Deep rectus sheath block to reduce pain after laparoscopic gallbladder removal
Official title: Deep Rectus Sheath Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
Run by Istinye University · NCT06976320 · Data updated 2026-11-12
This trial will test whether adding a deep rectus sheath nerve block can reduce pain and opioid use after laparoscopic gallbladder removal in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Istinye University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | September 9, 2025 |
| Main results expected | December 2025 |
| Study ends | January 2026 |
| Registry record updated | September 22, 2025 |
| Trial ID | NCT06976320 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with ASA physical status I–II who are scheduled for elective laparoscopic cholecystectomy and do not have contraindications to regional anesthesia are ideal candidates.
✕Probably not a fit
Patients with allergy to local anesthetics, coagulopathy, infection at the block site, advanced hepatic or renal failure, chronic pain syndromes, substance abuse, severe cardiopulmonary disease, or significant psychiatric disorders are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for elective laparoscopic cholecystectomy are assigned to either standard postoperative care with morphine patient-controlled analgesia (PCA) or to receive a deep rectus sheath block at the end of surgery plus the same morphine PCA. The study records total morphine consumption in the first 24 postoperative hours, numerical rating scale pain scores, use of rescue analgesics, and incidence of postoperative nausea and vomiting. The deep rectus sheath block is a modified version of the conventional rectus sheath block and has been reported only in a few case reports for this operation. The trial compares analgesic outcomes between the two groups to see if the block lowers opioid needs and pain after surgery.
Why it matters
Potential benefit: If successful, the block could lower opioid consumption and reduce postoperative pain and nausea after laparoscopic gallbladder removal.
How similar studies have gone: Other regional approaches such as transversus abdominis plane and erector spinae plane blocks have shown benefit for abdominal surgery, but the deep rectus sheath block is relatively novel and reported only in a few case reports to date.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 80 years * Patients with American Society of Anesthesiology (ASA) physical status I-II * Patients scheduled for a laparoscopic cholecystectomy Exclusion Criteria: * Allergy to local anesthetics * Coagulopathy * Skin infection at the deep rectus sheath block area * Advanced hepatic or renal failure * Chronic pain syndromes * Alcohol or drug abuse * Severe pulmonary and/or cardiovascular disease * Psychiatric disorders
Where it's running
-
Istinye University Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Taylan Sahin, M.D. — Istinye University
- Study coordinator: Taylan Sahin, M.D.
- Email: taylansah@hotmail.com
- Phone: +902129794000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.