Condition

Analgesia clinical trials and research

• 57Clinical trials
• 42NIH research projects
• 1New in 30 days
• 21Countries

Newest Analgesia clinical trials

All recruiting trials (57)

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Esmolol vs Dexmedetomidine for opioid-sparing in laparoscopic gynecologic surgery

  This study tests whether low-dose esmolol or dexmedetomidine, given during surgery, reduces opioid use and improves pain control after laparoscopic hysterectomy compared with placebo.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT07846722

• Three nerve blocks for knee replacement: which one works best

  This trial tests three different nerve blocks used during knee replacement to see which provides the best pain relief for patients after surgery.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Italy and 1 other locations · NCT07751653

• Rectointercostal plane block to reduce pain after laparoscopic gallbladder removal

  This study tests whether giving a rectointercostal block during laparoscopic cholecystectomy can lower postoperative pain for patients without changing general anesthesia.

  Recruiting Istinye University · Istanbul · NCT07745972

• STIL block versus RIB with sub-serratus plane block for pain relief after pediatric chest surgery

  This study tests whether the STIL plane block provides comparable or better pain relief than the combination of RIB and sub-serratus plane block in children after thoracotomy.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07666334

• SPSIP Block to Help Pain After Breast Reduction Surgery

  A randomized trial tests whether adding an ultrasound-guided SPSIP block can lower opioid use in the first 24 hours after bilateral breast reduction surgery.

  Recruiting Cumhuriyet University Hospital · Sivas, Sivas · NCT07657949

• Perineural Catheter for Hindfoot Surgery Pain Control

  This study tests whether a continuous perineural catheter delivering local anesthetic after hindfoot surgery helps with pain more than standard care.

  Recruiting University Hospital, Angers · Angers · NCT07638514

• Analgesia after total hip replacement using SA-QLB vs PENG block

  This study tests whether the SA-QLB or the PENG block provides better pain relief for adults having a total hip replacement.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07606794

• Pain relief for high-risk children after anorectal and penile surgery using a targeted nerve block

  This study tests whether ultrasound-guided sacral multifidus plane blocks can provide safe, effective pain relief for high-risk pediatric patients undergoing anorectal and penile surgeries.

  Recruiting Zagazig University · Zagazig · NCT07602894

• Opioid-free versus opioid-based anesthesia for children having cleft lip or palate repair

  This will test whether opioid-free anesthesia can control pain and reduce emergence agitation in children undergoing cleft lip or palate repairs.

  Recruiting University of Zagreb · Zagreb · NCT07557576

• Scalp nerve blocks plus dexmedetomidine to reduce opioids after brain tumor surgery

  This trial tests whether scalp nerve blocks and/or dexmedetomidine can reduce opioid needs and help prevent delirium after supratentorial brain tumor surgery.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07441421

• Intrathecal versus epidural morphine for pain after cesarean delivery

  This test will compare a single intrathecal morphine shot versus epidural morphine for controlling pain in women having elective cesarean delivery.

  Recruiting Phase 4 Hospital Central do Funchal · Funchal, Madeira · NCT07386353

• One preoperative dose of paracetamol or ibuprofen to reduce opioids during and after septorhinoplasty

  This project will test whether giving one dose of paracetamol or ibuprofen before septorhinoplasty cuts down opioid use during and after surgery.

  Recruiting Samsun University · Samsun · NCT07337629

• Single-dose IV magnesium sulfate to reduce pain after laparoscopic gallbladder removal

  We will try a single IV dose of magnesium sulfate to see if adults having elective laparoscopic gallbladder removal need less morphine after surgery.

  Recruiting at 2 sites Phase 4 Tata Main Hospital · Jamshedpur, Jharkhand and 1 other locations · NCT07328893

• Sedation and pain control for adults with fractures and dislocations in the emergency department

  This project will try different sedation and pain-control methods to see which gives adults the best pain relief and satisfaction during emergency-room reductions of fractures or dislocations.

