free anesthesia can reduce or avoid opioid use after laparoscopic peripheral pancreatic resection while keeping pain under control.

  Recruiting at 2 sites Jagiellonian University · Krakow, Lesser Poland Voivodeship and 1 other locations · NCT07378189

• Comparing fixed-rate versus time-programmed decreasing IV PCA after surgery

  This trial will try two different IV patient-controlled analgesia infusion methods to see which reduces opioid use and improves pain control for adults after elective mixed surgery.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07375121

• Low-dose ketamine for sickle cell vaso-occlusive pain in children and young adults

  This trial will test whether adding a low (sub-dissociative) dose ketamine infusion to usual IV opioid pain medicine helps children and young adults (ages 5–20) with sickle cell disease have better pain relief and remain safe during a vaso-occlusive episode.

  Recruiting Phase 2 Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, California · NCT07369024

• Opioid-free anesthesia for duodenopancreatic surgery by laparotomy

  This study tests whether opioid-free anesthesia can provide effective pain control for adults undergoing pancreaticoduodenal surgery with laparotomy.

  Recruiting Jagiellonian University · Krakow, Lesser Poland Voivodeship · NCT07364864

• Comparing adjustable feedback IV patient-controlled pain pumps with fixed-rate pumps after surgery.

  This study will test whether an adjustable feedback IV patient-controlled pain pump can reduce opioid use and improve pain control compared with a fixed-rate pump for adults having elective surgeries.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07361822

• Parasternal plane block to reduce pain signals during pediatric median sternotomy

  This will test whether an ultrasound-guided parasternal plane block can reduce intraoperative pain signals in children aged 6 months to 7 years undergoing heart surgery with a median sternotomy.

  Recruiting Diskapi Yildirim Beyazit Education and Research Hospital · Ankara · NCT07354750

• Opioid-sparing pain plan after anterior total hip replacement

  This study will test whether a reduced-opioid pain plan after anterior total hip replacement lowers opioid use while keeping pain well controlled for adults with osteoarthritis.

  Recruiting Phase 3 Emory University · Atlanta, Georgia · NCT07348627

• M‑TAPA versus TAP block for pain after one-sided open inguinal hernia repair

  We will test whether an M‑TAPA block or a TAP block gives better pain relief after elective unilateral open inguinal hernia surgery in adults aged 18–65.

  Recruiting Erzurum Regional Training & Research Hospital · Erzurum · NCT07311902

• PARO robot to ease pain and anxiety during IV placement in young children

  This trial will test whether adding the PARO therapeutic robot to usual pain care helps children aged 12 months to 7 years feel less pain and anxiety during peripheral IV placement.

  Recruiting at 2 sites Fondation Lenval · Brest and 4 other locations · NCT07299006

• Virtual reality to reduce pain and anxiety during first-trimester procedural abortion

  This trial will test whether wearing a VR headset that shows a meditative nature video during a first-trimester procedural abortion reduces pain and anxiety and increases satisfaction compared with usual care.

  Recruiting at 2 sites University of Pittsburgh · Pittsburgh, Pennsylvania and 1 other locations · NCT07288047

• TENS at two acupuncture points and its immediate effects on pain-related brain signals

  This sees if TENS applied to two acupuncture points (Zhongzhu SJ3 and Hegu LI4) changes pain-related brain signals in healthy adults.

  Recruiting China Medical University Hospital · Taichung, Beitun, Taiwan · NCT07267052

• IV tramadol plus paracetamol versus IM pethidine for pain relief during the first stage of labor

  This trial will test whether IV tramadol (100 mg) combined with paracetamol (1,000 mg) relieves pain better and with fewer side effects than 75 mg IM pethidine for women in the first stage of labor.

  Recruiting HaEmek Medical Center, Israel · Afula · NCT07264309

• Suzetrigine for pain control after primary total hip replacement

  This will test whether taking Suzetrigine before surgery and for seven days afterward reduces opioid use and improves pain control in adults having a primary total hip replacement.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT07226700

• Compare submucosal dexamethasone versus methylprednisolone after parasymphysis mandible repair

  This research will try to see whether a single submucosal dose of dexamethasone or methylprednisolone better reduces pain, swelling, and jaw stiffness after surgical repair of parasymphysis mandibular fractures in adults aged 18–40.

