Scalp nerve blocks plus dexmedetomidine to reduce opioids after brain tumor surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled study using a 2x2 factorial design to test two non-opioid strategies in adults undergoing elective supratentorial tumor resection. Participants are assigned to receive either active scalp nerve blocks, active dexmedetomidine infusion, both, or neither, with outcomes comparing opioid use and delirium incidence. The study plans to enroll 2000 patients at a single center in Beijing, with strict eligibility and safety criteria. The design aims to determine the individual and combined effects of these non-opioid analgesic approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged from 18 to 65 years
* American Society of Anesthesiologists physical status I to III
* Scheduled to undergo elective supratentorial tumor resection

Exclusion Criteria:

* Incision-area skin infection
* A history of previous craniotomy
* Allergy to study medications
* A history of preoperative change in consciousness or cognitive function
* Inability to communicate,
* Preoperative pain in the surgical region
* Severe hepatic or renal dysfunction
* Severe bradycardia (heart rate\<40 beats/min)
* Sick sinus syndrome or second- to-third degree atrioventricular block

Where it's running

• Beijing Tian Tan Hospital, Capital Medical University
  Beijing, China Recruiting

Study contacts

• Principal investigator: Yuming Peng, Dr — Beijing Tiantan Hospital
• Study coordinator: Min Zeng, Dr
• Email: fly800727@163.com
• Phone: 8610-59976658

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Analyzing genetic factors affecting pain after surgery

  This study is trying to see if certain genes can help explain why some people have more pain after surgery than others, to improve pain management for those patients.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT03489499

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.