  Recruiting at 3 sites Region Zealand · Holbæk, Region Sjælland and 2 other locations · NCT07314450

• Using a number-based pain score plus a simple activity score to guide rescue pain medicine after surgery

  This project will test whether using a combined numerical pain score and a simple Functional Activity Score to decide when to give rescue pain medicine helps adults recover after surgery.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo · NCT07310953

• IV pain medicine, thoracic epidural, and erector spinae plane block for long-term pain after open-heart surgery

  This study will compare three common pain-control approaches—IV pain medicines, thoracic epidural, and erector spinae plane block—to see if one lowers chronic pain three months after open-heart surgery.

  Recruiting Karadeniz Technical University · Trabzon, Trabzon · NCT07257744

• Perioperative high-dose nicotine patch for pain sensitivity in male smokers undergoing thoracic surgery

  We will try a high-dose nicotine patch around the time of surgery to see if it reduces pain sensitivity in adult male smokers having thoracoscopic lung surgery.

  Recruiting Henan Provincial People's Hospital · Zhengzhou, Henan · NCT07250230

• Adding an anterior capsular block to a steroid injection for frozen shoulder pain

  This test will see if adding an anterior capsular block to an intraarticular steroid injection gives better and longer pain relief for people aged 41–65 with adhesive capsulitis.

  Recruiting Zagazig University · Zagazig · NCT07235982

• NeuroCuple for pain after cesarean delivery

  This study will test whether the NeuroCuple non-drug wearable device can reduce pain and opioid use in women having cesarean delivery.

  Recruiting Inova Health Care Services · Falls Church, Virginia · NCT07185425

• Comparing shoulder nerve blocks to see effects on diaphragm movement and pain after arthroscopic shoulder surgery

  We will see if three types of ultrasound-guided nerve blocks (interscalene, suprascapular, and anterior glenoid) reduce pain and change diaphragmatic movement in adults having elective arthroscopic shoulder surgery.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07090733

• Continuous erector spinae versus edge of laminar block for pain relief and breathing after multiple rib fractures

  This will test whether a continuous erector spinae block or a continuous edge of laminar block provides better pain relief and preserves diaphragmatic movement in adults with unilateral multiple rib fractures.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07069101

• Dual-chamber patient-controlled pain relief after laparoscopic sleeve gastrectomy

  This test checks whether a dual-chamber IV patient-controlled pump delivering fentanyl plus ketorolac reduces pain and postoperative nausea and vomiting in adults having laparoscopic sleeve gastrectomy.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyunggi-do · NCT07051109

• Co-designed pain and sedation protocol for adults on ECMO

  This project will test a co-designed pain and sedation plan to see if it's acceptable for adults receiving ECMO and similar ventilated ICU patients.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT07032987

• Comparing two methods for pain relief after minimally invasive heart surgery

  This study is testing two different ways to relieve pain after minimally invasive heart surgery to see which one helps patients feel better and use fewer pain medications.

  Recruiting İstanbul Yeni Yüzyıl Üniversitesi · Istanbul · NCT06968065

• Adductor canal plus IPACK block versus adductor canal block alone for pain control after HTO/DFO/TTO

  This study tests whether adding an IPACK block to an adductor canal block reduces postoperative pain and opioid use in adults having high tibial, distal femoral, or tibial tubercle osteotomy.

  Recruiting Phase 4 NYU Langone Health · New York, New York · NCT06952556

• Ultrasound-guided auricularis magnus nerve block to reduce pain after middle ear surgery

  This study will test whether an ultrasound-guided auricularis magnus nerve block reduces postoperative pain and bleeding in adults having middle ear surgery.

  Recruiting Kocaeli University · Istanbul · NCT06869967

• Combining two methods for pain relief after knee surgery

  This study is testing if using a combination of a nerve block and a medication can help people feel less pain after knee surgery.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT06837844

• Comparing two types of nerve blocks for pain relief after knee surgery

  This study is testing which of two types of nerve blocks helps adults feel less pain and recover better after knee surgery.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT06809842

• Survey on Parents' Understanding of Pediatric Sedation

  This study is trying to understand what parents know and feel about sedation for their kids during medical procedures to improve communication and support from healthcare providers.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Italy · NCT06794879

• Blocking nerves during gallbladder surgery to reduce pain and nausea

  This study is testing if using a combination of a long-lasting pain medicine and a steroid during gallbladder surgery can help reduce pain and nausea for patients after the operation.

