Comparing dexmedetomidine and bupivacaine for pain management after brain surgery
Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy
NA · Ain Shams University · NCT06993922
This study is testing if adding dexmedetomidine to bupivacaine can help reduce pain better after brain surgery compared to using bupivacaine alone.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ain Shams University (other) |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06993922 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of dexmedetomidine as an adjuvant to bupivacaine in scalp block versus bupivacaine alone for managing postoperative pain in patients undergoing craniotomy. The approach utilizes scalp block as a multimodal strategy to alleviate pain and reduce hemodynamic responses during surgery. By incorporating dexmedetomidine, a selective alpha-2 adrenergic receptor agonist, the study aims to enhance the analgesic effects and prolong the duration of action of local anesthetics.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 years undergoing elective supratentorial craniotomies with ASA physical status I or II.
Not a fit: Patients with a history of allergy to the study medications, bleeding disorders, or those requiring emergency craniotomy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve postoperative pain management for patients undergoing craniotomy.
How similar studies have performed: Previous studies have shown promising results with the use of dexmedetomidine as an adjuvant in pain management, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I or II. * Undergoing supratentorial elective planned craniotomies. Exclusion Criteria: * Patients refusal. * History of known allergy to the used local anesthetic or dexmedetomidine. * Bleeding disorders. * Evidence of local infection at the site of injection. * Emergency craniotomy. * Psychotic disorder. * Patients who will not be extubated in the operating room after surgery.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (RECRUITING)
Study contacts
- Study coordinator: Omar A Khiralla, MBBCH
- Email: Omar-Ahmed@med.asu.edu.eg
- Phone: 00201095281838
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Dexmedetomidine, Adjuvant, Bupivacaine, Scalp Block, Postoperative Pain, Craniotomy