QL Block vs EO Plane Block for Pain After Open Kidney Removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective randomized trial in adults undergoing open nephrectomy at Cairo University. Participants will be randomly assigned to receive either a transmuscular quadratus lumborum block or an external oblique plane block under ultrasound guidance, in addition to standard general anesthesia and multimodal pain control. The primary outcome is total intravenous morphine consumption in the first 24 hours postoperatively. Both blocks are performed prior to incision by an experienced anesthesiologist, with bupivacaine used as the local anesthetic. The study aims to determine which regional technique offers superior analgesia for this major abdominal surgery.

Why it matters

Who can join: the full rules

\*\*Inclusion Criteria:\*\*

* Adult patients aged 18 to 65 years.
* Patients undergoing open nephrectomy at the National Cancer Institute, Cairo University.
* American Society of Anesthesiologists (ASA) physical status II-III.
* Body mass index (BMI) greater than 20 kg/m² and less than 35 kg/m².

\*\*Exclusion Criteria:\*\*

* Patient refusal to participate.
* ASA physical status IV.
* Age less than 18 years or greater than 65 years.
* BMI less than 20 kg/m² or greater than 35 kg/m².
* Known allergy or contraindication to any study medication, including local anesthetics or opioids.
* History of psychiatric disorders or chronic pain.
* Contraindications to regional anesthesia, including local infection at the injection site, pre-existing neuropathy, or coagulopathy.
* Severe organ dysfunction, including cardiac dysfunction (ejection fraction \<40%), respiratory dysfunction (FEV1 \<50% of predicted or requirement for home oxygen therapy), hepatic dysfunction (Child-Pugh class C), or renal dysfunction (estimated glomerular filtration rate \<30 mL/min/1.73 m²).

Where it's running

• Cairo University
  Cairo, Egypt Recruiting
• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Mona H Abdelhamid, MD — Professor of anesthesia
• Study coordinator: Sayed M Abed, MD
• Email: sayed.abed@nci.cu.edu.eg
• Phone: 002-01226806532

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.