  Recruiting at 2 sites Phase 4 Universidad Simón Bolívar · Barranquilla, Atlantivo and 1 other locations · NCT06753500

• Ultrasound-guided pain relief for heart procedures

  This study is testing if using ultrasound to guide a specific pain relief technique can make heart procedures more comfortable for patients.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06576128

• Using Exparel to control pain after MPFL reconstruction in kids

  This study sees if adding Exparel to standard local anesthesia reduces post-op pain and opioid pill use in patients aged 13 and older having an isolated MPFL reconstruction.

  Recruiting Phase 2 Texas Scottish Rite Hospital for Children · Frisco, Texas · NCT06559215

• Using Vitamin B Complex for Pain Relief After Cesarean Section

  This study is testing if adding vitamin B complex to standard pain relief methods can help women recover better after a cesarean section while reducing the need for opioids.

  Recruiting Ain Shams University · Cairo, Egypt · NCT06446830

• ESPB versus PIFB for pain control after open-heart (sternotomy) surgery

  We will test whether an erector spinae plane block (ESPB) or a pecto‑intercostal fascial plane block (PIFB) gives better pain relief and recovery for adults having their first open‑heart (sternotomy) surgery.

  Recruiting Taichung Veterans General Hospital · Taichung, Taiwan · NCT06322810

• Comparing nerve block and morphine for pain relief after hip surgery

  This study tests whether a nerve block can provide the same pain relief as morphine for people recovering from hip surgery.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT06317870

• Nebulized Fentanyl for Pain Relief in Healthy Adults

  This study tests if using a nebulizer to deliver fentanyl can safely and comfortably relieve pain in healthy adults without needing needles.

  Recruiting Phase 1 University Hospital, Rouen · Rouen, France · NCT06281951

• Using Manuka honey to relieve pain after tonsil surgery

  This study is testing if Manuka honey can help adults feel less pain after tonsil surgery compared to a placebo while they also receive standard pain relief.

  Recruiting East and North Hertfordshire NHS Trust · Stevenage · NCT06275698

• Using TENS units to reduce pain during IUD insertion

  This study is testing if using TENS units can help reduce pain for women aged 12 to 50 during IUD insertion.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT06240260

• Comparing high and low dose pain relief methods after heart valve surgery

  This study is testing whether a high or low dose of a new pain relief method can help patients after heart valve surgery feel less pain and use fewer opioids.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT06205875

• Comparing low-dose buccal buprenorphine to standard opioids for pain relief and abuse potential

  This study is testing if a low-dose form of buprenorphine can relieve pain and has less potential for abuse compared to the standard opioid oxycodone, using healthy volunteers.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05988710

• Using remote guidance to improve regional anesthesia training

  This study tests whether using real-time remote guidance from expert anesthesiologists can help train doctors in ultrasound-guided regional anesthesia techniques to improve patient safety and satisfaction.

  Recruiting Queen's University · Kingston, Ontario · NCT05968261

• Examining pain relief mechanisms after lumbar nerve blocks

  This study is testing how well lumbar nerve blocks can relieve chronic low back pain and how the body's nervous system affects that relief in patients who are about to receive the treatment.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05961800

• Pain relief for patients undergoing jaw surgery

  This study is testing if nerve blocks can help reduce pain for patients having jaw surgery, especially those with jaw fractures, during their recovery.

  Recruiting Mansoura University · Al Mansurah, Mansoura · NCT05925465

• Comparing Dexmedetomidine and Magnesium Sulphate for Pain Relief After Thoracotomy

  This study is testing whether adding dexmedetomidine or magnesium to a common pain medication can help people feel less pain after thoracotomy surgery.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT05851768

• Comparing dexmedetomidine and dexamethasone for pain relief in thyroid surgery

  This study is testing whether adding dexmedetomidine or dexamethasone to a pain relief shot helps people having thyroid surgery feel less pain and recover faster.

