Preventive Analgesia With Anrikefon in Laparoscopic Gallbladder Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, double-blind, randomized trial compares two timing strategies of Anrikefon administration for preventive analgesia in adults undergoing laparoscopic cholecystectomy. Participants are randomly assigned to preventive analgesia or bridging analgesia in a 1:1 ratio. The primary endpoint is the time-weighted sum of pain intensity differences over the first 24 hours after surgery, measured by NRS at multiple post-op time points. The study aims to clarify timing for optimal pain control while monitoring recovery quality. Safety and tolerability of Anrikefon with limited central effects are also assessed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ASA physical status classification I-III;
2. Age 18-65 years;
3. Scheduled for elective laparoscopic cholecystectomy;
4. Voluntary signed informed consent;
5. BMI between 18-28 kg/m²;
6. No history of general anesthesia surgery within the past 3 months.

Exclusion Criteria:

1. Severe cardiovascular disease, respiratory disease, or psychiatric disorders;
2. Severe renal insufficiency;
3. Recent use of diuretics or compound medications containing diuretics;
4. Continuous use of opioid analgesics for more than 10 days within the past 3 months;
5. Use of medications with unknown half-life affecting analgesic efficacy within 14 days prior to randomization;
6. Pregnant women, lactating women, or those planning pregnancy in the near future;
7. History of hypersensitivity to study medications.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Wei Xiao — Xuanwu Hospital, Beijing
• Study coordinator: Wei Xiao, PhD
• Email: kitten15@126.com
• Phone: +8613810971299

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.