Impact of genetics on pain relief from NSAIDs before dental procedures
The Effect of Genetic Polymorphisms on the Response to Preoperative Non-Steroidal Anti-Inflammatory Drugs in the Management of Endodontic Postoperative Pain
This study tests how genetic differences affect the pain relief people feel from common pain medications before getting a root canal.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ataturk University Academic / other |
| Locations | 1 site (Erzurum, Erzurum) |
| Trial ID | NCT06937853 on ClinicalTrials.gov |
What this trial studies
This study evaluates how genetic variations affect the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain after endodontic treatment. Participants will receive standard doses of NSAIDs before undergoing root canal therapy, and their pain responses will be monitored. Genetic analysis will be conducted to explore the relationship between individual gene variations and pain relief outcomes. The goal is to enhance personalized pain management strategies in dentistry.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with symptomatic apical periodontitis in vital mandibular molars.
Not a fit: Patients with severe systemic diseases, psychiatric disorders, or those who have recently used analgesics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective pain management tailored to individual genetic profiles in dental procedures.
How similar studies have performed: While the specific genetic approach in this context may be novel, similar studies have shown promise in personalizing pain management based on genetic factors.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged between 18 and 65 years 2. Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis 3. ASA physical status classification I or II 4. Preoperative VAS pain score greater than 50 5. No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain) Exclusion Criteria: 1. Patients classified as ASA III or higher 2. Pregnant women or those suspected of being pregnant 3. Presence of root canal curvature greater than 25° (Schilder classification) 4. Patients with generalized periodontitis 5. Presence of periodontal pockets deeper than 3 mm in the affected tooth 6. History of systemic disease or known allergies 7. Patients with diagnosed psychiatric or psychological disorders 8. Presence of swelling, sinus tract, or preoperative tenderness on palpation 9. Patients with bruxism 10. Presence of resorption in the affected tooth 11. Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure 12. Teeth with root fractures, ankylosis, or pathological mobility
Where this trial is running
Erzurum, Erzurum
- Ataturk University, Faculty of Dentistry, Department of Endodontics — Erzurum, Erzurum, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Ertugrul Karatas, Prof. Dr. — Ataturk University, Faculty of Dentistry, Department of Endodontics
- Study coordinator: Ertugrul Karatas, Prof. Dr.
- Email: dtertu@windowslive.com
- Phone: +905337080730
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.