Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 50 Women only

Comparing dexmedetomidine plus ketamine doses for C-section pain

Official title: Comparison of Different Doses of Dexmedetomidine in Combination With Ketamine for Control of Post-Operative Pain in Lower Segment Caesarean Section Surgeries

Run by Fatima Memorial Hospital · NCT07022821 · Data updated 2026-11-12

This study will test three doses of dexmedetomidine given with a fixed ketamine dose to see which combination best controls pain after an elective cesarean section with the fewest side effects.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 50 Years
SexWomen only
Enrollment90 (estimated)
SponsorFatima Memorial Hospital
Academic / other
Locations1 site (Lahore, Punjab Province)
StatusRecruiting
StartedMay 16, 2025
Main results expectedAugust 16, 2025
Study endsAugust 31, 2025
Registry record updatedJune 18, 2025
Trial IDNCT07022821 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adult women scheduled for elective lower-segment cesarean section under spinal anesthesia who are ASA Physical Status II and can give informed consent are ideal candidates.

Probably not a fit

Patients undergoing emergency cesarean, those with significant medical comorbidities, known allergies to the study drugs, or documented psychiatric illness would not be eligible and are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 4 interventional study compares three different dexmedetomidine dose regimens combined with a fixed ketamine dose as adjuvants during spinal anesthesia for elective lower-segment cesarean section. Eligible participants will receive one of the dexmedetomidine dose combinations and be monitored for postoperative pain scores, opioid consumption, and adverse events. The trial aims to identify the dose pairing that provides the strongest pain relief with the lowest rate of side effects. Patients with significant comorbidities, emergency surgery, known drug allergies, or documented psychiatric illness are excluded.

Why it matters

Potential benefit: If successful, the regimen could provide better post-cesarean pain relief with reduced opioid use and fewer opioid-related side effects.

How similar studies have gone: Prior smaller trials and meta-analyses have shown that dexmedetomidine or ketamine as anesthetic adjuvants can reduce postoperative pain and opioid needs, but the optimal combined dosing strategy remains less well established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Elective lower segment cesarean section
* American Society of Anesthesiologists (ASA) Physical Status II
* Provided informed consent

Exclusion Criteria:

* Known drug allergy
* Presence of significant comorbidities
* Emergency surgery
* Documented psychiatric illness

Where it's running

  • Department of Anesthesiology, Fatima Memorial Hospital
    Lahore, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.