  Recruiting Phase 4 Damanhour Teaching Hospital · Damanhūr, El-Beheira · NCT05793060

• Using ear stimulation to treat chronic pain and opioid withdrawal

  This study is testing whether a device that stimulates nerves around the ear can help people with chronic pain and those going through opioid withdrawal feel better.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT05555485

• Dose of bupivacaine needed for pain relief in labor with lidocaine test dose

  This trial tests the amount of bupivacaine needed to give initial comfortable pain relief for laboring women who receive a lidocaine test dose before an epidural.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05543694

• Testing a new method to relieve pain using nerve stimulation and naloxone

  This study is testing a new way to relieve pain using nerve stimulation and a medication called naloxone to see if it helps people feel better without relying on opioids.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT05490134

• Comparing pain relief methods during breast surgery

  This study is testing different ways to relieve pain during breast surgery for cancer patients to see which method works best.

  Recruiting National Cancer Institute, Egypt · Cairo, Cairo Governorate · NCT05361837

• Comparing two methods for surfactant administration in preterm infants

  This study is testing a new way to give surfactant to preterm infants with breathing problems to see if it helps them breathe better and feel less pain compared to the usual method.

  Recruiting Karolinska Institutet · Stockholm · NCT04445571

• Using electrical stimulation to manage pain after cesarean delivery

  This study is testing if a device that uses electrical stimulation can help women manage pain after having a cesarean delivery better than a placebo.

  Recruiting Hawaii Pacific Health · Honolulu, Hawaii · NCT04399707

• Serratus plane block to reduce pain during pleural drainage in the ICU.

  This study will test whether a serratus plane nerve block with lidocaine reduces pain for awake adults in the ICU who need pleural drainage.

  Recruiting Phase 3 Centre Hospitalier Universitaire, Amiens · Amiens · NCT03984656

• Analyzing patient outcomes after bariatric surgery

  This study looks at how patients feel and recover after bariatric surgery to see if certain factors can predict their pain and quality of life in the years following the procedure.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT03490630

• Analyzing genetic factors affecting pain after surgery

  This study is trying to see if certain genes can help explain why some people have more pain after surgery than others, to improve pain management for those patients.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT03489499

• Using music to reduce anxiety and pain during surgery

  This study tests if listening to music can help reduce anxiety and pain for people having surgery.

  Recruiting KK Women's and Children's Hospital · Singapore · NCT03415620

• Analyzing genetic factors affecting surgery outcomes

  This study is trying to see how genetic differences might affect the recovery and complications people experience after elective surgery.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT02124499

NIH-funded research (newest 40 of 42)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immune and nerve signals behind acupuncture relief for sickle cell pain

  This NIH grant explores how acupuncture helps reduce pain and opioid use for people with sickle cell disease.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11595810

• Personalized pain prevention around surgery

  This project tests ways to tailor pain-prevention treatments for people having surgery to reduce the chance of long-lasting post-surgical pain.

  NIH research Stanford University · Stanford, United States · NIH-11477963

• Pain sensitivity, alcohol analgesia, and heavy drinking in people with opioid use disorder

  A short, patient-friendly look at how pain sensitivity and alcohol’s pain-relieving effects might influence heavy drinking in people with opioid use disorder.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11461099

• Long-term activation of the body's own pain-relief system in the spinal cord and brainstem

  A study at the University of Pittsburgh will test how the body's natural opioid system can stay active for a long time after pain or opioid exposure, with potential implications for better pain control.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11429566

• Personalized perioperative pain prevention for high-risk patients

  A research program at Stanford is exploring why some people have long-lasting pain after surgery and how to prevent it in patients who are most at risk.

  NIH research Stanford University · Stanford, United States · NIH-11398276

• Sickle Cell Disease Pain Analgesia and Integrative Network for Better Pain Care

  A national network is being built to better understand and manage pain in adults with sickle cell disease using integrative, whole-health approaches.