  Recruiting Phase 2 Nishtar Medical University · Multan, Punjab Province · NCT07208799

• Sedation before ultrasound-guided spinal anesthesia to reduce back pain after surgery.

  This trial will test whether giving midazolam before ultrasound-guided spinal anesthesia lowers the chance of new or persistent back pain after elective lower abdominal or leg surgery in adults.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07198412

• Imagined acupuncture for postoperative pain after spine surgery

  A 30-minute video-guided imagined acupuncture session delivered daily for 7 days after spine surgery is being tested to see if it helps reduce pain and opioid use for adults.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07197710

• Lifestyle medicine program for older adults with chronic musculoskeletal pain

  This program will test whether four face-to-face health coaching sessions about lifestyle changes can reduce pain and improve quality of life for older adults with chronic musculoskeletal pain.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07194239

• Deep brain stimulator battery replacement for people with Parkinson's disease

  This trial tests whether having a DBS battery replacement under regional chest-wall nerve blocks works as well and is as safe as having it under general anesthesia for people with Parkinson's disease aged 40–85.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07176494

• Standardized breathing control during rheumatological injections

  This trial will try whether a 5-minute guided breathing exercise can reduce pain and anxiety during ultrasound-guided joint or periarticular injections for people having rheumatological injections, compared with local lidocaine anesthesia.

  Recruiting Centre Hospitalier Metropole Savoie · Chambéry · NCT07172984

• Methylprednisolone taper plus standard pain medicines after ACL repair

  We will try adding a methylprednisolone dose-pack to usual pain medicines after ACL repair to see if it lowers pain and reduces opioid use for people aged 13 to 50.

  Recruiting Phase 4 St. Louis University · St Louis, Missouri · NCT07158476

• Two ultrasound-guided infraclavicular nerve block techniques for hand and forearm surgery

  This study tests whether the retroclavicular or the conventional ultrasound-guided infraclavicular nerve block works better for adults with obesity having forearm or hand surgery.

  Recruiting Ankara Etlik City Hospital · Yenimahalle, Ankara · NCT07151443

• Pain control with rectus sheath block versus caudal epidural block after minimally invasive inguinal hernia repair in children

  This study will test whether a rectus sheath block or a caudal epidural block provides better pain relief for children aged 1–8 having minimally invasive inguinal hernia repair (PIRS).

  Recruiting Diskapi Yildirim Beyazit Education and Research Hospital · Altındağ, Ankara · NCT07147062

• Digital self- and remote monitoring for chronic pain in primary care to improve quality of life

  This study will test whether adults with chronic pain can use the Paindrainer app and CARE portal to better monitor their symptoms and activity and improve quality of life while managed in primary care.

  Recruiting Lund University · Malmö, Skåne County · NCT07141108

• Moderate-intensity aerobic and resistance exercise to reduce pain sensitization in breast cancer survivors

  This program will try a supervised moderate-intensity aerobic plus resistance exercise regimen to see if it reduces pain sensitization and persistent upper-limb pain in breast cancer survivors.

  Recruiting Universidad Rey Juan Carlos · Madrid · NCT07128030

• Spinal (intrathecal) morphine versus bi-level erector spinae plane block for pain after living liver donation

  This will try spinal (intrathecal) morphine versus a bi-level erector spinae plane block to reduce pain and opioid use in living liver donors after hepatectomy.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT07123740

• Mapping sensations from spinal cord stimulation in people with chronic pain

  This project tries to identify the sensations spinal cord stimulation produces and see how those sensations change when stimulation settings are adjusted in adults receiving SCS for chronic pain.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07095036

• R.E.C.K versus Exparel for pain control during robotic kidney removal

  This will test whether intraoperative R.E.C.K or Exparel gives better pain control and reduces opioid use in adults having robotic partial or radical nephrectomy.

  Recruiting Phase 3 Wake Forest University Health Sciences · Charlotte, North Carolina · NCT07092566

• Virtual reality to distract from pain and anxiety during blood cancer procedures

  This project tries whether wearing a virtual reality headset during procedures can reduce pain and anxiety for people aged 6 and older with blood cancers.

