Modified external oblique intercostal plane block vs erector spinae plane block for open nephrectomy
Official title: Comparison of Modified External Oblique Intercostal Plane Block and Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy: A Prospective Randomized Controlled Trial
Run by Namik Kemal University · NCT07726550 · Data updated 2026-11-12
This trial tests whether the EOIPB or ESPB provides better pain relief after open nephrectomy in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Namik Kemal University Academic / other |
| Locations | 1 site (Tekirdağ, Tekirdağ) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | February 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07726550 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with ASA I–II scheduled for elective open nephrectomy and able to consent.
✕Probably not a fit
Patients with BMI ≥35, coagulopathy, infection at the block site, or allergies to local anesthetics may not benefit from the blocks.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, assessor-blinded study at a single center comparing two ultrasound-guided fascial plane blocks for postoperative analgesia in adults undergoing elective open nephrectomy under general anesthesia. Sixty patients are randomized 1:1 to receive either ESPB or EOIPB with 30 mL of 0.25% bupivacaine after induction and before incision, in addition to standardized anesthesia and multimodal analgesia. Outcomes include postoperative pain scores, opioid use, rescue analgesia needs, and incidence of postoperative nausea and vomiting during the first 24 hours. The goal is to determine if one block offers superior analgesia and recovery compared with the other. Open nephrectomy can cause significant pain and opioid requirements; regional blocks are evaluated here as part of multimodal pain management.
Why it matters
Potential benefit: If successful, one block may provide superior pain control and reduce opioid needs after open nephrectomy.
How similar studies have gone: Prior studies support regional blocks for thoracoabdominal analgesia, but direct comparison between EOIPB and ESPB in open nephrectomy is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Scheduled for elective open nephrectomy. * Able and willing to provide written informed consent. * Willing to comply with study procedures. Exclusion Criteria: * Refusal to participate or inability to provide informed consent. * Emergency surgery. * Body mass index (BMI) greater than 35 kg/m². * Known allergy or hypersensitivity to local anesthetics. * Infection at the planned block insertion site. * Coagulopathy or ongoing anticoagulant therapy. * Pregnancy or breastfeeding. * Prisoners or other vulnerable populations unable to provide independent consent.
Where it's running
-
Tekirdağ Namık Kemal University
Tekirdağ, Tekirdağ, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Onur Baran, MD
- Email: dronurbaran@hotmail.com
- Phone: +90 539 342 25 82
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.