ESP vs RISS blocks for pain after gallbladder removal
Official title: Comparison of the Analgesic Efficacy and Effects on Diaphragmatic Function of Bilateral Erector Spinae Plane Block and Bilateral Rhomboid Intercostal-Subserratus Plane Block in Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial
Run by Bursa Yuksek Ihtisas Training and Research Hospital · NCT07655323 · Data updated 2026-11-12
This study tests whether bilateral erector spinae plane (ESP) blocks or bilateral rhomboid intercostal-subserratus plane (RISS) blocks provide better pain relief after laparoscopic cholecystectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Bursa Yuksek Ihtisas Training and Research Hospital Government |
| Locations | 1 site (Bursa, Nilüfer) |
| Status | Recruiting |
| Started | June 18, 2026 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT07655323 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–75 undergoing elective laparoscopic cholecystectomy under general anesthesia with no contraindications to regional anesthesia.
✕Probably not a fit
Patients with contraindications to nerve blocks, urinary or systemic contraindications, or those in whom a block fails may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective randomized trial compares two ultrasound-guided regional anesthesia techniques, ESP and RISS blocks, in adults undergoing elective laparoscopic cholecystectomy. The goal is to see which block offers better postoperative pain relief and preserves diaphragmatic function, while also looking at opioid use, lung function, and recovery outcomes. Participants are adults aged 18 to 75 with ASA I–III, and the study assesses pain at rest and with movement, respiratory parameters, rescue analgesia, and adverse events. Primary outcomes focus on analgesic efficacy and diaphragmatic function; secondary outcomes include opioid consumption, pain scores, pulmonary measures, and safety events.
Why it matters
Potential benefit: If successful, the preferred block could reduce pain and opioid needs while supporting better respiratory recovery after surgery.
How similar studies have gone: Regional fascial plane blocks have shown analgesic benefits in abdominal surgery, though direct head-to-head comparison of ESP and RISS in this setting is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:- * Age between 18 and 75 years * ASA physical status I-III * Scheduled for elective laparoscopic cholecystectomy under general anesthesia * Provision of written informed consent Exclusion Criteria: * Coagulation disorders or anticoagulant therapy * Known allergy to local anesthetics * Infection at the block application site * Pregnancy or lactation * Chronic opioid use * Cognitive impairment * Refusal to participate in the study * Technical inability to perform the block * Failed block
Where it's running
-
Bursa City Hospital
Bursa, Nilüfer, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Mürsel Ekinci, MD — Bursa City Hospital, Health Sciences University Bursa Faculty of Medicine
- Study coordinator: Mürsel Ekinci, MD
- Email: drmurselekinci@gmail.com
- Phone: +905067137596
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.