  Recruiting University of Sfax · Tunis, Sfax Governorate · NCT07085065

• Multimodal versus narcotic pain control after rotator cuff repair

  This trial will test whether a mostly non‑narcotic multimodal pain plan reduces opioid use and keeps patients comfortable after arthroscopic rotator cuff repair.

  Recruiting Phase 4 Montefiore Medical Center · The Bronx, New York · NCT07076069

• VMD-3866 topical gel for chemotherapy-induced nerve pain

  This trial will test whether a non-opioid topical gel called VMD-3866 can reduce pain in adults with chemotherapy-induced peripheral neuropathy.

  Recruiting Phase 2 VM Therapeutics LLC · London, UK · NCT07072468

• Continuous versus bolus ibuprofen for pain after laparoscopic surgery

  This trial tests whether giving ibuprofen as a continuous infusion instead of intermittent bolus doses reduces pain and opioid use for adults having elective laparoscopic surgery.

  Recruiting Phase 4 Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Moscow, Moscow Oblast · NCT07070050

• Breathing exercises to reduce pain and improve recovery after transplant

  This project will try breathing exercises with adults aged 18–65 having their first transplant to see if they reduce pain and improve early recovery.

  Recruiting Ankara Yildirim Beyazıt University · Ankara · NCT07067580

• Electronic versus conventional dental syringes for reducing pain and anxiety during local anesthesia in children

  This test will see if electronic dental syringes cause less pain and anxiety than conventional syringes in children aged 6–8 during local anesthetic injections.

  Recruiting Ain Shams University · Cairo · NCT07045116

• Morbidity and mortality after serratus anterior plane block for unilateral anterolateral rib fractures

  This study tests whether giving a serratus anterior plane block (SAPB) within 24 hours to adults with multiple unilateral anterolateral rib fractures can reduce complications like pneumonia, shorten hospital stay, improve discharge outcomes, and lower death compared with usual opioid-based pain control.

  Recruiting Albert Einstein College of Medicine · The Bronx, New York · NCT07032766

• E-tailored pain management support for family caregivers of people with dementia using the PACE-app

  This trial tests whether the PACE-app, a web-based tool, can help family caregivers of people with dementia better manage their loved ones' chronic pain and improve caregiver confidence, communication, and well-being compared with usual care.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07032350

• Online psychological treatments for chronic pain in teens

  This study is testing if online therapy and education about pain can help teens aged 13-19 who have been dealing with chronic pain for at least three months feel better and improve their daily lives.

  Recruiting Region Stockholm · Vallentuna · NCT06981312

• Kinesiotaping and peloid (therapeutic mud) therapy for carpal tunnel syndrome

  This study will see if adding kinesiotaping or peloid (therapeutic mud) therapy to a home exercise program helps adults with mild to moderate carpal tunnel syndrome reduce pain and improve hand function.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya · NCT06977321

• Evaluating how well fentanyl patches work in unstable ICU patients

  This study tests how well fentanyl patches work for pain relief in critically ill ICU patients who are either unstable and need extra support or stable and don’t.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv, Israel · NCT06966869

• Music during catheter ablation for atrial fibrillation under light sedation

  This test will see if playing music during catheter ablation helps adults having their first atrial fibrillation procedure feel less anxious and in less pain while using light sedation.

  Recruiting Shaoxing People's Hospital · Shaoxing, Zhejiang · NCT06953752

• Using sublingual sufentanil for managing moderate to severe pain in emergencies.

  This study is testing if a new way of giving sufentanil under the tongue can help adults with moderate to severe pain from injuries feel better faster in emergency situations compared to regular pain management methods.

  Recruiting Phase 3 University Hospital, Clermont-Ferrand · France · NCT06917651

• Lower-dose IV ketorolac for pain control in adults in the ICU

  This pilot tests whether adding low-dose intravenous ketorolac to usual care can safely reduce opioid use for adults with pain in the ICU.

  Recruiting Phase 3 University of Alberta · Edmonton, Alberta · NCT06819956

• Evaluating physical therapy for endometriosis pain management

  This study is testing if a mix of education about pain and specific exercises can help women with endometriosis feel less pain and improve their quality of life.

  Recruiting University of Seville · Seville · NCT06795243

• Preoperative fear and its effect on postoperative pain and recovery

  This research tries to see if fear or anxiety before scheduled surgery makes postoperative pain worse or affects recovery in adults having planned operations.

