Hemostatic methods in partial pulpotomy: sodium hypochlorite vs chlorhexidine vs cold saline
The Effect of Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain: A Randomized Clinical Trial
NA · Cukurova University · NCT07058727
This trial will try whether using 2.5% sodium hypochlorite, chlorhexidine, or cold saline to stop bleeding during partial pulpotomy changes post-procedure pain and whether the pulp remains healthy over 12 months.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 15 Years to 55 Years |
| Sex | All |
| Sponsor | Cukurova University (other) |
| Locations | 1 site (Adana, Sarıçam) |
| Trial ID | NCT07058727 on ClinicalTrials.gov |
What this trial studies
This is a randomized, single-center clinical comparison of three hemostatic agents used during partial pulpotomy for permanent teeth with carious pulp exposure. Participants are randomly assigned to receive 2.5% sodium hypochlorite, chlorhexidine, or cold saline to control bleeding, and pain is recorded using VAS scores at 1, 3, and 7 days. Pulp survival is determined by clinical examination and radiographs at 6 and 12 months. The trial excludes patients with systemic conditions affecting healing, pregnant individuals, and teeth with non-vital pulps or periapical radiolucency.
Who should consider this trial
Good fit: Adults with permanent teeth that have carious pulp exposure, no spontaneous pain, a positive cold vitality test, and no periapical radiolucency are ideal candidates.
Not a fit: Patients with non-vital or necrotic pulps, systemic diseases affecting healing, or who are pregnant are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the trial could identify the simplest and most effective bleeding control method to reduce pain and improve pulp survival after partial pulpotomy.
How similar studies have performed: Similar hemostatic approaches have been reported in the endodontic literature, but direct randomized comparisons among these three agents are limited and results have been mixed, with some data favoring sodium hypochlorite.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Permanent teeth with carious pulp exposure (no spontaneous pain). * Positive vitality test (Endo-Ice). * No periapical radiolucency. Exclusion Criteria: * Systemic diseases affecting healing. * Pregnancy. * Non-vital pulp/necrosis
Where this trial is running
Adana, Sarıçam
- Çukurova Üniversitesi Diş Hekimliği Fakültesi — Adana, Sarıçam, Turkey (Türkiye) (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Efficacy of Hemostatic Agents, Partial Pulpotomy, Postoperative Pain