Comparing drainage options after minimally invasive esophagectomy
Official title: Comparison of the Application Effects of Different Drainage Modes in the Perioperative Period of Minimally Invasive Three-Field Radical Esophagectomy for Esophageal Cancer
Run by Ruijin Hospital · NCT07004634 · Data updated 2026-11-12
This trial tests three different drainage approaches after minimally invasive esophagectomy to see which leads to less postoperative pain and fewer complications for adults with esophageal cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | April 30, 2025 |
| Main results expected | May 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | June 10, 2025 |
| Trial ID | NCT07004634 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with pathologically confirmed esophageal cancer scheduled for three‑incision minimally invasive esophagectomy who are ASA class I–III and do not have chronic preoperative pain or major cardiopulmonary or coagulation contraindications are ideal candidates.
✕Probably not a fit
Patients with chronic pain or long‑term analgesic use, severe cardiopulmonary dysfunction (e.g., FEV1 <50%), coagulation disorders, need for reoperation, extensive pleural adhesions, or combined organ resections are excluded and therefore unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares three postoperative drainage strategies following three‑incision minimally invasive esophagectomy: a chest mediastinal tube, an abdominal mediastinal tube, and a combination of chest tube plus chest mediastinal tube. Adult patients (age ≥18) with pathologically confirmed esophageal cancer and ASA class I–III who are undergoing the specified procedure are eligible, while those with chronic pain, severe cardiopulmonary dysfunction, coagulation disorders, reoperation, or extensive intraoperative adhesions are excluded. The trial measures perioperative outcomes with emphasis on postoperative pain and complication profiles to address current evidence gaps. All procedures and follow-up occur at a single center (Ruijin Hospital, Shanghai).
Why it matters
Potential benefit: If successful, the results could identify a drainage approach that reduces postoperative pain and complications and guide standard practice after minimally invasive esophagectomy.
How similar studies have gone: Previous studies of mediastinal versus pleural drainage after esophagectomy have shown mixed results, and direct randomized comparisons of these three specific drainage strategies are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Pathologically confirmed esophageal cancer requiring three-incision esophagectomy (cervical, thoracic, and abdominal incisions) * ASA physical status class I-III Exclusion Criteria: * History of chronic pain or long-term use of analgesics prior to surgery * Severe cardiopulmonary dysfunction (e.g., FEV1 \<50%) * Coagulation disorders or patients undergoing reoperation * Intraoperative findings of extensive pleural adhesions, combined resection of adjacent organs, or other conditions deemed by the investigator to warrant exclusion
Where it's running
-
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Hecheng Li, PhD, MD — Ruijin Hospital
- Study coordinator: Hecheng Li, PhD, MD
- Email: lihecheng2000@hotmail.com
- Phone: 00862164370045
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
PECS II vs SPSIP nerve blocks for pain after mastectomy
This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.
-
Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft
This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.
-
Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy
This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.
-
Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy
This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.
-
PF-08098488 in adults with advanced solid tumors
This study tests PF-08098488 in adults whose cancer has progressed or returned after prior treatment.
-
Natural Biopolymer-Based Irrigant for Root Canal Cleaning
This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.