Ultrasound-Guided Rhomboid-Intercostal Block vs Thoracic Paravertebral Block for Pain Control After VATS
Official title: Comparison of the Ultrasound-Guided Rhomboid-Intercostal Block (RIB) Versus Thoracic Paravertebral Block (PVB) for Postoperative Analgesia in Video-Assisted Thoracoscopic Surgery (VATS): A Double-Blind Randomized Controlled Trial
Run by Blue Cross of Thessaloniki · NCT07465887 · Data updated 2026-11-12
This study tests whether the rhomboid-intercostal block (RIB) or the thoracic paravertebral block (PVB) provides better pain relief after a 3-port VATS chest surgery in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Blue Cross of Thessaloniki Academic / other |
| Locations | 1 site (Thessaloniki) |
| Status | Recruiting |
| Started | March 9, 2026 |
| Main results expected | March 2027 |
| Study ends | March 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT07465887 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-85 undergoing elective 3-port unilateral VATS, with ASA I-III, and no contraindications to regional anesthesia.
✕Probably not a fit
Patients with contraindications to local anesthetics, infection at the injection site, coagulation disorders, or obesity (BMI > 35) may not benefit from the interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, double-blind, randomized trial comparing two ultrasound-guided regional anesthesia techniques for post-operative analgesia in adults undergoing elective 3-port VATS. Participants are randomized 1:1 to receive either RIB or PVB at the T5 level with 30 ml of 0.375% ropivacaine after induction of general anesthesia. Pain will be assessed at rest and with deep breathing during the first 24 hours, and rescue analgesia protocols are in place for uncontrolled pain. Safety monitoring includes checks for hypotension, respiratory depression, and nausea, along with standard post-operative observations. The study aims to determine which block provides superior analgesia with a standardized post-operative regimen.
Why it matters
Potential benefit: If successful, this trial could identify a more effective regional anesthesia technique to reduce post-operative pain after VATS.
How similar studies have gone: Past studies have explored regional blocks for thoracic surgery, with mixed results; this trial adds a direct comparison under ultrasound guidance for VATS analgesia.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (18-85 years old), * ASA physical status I-III * scheduled for elective 3-port unilateral VATS. Exclusion Criteria: * Allergy to local anesthetics * infection at the injection site * coagulation disorders * severe neurological disorder * obesity (BMI \> 35) * opioid addiction * conversion to open thoracotomy, admission to ICU. * renal disease, high serum Creatinine levels
Where it's running
-
Blue Cross Thessaloniki
Thessaloniki, Greece Recruiting
Study contacts
- Study coordinator: Dimitra Katholiki Papazoglou
- Email: dimitapaz22@gmail.com
- Phone: 00306983150795
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.