PECS-II versus ESP nerve blocks for pain control during breast surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult female patients scheduled for elective unilateral or bilateral breast surgery receive either a PECS-II block or an erector spinae plane (ESP) block before anesthesia. Intraoperative opioid dosing is guided in real time by the Nociception Level Index (NOL) monitor to tailor analgesia. The primary focus is intraoperative opioid consumption, with attention to downstream outcomes such as postoperative pain and opioid-related side effects. The trial directly compares the two regional techniques to see which provides greater opioid-sparing when combined with NOL-guided anesthesia.

Why it matters

Who can join: the full rules

Eligibility Criteria This study involves adult female patients undergoing elective breast surgery for benign or malignant conditions. The goal is to evaluate the effectiveness of regional anesthesia techniques (PECS-II and ESP blocks) in reducing intraoperative opioid consumption, guided by Nociception Level Index (NOL) monitoring.

Inclusion Criteria:

Female patients aged 18 to 80 years ASA Physical Status Classification I-III

Scheduled for elective unilateral or bilateral breast surgery, including one or more of the following:

Lumpectomy with axillary lymph node biopsy or dissection Breast reconstruction Breast reduction Mastopexy Implant expander removal or placement

Exclusion Criteria:

Morbid obesity (BMI \> 40 kg/m²) Presence of non-sinus cardiac rhythm Chronic opioid use (defined as daily use for \>2 weeks in the last month or total use \>4 weeks) History of opioid abuse or dependence Comorbidities causing moderate to severe functional limitation Inability to communicate with study personnel or follow instructions Pregnancy or breastfeeding Known allergy or hypersensitivity to bupivacaine or any study-related medication

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Where it's running

• Koc University
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ilayda Kalyoncu Karahan, MD
• Email: ilaydaakalyoncu@gmail.com
• Phone: +905325105014

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.