  NIH research University of California-Irvine · Irvine, United States · NIH-11397510

• Weighting real-world data to understand opioid tapering outcomes in people with chronic pain and substance use disorders

  A real-world study will create and test statistical weights to better understand how tapering opioids works for patients who have chronic pain and substance use disorders.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11394597

• Targeting peripheral pain signals with DOR-KOR heteromer activating drugs

  A study to find small drug-like molecules that selectively turn on a specific peripheral pain target (DOR-KOR heteromer) to stop pain without the dangerous brain-side effects of typical opioids.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11365874

• Opioid tapering outcomes for people with chronic pain and substance use disorder

  Using medical records from many hospitals, this project looks at what happens when opioids are reduced for people who have chronic pain and also a substance use disorder.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11364654

• Targeted degradation of Nav1.8 for pain relief

  A new, targeted approach aims to reduce Nav1.8 channels in nerves to relieve chronic pain in patients, with a focus on Veterans who often struggle with painful conditions.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11346270

• Targeting OPRM1 exon 7 variants to reduce opioid side effects without reducing pain relief

  Aims to block certain gene variants that cause side effects from common opioid meds while keeping their pain relief.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11326813

• Hypocretin blocker approach to safer opioid relief

  A study exploring a new way to give strong pain relief with opioids while lowering the risk of addiction by targeting hypocretin signals.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11325692

• Stem cell protein MIF to reduce tooth and facial pain

  This project tests whether a protein released by dental stem cells (MIF) can calm nerve signals and reduce tooth‑related facial pain for people with infected teeth (apical periodontitis).

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11259457

• Long-lasting, non-addictive implant for pain after surgery

  This project offers a one-time injectable implant that slowly releases a local anesthetic to help people recovering from oral and facial surgery have longer-lasting, non‑addictive pain relief.

  NIH research University of Kentucky · Lexington, United States · NIH-11257347

• Investigating new targets to reduce side effects of pain medications without affecting pain relief

  This study is looking at how certain genetic differences can help make pain medications like fentanyl and oxycodone safer by reducing side effects and the risk of addiction, which could lead to better pain relief options for patients in the future.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11195091

• Sickle cell pain integrative care network

  This project will build a network to create and share integrative, whole‑health approaches to help reduce pain and opioid use in adults with sickle cell disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11184419

• Steroid-like anesthetics to reduce pain after surgery

  Developing steroid-like anesthetic medicines that target nerve calcium channels to relieve pain for people recovering from surgery.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11182716

• Investigating how sleep disruption affects pain relief and opioid use risk.

  This study is looking at how trouble sleeping might lead to more pain and problems with using pain medications, and it's for people who want to understand how their sleep affects their pain and medication use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11140118

• Finding New Ways to Relieve Pain Without Addiction

  This work looks for new pain relief medicines that target specific pain-sensing nerves in the body, aiming to avoid the dangerous side effects of current opioid drugs.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11137130

• Understanding the body's natural pain relief system

  This research explores how our body's natural pain-fighting chemicals work in a specific brain area to help manage chronic pain.

  NIH research Washington University · Saint Louis, United States · NIH-11127770

• Improving Nerve Stimulation for Chronic Pain Relief

  This work aims to create a smart system that can automatically adjust nerve stimulation to better relieve chronic pain.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11124680

• A new implant for long-lasting pain relief without addiction

  This study is testing a new implant that can provide pain relief directly where you had surgery, helping to manage your pain for up to a week without relying on traditional painkillers, which can be addictive, especially for patients having oral facial surgery.

  NIH research University of Kentucky · Lexington, United States · NIH-11117284

• Using hypocretin antagonism to manage pain and reduce addiction risk

  This study is exploring a new way to help people with severe pain using opioids while trying to reduce the chances of becoming addicted, by looking at how certain brain cells called hypocretin neurons affect pain and addiction.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11092882

• Understanding how pain and breathing are connected in the brain

  This study is looking at how pain and breathing affect each other, especially when using opioids for pain relief, and aims to find safer ways to manage pain without making it hard to breathe.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11055384

• Understanding how brain circuits affect pain relief and addiction from opioids

  This study is looking at how certain brain pathways affect the pain relief and addictive qualities of opioids, using mice to help find ways to manage pain better without the risk of becoming addicted.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11018599

• Understanding how the brain processes pain and natural pain relief

  This study is looking at how our brains handle pain and how our bodies can help ease it, with the goal of finding new, safer ways to manage pain without using opioids.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11000645

• Investigating how a specific factor from stem cells can reduce dental pain.

