Preventing pain after surgery using a new treatment approach
Targeting TLR4-lipid rafts to prevent postoperative pain
['FUNDING_OTHER'] · RAFT PHARMACEUTICALS, LLC · NIH-10932172
This study is testing a new treatment called RFT1124 to help manage pain after surgery, aiming to provide relief without the side effects of traditional pain medications like opioids and NSAIDs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RAFT PHARMACEUTICALS, LLC (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-10932172 on ClinicalTrials.gov |
What this research studies
This research focuses on managing postoperative pain, which is often inadequately treated due to concerns about the side effects of traditional pain medications. The team is developing a novel treatment called RFT1124, which targets specific proteins in nerve cells and immune cells involved in pain signaling. By altering the dynamics of cholesterol in these cells, the treatment aims to reduce pain without the risks associated with common analgesics like NSAIDs and opioids. The approach has shown promise in laboratory settings, where it effectively blocked pain signals in nerve cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled for surgery who are at risk of experiencing significant postoperative pain.
Not a fit: Patients who are not undergoing surgery or those with chronic pain unrelated to surgical procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a safer and more effective way to manage postoperative pain, improving recovery and quality of life for patients.
How similar studies have performed: Other research has shown success in targeting pain pathways with innovative approaches, suggesting potential for this novel treatment.
Where this research is happening
SAN DIEGO, UNITED STATES
- RAFT PHARMACEUTICALS, LLC — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOUGHERTY, PATRICK M — RAFT PHARMACEUTICALS, LLC
- Study coordinator: DOUGHERTY, PATRICK M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.