Hemostatic methods in partial pulpotomy: sodium hypochlorite vs chlorhexidine vs cold saline
Official title: The Effect of Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain: A Randomized Clinical Trial
Run by Cukurova University · NCT07058727 · Data updated 2026-11-12
This trial will try whether using 2.5% sodium hypochlorite, chlorhexidine, or cold saline to stop bleeding during partial pulpotomy changes post-procedure pain and whether the pulp remains healthy over 12 months.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years to 55 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Cukurova University Academic / other |
| Locations | 1 site (Adana, Sarıçam) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | November 1, 2025 |
| Study ends | May 1, 2026 |
| Registry record updated | April 1, 2026 |
| Trial ID | NCT07058727 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with permanent teeth that have carious pulp exposure, no spontaneous pain, a positive cold vitality test, and no periapical radiolucency are ideal candidates.
✕Probably not a fit
Patients with non-vital or necrotic pulps, systemic diseases affecting healing, or who are pregnant are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, single-center clinical comparison of three hemostatic agents used during partial pulpotomy for permanent teeth with carious pulp exposure. Participants are randomly assigned to receive 2.5% sodium hypochlorite, chlorhexidine, or cold saline to control bleeding, and pain is recorded using VAS scores at 1, 3, and 7 days. Pulp survival is determined by clinical examination and radiographs at 6 and 12 months. The trial excludes patients with systemic conditions affecting healing, pregnant individuals, and teeth with non-vital pulps or periapical radiolucency.
Why it matters
Potential benefit: If successful, the trial could identify the simplest and most effective bleeding control method to reduce pain and improve pulp survival after partial pulpotomy.
How similar studies have gone: Similar hemostatic approaches have been reported in the endodontic literature, but direct randomized comparisons among these three agents are limited and results have been mixed, with some data favoring sodium hypochlorite.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Permanent teeth with carious pulp exposure (no spontaneous pain). * Positive vitality test (Endo-Ice). * No periapical radiolucency. Exclusion Criteria: * Systemic diseases affecting healing. * Pregnancy. * Non-vital pulp/necrosis
Where it's running
-
Çukurova Üniversitesi Diş Hekimliği Fakültesi
Adana, Sarıçam, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.