Dexmedetomidine added to a nerve block for middle ear surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, controlled Phase 2 trial comparing two nerve block regimens given under ultrasound guidance before anesthesia induction. One group receives bupivacaine alone, the other receives bupivacaine plus dexmedetomidine, with all patients receiving standard general anesthesia and a uniform rescue analgesia plan. Outcomes tracked include duration of analgesia, pain scores, opioid consumption, emergence agitation, hemodynamics, and adverse effects over 24 hours postoperatively. The study uses computer-generated randomization and sealed envelopes, with outcome assessors blinded to group allocation. Forty adults with ASA I-II undergoing elective middle ear surgery are enrolled.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion Criteria:
* Patients scheduled for elective middle ear surgery under general anesthesia
* Aged 18-70 years
* ASA physical status I or II
* BMI ≤ 35 kg/m2

Exclusion Criteria:

* Patient refusal
* Known allergy to local anesthetics or dexmedetomidine
* Coagulation disorders or anticoagulant therapy
* Infection at the injection site
* History of head and neck surgery
* Significant cardiovascular disease (heart block, severe bradycardia, or uncontrolled hypertension)
* Hepatic or renal impairment
* Chronic opioid or analgesic use
* Psychiatric disorders or inability to cooperate
* Pregnancy or lactation

Where it's running

• Minia university hospital
  Minya, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.