Comparing dexmedetomidine plus ketamine doses for C-section pain
Comparison of Different Doses of Dexmedetomidine in Combination With Ketamine for Control of Post-Operative Pain in Lower Segment Caesarean Section Surgeries
PHASE4 · Fatima Memorial Hospital · NCT07022821
This study will test three doses of dexmedetomidine given with a fixed ketamine dose to see which combination best controls pain after an elective cesarean section with the fewest side effects.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | Fatima Memorial Hospital (other) |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT07022821 on ClinicalTrials.gov |
What this trial studies
This phase 4 interventional study compares three different dexmedetomidine dose regimens combined with a fixed ketamine dose as adjuvants during spinal anesthesia for elective lower-segment cesarean section. Eligible participants will receive one of the dexmedetomidine dose combinations and be monitored for postoperative pain scores, opioid consumption, and adverse events. The trial aims to identify the dose pairing that provides the strongest pain relief with the lowest rate of side effects. Patients with significant comorbidities, emergency surgery, known drug allergies, or documented psychiatric illness are excluded.
Who should consider this trial
Good fit: Adult women scheduled for elective lower-segment cesarean section under spinal anesthesia who are ASA Physical Status II and can give informed consent are ideal candidates.
Not a fit: Patients undergoing emergency cesarean, those with significant medical comorbidities, known allergies to the study drugs, or documented psychiatric illness would not be eligible and are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the regimen could provide better post-cesarean pain relief with reduced opioid use and fewer opioid-related side effects.
How similar studies have performed: Prior smaller trials and meta-analyses have shown that dexmedetomidine or ketamine as anesthetic adjuvants can reduce postoperative pain and opioid needs, but the optimal combined dosing strategy remains less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective lower segment cesarean section * American Society of Anesthesiologists (ASA) Physical Status II * Provided informed consent Exclusion Criteria: * Known drug allergy * Presence of significant comorbidities * Emergency surgery * Documented psychiatric illness
Where this trial is running
Lahore, Punjab Province
- Department of Anesthesiology, Fatima Memorial Hospital — Lahore, Punjab Province, Pakistan (RECRUITING)
Study contacts
- Study coordinator: Ahmed Naeem, MBBS
- Email: 2505.ahmed@gmail.com
- Phone: +923114681512
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Postoperative Pain, Cesarean Section Pain, Cesarean Pain, Multimodal Analgesia, Spinal Anesthesia, Dexmedetomidine, Ketamine, Postoperative pain