  Recruiting Hospital Universitario de Gran Canaria Doctor Negrín · Las Palmas de Gran Canaria, Las Palmas · NCT06785389

• Minimum steroid dose added to incision anesthesia to reduce pain after spine surgery

  This trial tests whether adding different low doses of betamethasone to ropivacaine injected into the incision reduces pain after spine surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06785350

• Comparing intrathecal morphine and continuous wound infiltration for pain relief after pancreatic surgery

  This study is testing whether a single injection of morphine into the spine can help manage pain better than a continuous pain relief method after pancreatic surgery for adults.

  Recruiting Seoul National University Hospital · Seoul, Seoul · NCT06761989

• Using NSAIDs for pain management during pleurodesis procedures

  This study tests whether using a common pain reliever during pleurodesis can help reduce pain for patients with pneumothorax without causing more problems.

  Recruiting Phase 2 Centre Hospitalier Universitaire, Amiens · Amiens · NCT06731647

• Using psilocybin to help manage chronic neuropathic pain

  This study is testing if psilocybin can help adults with chronic nerve pain find relief when other medications haven't worked.

  Recruiting Phase 2 Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT06731335

• Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine

  This trial will test whether supervised aerobic exercise plus one pain neuroscience education session helps women aged 18–48 with migraine reduce disability and improve sensory, musculoskeletal, and psychosocial symptoms.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT06716489

• Comparing pain relief methods during medical abortion

  This study is testing whether taking pain relief medication before a medical abortion helps women feel less pain compared to taking it only when they need it.

  Recruiting Hung Vuong Hospital · Ho Chi Minh City · NCT06696573

• Comparing different doses of truncal blocks for arm surgeries

  This study is testing different amounts of local anesthesia for arm surgeries to see which dose works best for pain relief and how quickly it takes effect.

  Recruiting Gaziosmanpasa Research and Education Hospital · Istanbul · NCT06664203

• Comparing pain relief methods after neck surgery

  This study tests two different ways to block pain after neck surgery to see which one helps patients feel better and need fewer painkillers.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT06639022

• Comparing two methods for pain relief in laparoscopic bariatric surgery

  This study is testing which pain relief method works better after laparoscopic bariatric surgery for people with obesity, comparing a local anesthetic injection to a specific nerve block technique.

  Recruiting Alexandria University · Alexandria · NCT06488183

• Using local anesthesia to manage pain in facial fracture surgery

  This study is testing if using a local pain medication during facial fracture surgery can help patients recover better and use less pain relief afterward.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT06429501

• Pain management using a retroclavicular block for vascular surgery

  This study is testing a new way to manage pain during upper limb vascular surgery to see if it helps patients feel better and recover faster, especially when combined with a medication called dexamethasone.

  Recruiting New Valley University · Asyut · NCT06406712

• Pain management using a nerve block for upper limb surgery

  This study tests if a new type of nerve block can help manage pain better during upper limb surgeries and improve patient satisfaction.

  Recruiting New Valley University · Asyut · NCT06406647

• Understanding pain management after orthopedic surgery

  This study is trying to find out how much pain relief is needed after major orthopedic surgeries to help patients feel comfortable and recover better.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04811209

NIH-funded research (newest 40 of 99)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms

  A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11609950

• Building Indigenous Research Infrastructure for Substance Misuse and Pain Management

  A planned two-year effort helps the Lumbee Tribe build a community-led research infrastructure to better understand and address substance misuse and pain in their community.

  NIH research Lumbee Land Development, INC. · Pembroke, United States · NIH-11553670

• Coordinated pain care using technology in community clinics

  A large, real-world study will test a coordinated, multi-component pain care plan in community health centers to help people with chronic musculoskeletal pain get non-opioid and holistic treatments.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11473136

• Cold-triggered numbing for on-demand pain relief

  An injectable that stays inactive until the area is cooled, releasing a tiny amount of a powerful numbing drug to give on-demand local pain relief.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11468137

• Tailored opioid tapering and pain support after spine surgery for patients using opioids long-term

  A Stanford-backed plan helps people who already take opioids before spine surgery to taper safely after surgery and get non-opioid pain relief.

