What affects pain after taking gum grafts from the palate?
Patient-Related Factors Influencing Postoperative Pain After Gingival Graft Harvesting From the Palate: A Prospective Study
This project will see if patient, psychological, and clinical factors predict how much pain adults experience after having gum grafts taken from the palate.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 93 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitat Internacional de Catalunya Academic / other |
| Locations | 1 site (Barcelona, Sant Cugat Del Valles) |
| Trial ID | NCT07377370 on ClinicalTrials.gov |
What this trial studies
This prospective cohort at the Clínica Universitària d'Odontologia of Universitat Internacional de Catalunya in Barcelona will enroll consecutive adults who need mucogingival surgery for root coverage or soft tissue augmentation. All participants will receive standardized pre‑surgical periodontal care and oral hygiene instruction, and gingival grafts will be harvested from the palate under local anesthesia using a uniform surgical technique with standardized postoperative analgesics and care. Validated questionnaires will collect anticipated and postoperative pain scores plus measures of stress, dental anxiety, psychological profile, and personality traits alongside clinical healing measures. The study excludes patients with conditions or medications that impair healing or pain perception to focus on patient‑related predictors of postoperative pain.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy adults (18 years or older) who need mucogingival surgery for root coverage or soft tissue augmentation and have good periodontal health with full‑mouth plaque and bleeding scores ≤20%.
Not a fit: Patients with systemic or metabolic diseases that impair healing, heavy smokers, chronic pain disorders, psychiatric diagnoses, recent grafting, pregnancy or lactation, or regular use of interfering medications are excluded and are unlikely to benefit from this protocol's findings.
Why it matters
Potential benefit: If successful, the results could help clinicians identify patients at higher risk of intense postoperative pain and tailor pain control and counseling after palatal graft harvesting.
How similar studies have performed: Previous observational studies have identified some clinical and psychological predictors of pain after dental surgery, but prospective, comprehensive data specifically for palatal gingival graft harvesting are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients requiring mucogingival surgery for gingival augmentation or root coverage purposes * Systemically healthy individuals aged 18 years or older * Healthy periodontal status according to the AAP/EFP definition * Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) ≤ 20% Exclusion Criteria: * Pregnancy or lactation * Self-reported smoking ≥10 cigarettes/day * Presence of metabolic or systemic diseases that negatively affect soft tissue healing * Use of medications that may interfere with wound healing * Chronic pain disorders (e.g., fibromyalgia) * Psychiatric diagnoses * Regular use of analgesics, antidepressants, anxiolytics, or opioids * Allergy to the study medication (Ibuprofen) * History of grafting within the past 6 months * Ongoing orthodontic therapy
Where this trial is running
Barcelona, Sant Cugat Del Valles
- Clínica Universitària d'Odontologia - UIC Barcelona — Barcelona, Sant Cugat Del Valles, Spain (Recruiting)
Study contacts
- Study coordinator: Lory Abrahamian, DDS, MSc, PhD Candidate
- Email: lory.abrahamian@uic.es
- Phone: +34722528012
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.