  This study is looking at how special stem cells from teeth might help reduce dental pain caused by infections, and it's for anyone suffering from tooth pain who wants to know if new treatments could make a difference.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10992784

• How the body's natural pain relief system affects pain management

  This study is looking at how the body's natural painkillers work in a part of the brain that helps control pain, with the hope of finding better ways to manage pain for people dealing with chronic pain after nerve injuries.

  NIH research Washington University · Saint Louis, United States · NIH-10990789

• Understanding how the brain's opioid circuits affect pain and pain relief.

  This study is looking at how certain brain circuits help us feel and manage pain, especially for people with chronic pain, to find new ways to relieve pain without relying on opioids.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10950050

• Creating a network to improve pain management in sickle cell disease

  This study is all about helping people with sickle cell disease by finding better ways to understand and manage their pain, bringing together experts and community members to work on new solutions that can improve their daily lives.

  NIH research University of California-Irvine · Irvine, United States · NIH-10940418

• Understanding how alcohol affects pain relief in mice

  This study is looking at how certain genes in mice affect the way alcohol can help relieve pain, which could give us insights into how alcohol might be used for pain management in people.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10938304

• Creating a system to help doctors use regional anesthesia for hip fracture pain without opioids

  This study is working on a new ultrasound tool to help doctors give better pain relief to patients with hip fractures, making it easier for them to find the right spots to inject anesthesia and reducing the need for strong pain medications.

  NIH research Rivanna Medical, INC. · Charlottesville, United States · NIH-10927446

• Finding new ways to relieve pain without dangerous side effects

  This study is exploring new ways to relieve pain without the harmful side effects of opioids, aiming to find safer treatments that work directly on the nerves that sense pain, so people can feel better without the risk of addiction.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10914772

• Understanding and preventing persistent pain after surgery

  This study is looking into why some people have ongoing pain after surgery while others don’t, and it aims to find ways to help prevent that long-lasting pain so everyone can recover better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10892778

• Understanding how stress affects pain relief mechanisms in the brain

  This study is looking at how stress affects the brain's ability to manage pain, especially for people dealing with chronic pain and stress, to help find better treatments for them.

  NIH research Washington University · Saint Louis, United States · NIH-10884233

• Using electrical stimulation to improve pain management

  This study is exploring a new way to help people with chronic pain by using a special device that sends electrical signals to nerves, adjusting the treatment based on how your body responds, so you can get better relief with fewer side effects from medications.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10876936

• Improving sedation and pain management for critically ill children

  This study is looking at how to give the right amount of medicine to help kids feel less pain and anxiety during tough medical procedures, so they can recover better and stay safe while getting the care they need.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10802191

• Gene therapy to reduce chronic pain without opioids

  This study is exploring a new gene therapy that aims to help people with chronic knee pain by delivering a special gene to nerve cells, which could provide lasting relief similar to strong pain medications but without the risks of opioids.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10710264

• Investigating how repeated CBD use affects cannabis addiction and pain relief

  This study is looking at how different amounts of CBD can affect the experience of smoking cannabis and help with pain relief for healthy adults who already use cannabis.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10663671

• Investigating how a brain circuit affects anesthesia and pain relief

  This study is looking at how a part of the brain that helps control sleep and wakefulness can be used to make anesthesia safer and more comfortable, especially by finding ways to help people recover better and feel less pain after surgery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10651642

Related topics

Quick answers

How many Analgesia clinical trials are recruiting right now?

57, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in Egypt (13 trials), United States (10 trials), Turkey (Türkiye) (8 trials), Switzerland (4 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7, Phase 2: 1, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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