Investigating a new chemokine to reduce pain after surgery
Explore the role of a new chemokine to alleviate postoperative pain
This study is looking at how a substance called CCL12 affects pain after surgery, and by blocking it, researchers hope to find a way to reduce pain without the side effects of opioids, making recovery easier for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11110017 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific immune mediator, CCL12, influences pain following surgical procedures. By neutralizing CCL12, the researchers aim to alleviate postoperative pain without the side effects associated with traditional opioid medications. The study will utilize two clinically relevant pain models to test the effectiveness of this approach and explore the underlying mechanisms of how CCL12 induces pain. If successful, this research could lead to safer pain management strategies for patients recovering from surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are scheduled for surgery and may experience postoperative pain.
Not a fit: Patients who do not undergo surgical procedures or who have chronic pain unrelated to surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer alternative to opioids for managing postoperative pain.
How similar studies have performed: While the specific role of CCL12 in pain management has not been previously investigated, targeting immune mediators has shown promise in other pain-related research.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Laumet, Geoffroy O — Michigan State University
- Study coordinator: Laumet, Geoffroy O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.