  NIH research Stanford University · Stanford, United States · NIH-11454729

• Gut microbiome targets to ease sickle cell pain in patients

  Researchers are studying how gut microbes affect chronic pain in people with sickle cell disease and how penicillin prophylaxis in babies might change pain pathways.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11448997

• Smartphone virtual reality to ease pain for kids during burn care at home

  A smartphone-based virtual reality tool called VR-PAT is being tested to help children feel less pain and use fewer opioid medicines when they shift from hospital care to home burn dressing changes.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11424511

• Personalized, opioid-sparing pain care for kids after major surgeries

  A multicenter effort tests and tunes a methadone-based pain protocol to reduce opioid use and side effects for children after spine fusion or heart surgery.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11404043

• Mechanomyography-based diagnostic tool for nerve function during pain procedures

  A new MMG-based diagnostic system aims to give objective, quantitative measurements of nerve function during routine preoperative pain management procedures.

  NIH research Neuralytix, LLC · Fruita, UNITED STATES · NIH-11403158

• Safe, digitally-enabled cancer pain care for patients and survivors

  A nationwide Mayo Clinic-led program tests a digitally-supported, team-based approach to managing cancer pain that may help patients and survivors receive better, safer pain care.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11400451

• Better Predicting and Personalizing Postoperative Pain Care

  Aimed at using advanced data tools to better predict and manage a patient’s pain after surgery and reduce opioid-related risks.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11398952

• Pain Management Collaboratory Coordinating Center – partner-led guidance for Veterans, military personnel, and families

  This grant provides national leadership and support to improve pain management research in veteran, military, and family care settings through pragmatic trials and practical guidelines.

  NIH research Yale University · New Haven, United States · NIH-11391370

• Actigraphy-based Monitoring to Improve Chronic Low Back Pain Care

  A patient-friendly plan to use wearable activity data to better track and manage chronic lower back pain and its impact on daily life.

  NIH research Arbor Medical Innovations, LLC · Ypsilanti, United States · NIH-11389490

• A community-led program to prevent substance misuse and improve pain care for Lumbee and other American Indian people

  This project will build a Lumbee-led research network to help prevent substance misuse and make pain care more culturally appropriate for Lumbee and nearby American Indian communities.

  NIH research Lumbee Land Development, INC. · Pembroke, United States · NIH-11369461

• Interprofessional Outpatient Therapy for Native Americans with Low Back Pain

  A collaborative outpatient program using physical and occupational therapy to help Cherokee Nation members manage low back pain without relying on drugs or surgery.

  NIH research Cherokee Nation · Tahlequah, United States · NIH-11369411

• Cold-triggered Local Anesthesia for Pain Relief

  A study testing a cold-triggered local anesthetic system designed to release pain-relief medicine when and where it’s needed, to help patients manage pain more effectively.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11364146

• Acupuncture in the Emergency Department for Pain in 5 BraveNet Centers

  A multi-center plan will try acupuncture for acute pain in adults visiting emergency departments to see if it provides better relief than usual care.

  NIH research University of California-Irvine · Irvine, United States · NIH-11359458

• Acupuncture in the Emergency Department to Ease Acute Pain in Two Patient Groups

  A multi-center study tests whether acupuncture in the ED can more effectively reduce pain quickly for adults with acute pain than usual care.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11358565

• Targeting OPRM1 exon 7 variants to reduce opioid side effects without reducing pain relief

  Aims to block certain gene variants that cause side effects from common opioid meds while keeping their pain relief.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11326813

• Better pain care for people with knee osteoarthritis and other health conditions

  This project looks at ways to make pain care more effective, affordable, and easier to access for people with knee osteoarthritis who also have other medical problems.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11325440

• Wearable long-lasting topical cooling for post-op pain relief

  A wearable, long-duration topical cooling device is being developed to help manage pain after surgery and reduce the need for opioid medicines.

  NIH research Cryo Ergonomics INC · Belmont, United States · NIH-11313074

• SmartMouth: Helping dentists use safer pain medicines after dental procedures

  A project that tests a tech-based approach to help dentists prescribe fewer opioids and use acetaminophen with NSAIDs for post-surgical dental pain, especially after wisdom tooth removals.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11299964

• Adapting a Digital Pain Coach for Young Adult Cancer Survivors

  A web-based pain management program originally designed for older adults will be adapted and tested to help young adult cancer survivors manage chronic pain.

