Lignocaine versus GTN ointment for pain after hemorrhoidectomy
Official title: Role of Topical Application of Lignocaine Versus 0.2% Glyceryl Trinitrate (GTN) Ointment as a Postoperative Local Analgesic in Hemorrhoidectomy in Terms of Pain Score,Wound Healing Time and Patient Satisfaction Level
Run by King Edward Medical University · NCT07159334 · Data updated 2026-11-12
This test compares lignocaine ointment and 0.2% glyceryl trinitrate (GTN) ointment to see which provides better pain relief for adults after hemorrhoidectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 64 (estimated) |
| Sponsor | King Edward Medical University Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | August 2, 2025 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT07159334 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 with Grade III or IV hemorrhoids (ASA I–II) scheduled for hemorrhoidectomy who are not pregnant and have no allergy to lignocaine or GTN are ideal candidates.
✕Probably not a fit
Patients who are pregnant or lactating, have cardiovascular disease, take nitrates or calcium-channel blockers, have other perianal pathology requiring different surgery, or are allergic to either medication are unlikely to qualify or receive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized clinical trial at King Edward Medical University (Mayo Hospital), Lahore, will assign 64 adults undergoing Milligan-Morgan hemorrhoidectomy to receive either topical lignocaine or 0.2% GTN ointment applied postoperatively. Pain intensity will be measured at regular intervals using a visual analog scale (VAS) and wound healing will be monitored during recovery. The study compares the two topical agents for immediate postoperative analgesia and effects on wound healing and patient comfort. The overall study period is planned for about 3–6 months after protocol approval, with data collected during the postoperative follow-up.
Why it matters
Potential benefit: If successful, the preferred ointment could provide faster and better pain relief, improving comfort and recovery after hemorrhoid surgery.
How similar studies have gone: Previous smaller studies have shown that both topical lignocaine and GTN can reduce post-hemorrhoidectomy pain, but direct head-to-head comparisons are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 - 60 years * Both genders * Grade III and IV hemorrhoids diagnosed on the basis of history and clinical examination by consultant Surgeon.(Grade III Hemorrhoid manually reduced by patient with finger and Grade IV is prolapsed) * ASA (American society of Anesthesia) grades I, and II Exclusion Criteria: * Previously reported allergy or reaction to lignocaine and GTN * Pregnancy or lactation * Concomitant perianal pathology warranting surgery * Cardiovascular disease * Patient taking Nitrates or Calcium channel blocker
Where it's running
-
King Edward Medical uUniveristy Mayo Hospital
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Hafiz Ahmad Rauf — King Edward Medical University/Mayo hospital Lahore
- Study coordinator: Hafiz Ahmad Rauf, Mbbs,Fcps
- Email: ahmadrauf498@gmail.com
- Phone: +923006023465
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.