Comparing dexmedetomidine plus ketamine doses for C-section pain
Official title: Comparison of Different Doses of Dexmedetomidine in Combination With Ketamine for Control of Post-Operative Pain in Lower Segment Caesarean Section Surgeries
Run by Fatima Memorial Hospital · NCT07022821 · Data updated 2026-11-12
This study will test three doses of dexmedetomidine given with a fixed ketamine dose to see which combination best controls pain after an elective cesarean section with the fewest side effects.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | Fatima Memorial Hospital Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | May 16, 2025 |
| Main results expected | August 16, 2025 |
| Study ends | August 31, 2025 |
| Registry record updated | June 18, 2025 |
| Trial ID | NCT07022821 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult women scheduled for elective lower-segment cesarean section under spinal anesthesia who are ASA Physical Status II and can give informed consent are ideal candidates.
✕Probably not a fit
Patients undergoing emergency cesarean, those with significant medical comorbidities, known allergies to the study drugs, or documented psychiatric illness would not be eligible and are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase 4 interventional study compares three different dexmedetomidine dose regimens combined with a fixed ketamine dose as adjuvants during spinal anesthesia for elective lower-segment cesarean section. Eligible participants will receive one of the dexmedetomidine dose combinations and be monitored for postoperative pain scores, opioid consumption, and adverse events. The trial aims to identify the dose pairing that provides the strongest pain relief with the lowest rate of side effects. Patients with significant comorbidities, emergency surgery, known drug allergies, or documented psychiatric illness are excluded.
Why it matters
Potential benefit: If successful, the regimen could provide better post-cesarean pain relief with reduced opioid use and fewer opioid-related side effects.
How similar studies have gone: Prior smaller trials and meta-analyses have shown that dexmedetomidine or ketamine as anesthetic adjuvants can reduce postoperative pain and opioid needs, but the optimal combined dosing strategy remains less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective lower segment cesarean section * American Society of Anesthesiologists (ASA) Physical Status II * Provided informed consent Exclusion Criteria: * Known drug allergy * Presence of significant comorbidities * Emergency surgery * Documented psychiatric illness
Where it's running
-
Department of Anesthesiology, Fatima Memorial Hospital
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Ahmed Naeem, MBBS
- Email: 2505.ahmed@gmail.com
- Phone: +923114681512
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.