  NIH research Northwestern University · Chicago, United States · NIH-11290556

• How State Cannabis Laws Affect Cancer Pain Care and Patient Well-being

  This project looks at how state laws about cannabis might change how people with cancer manage their pain and how they feel overall.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11260805

• Examining racial differences in pain medication prescriptions after hip and knee surgeries

  This study is looking into whether older Black Americans get less pain relief medication than White Americans after hip and knee surgeries, with the goal of finding ways to make sure everyone gets the care they need for pain management.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11249331

• Pain care for veterans with end-stage kidney disease

  This project looks at how changes in VA opioid policies have affected pain control and safety for veterans with end-stage kidney disease.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11240257

• A new inhaler for delivering anti-inflammatory medication to help manage pain in COPD patients

  This study is testing a new, easy-to-use inhaler that delivers medicine directly to the deep parts of the lungs for people with COPD, aiming to help reduce inflammation and improve comfort.

  NIH research Scientific Horizons Consulting LLC · Irvine, UNITED STATES · NIH-11237357

• Choices for Managing Chronic Pain Without Medications

  This project gives Veterans with chronic pain a decision tool and a coach to help pick and stick with non-drug pain treatments.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11225071

• Culturally tailored pain care for American Indian and Alaska Native adults in the Pacific Northwest

  This project offers a pain-management program adapted to the cultures and needs of American Indian and Alaska Native adults and will run a small randomized pilot at tribal health clinics.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11209571

• Investigating new targets to reduce side effects of pain medications without affecting pain relief

  This study is looking at how certain genetic differences can help make pain medications like fentanyl and oxycodone safer by reducing side effects and the risk of addiction, which could lead to better pain relief options for patients in the future.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11195091

• Helping veterans leaving the military get quick pain screening and follow-up care

  This project tries new ways to help veterans leaving the military get checked for pain and quickly receive brief help or referrals to treatment.

  NIH research Yale University · New Haven, United States · NIH-11193532

• Improving access to non-drug pain care for diverse Veterans

  This project will create and try out a plan to help Veterans from diverse backgrounds get guideline-based non-drug treatments for chronic pain.

  NIH research Veterans Admin Palo Alto Health Care Sys · Palo Alto, United States · NIH-11193236

• Better prediction and personalized control of pain after surgery

  This project builds computer tools to predict who will have bad pain after surgery and help doctors tailor pain control for patients recovering from operations.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11192819

• Whole Health pain-management teams to improve veterans' function and opioid safety

  This project will offer team-based Whole Health care to veterans with chronic pain to help them function better and make opioid use safer.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11190844

• Safe, comprehensive digital cancer pain care (ASCENT)

  A digital care program aims to help adults with advanced cancer get safer, more complete pain treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11187218

• Personalized opioid-sparing pain care for children after major spine or heart surgery

  This program offers personalized, methadone-centered pain plans to help children recover from spinal fusion or cardiac surgery while using fewer opioids.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11184432

• Using wearable activity monitors to improve chronic low back pain care

  This project uses wearable activity trackers to give doctors continuous information about how chronic low back pain affects daily movement for adults.

  NIH research Arbor Medical Innovations, LLC · Ypsilanti, United States · NIH-11181565

• Coordinating center to improve acute pain care

  This project helps run clinical trials aimed at finding safer, more effective ways to manage short-term (acute) pain for people recovering from injury or surgery.

  NIH research Duke University · Durham, United States · NIH-11179276

• Tech-based pain support for Asian American breast cancer survivors

  This project is building an easy-to-use web and mobile program to help Asian American breast cancer survivors with chronic pain and depression get personalized information and coaching.

  NIH research University of Texas at Austin · Austin, United States · NIH-11179187

• Understanding how doctors manage pain after childbirth

  This study looks at how doctors handle pain after childbirth, especially when it comes to using opioids, and it aims to understand if there are differences in care based on race and ethnicity, all to help make pain management better for everyone.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11178989

Related topics

Quick answers

How many Pain Management clinical trials are recruiting right now?

102, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in Turkey (Türkiye) (27 trials), United States (18 trials), China (9 trials), Egypt (7 trials), France (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 10, Phase 2: 7, Phase 4: 4, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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