Optimal spinal morphine dose for pain after cesarean delivery
Official title: Determination of the Optimal Dose of Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Using the Up-and-Down Sequential Allocation Method
Run by University of Ioannina · NCT07023497 · Data updated 2026-11-12
This will test different doses of morphine given into the spinal fluid to find the best dose for reducing pain after an elective cesarean in adult women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | University of Ioannina Academic / other |
| Locations | 1 site (Ioannina, Epirus) |
| Status | Recruiting |
| Started | July 4, 2023 |
| Main results expected | July 1, 2026 |
| Study ends | September 1, 2026 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT07023497 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult, term parturients with a singleton pregnancy scheduled for elective cesarean delivery who are ASA II and have no history of chronic pain or opioid use.
✕Probably not a fit
Patients who are under 18, in labor, having an urgent cesarean, with chronic opioid use, serious cardiac/hepatic/renal disease, allergy to morphine, or other contraindications to spinal anesthesia are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adult women having elective, term, singleton cesarean deliveries who meet strict inclusion criteria will receive intrathecal morphine added to their spinal anesthesia at varying doses. Pain intensity, need for additional analgesics, and opioid-related side effects (for example respiratory depression, nausea, pruritus, and constipation) will be recorded in the immediate postoperative period. Participants with chronic pain, recent opioid use, urgent cesarean delivery, or contraindications to spinal anesthesia are excluded. The study is conducted at the University Hospital of Ioannina and focuses on balancing effective analgesia with minimal side effects.
Why it matters
Potential benefit: If successful, the study could identify a dose of intrathecal morphine that provides better post-cesarean pain control with fewer opioid side effects.
How similar studies have gone: Previous studies show intrathecal morphine reliably improves post-cesarean analgesia, but the optimal dose to maximize benefit while minimizing side effects remains incompletely defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * term parturient * single pregnancy * elective cesarean delivery * adult parturient * ASA II Exclusion Criteria: * participants under the age of 18 * extreme somatometric characteristics * lack of patient consent * absolute contraindications for spinal anesthesia * urgent cesarean section * presence of known fetal anomalies * onset of labor prior to administration of the block * history of chronic pain * use of opioids (systemic or otherwise) for any reason (e.g., chronic malignant pain) * communication difficulties (e.g., language barriers, cognitive impairments) * allergy or hypersensitivity to morphine * severe arrhythmia or other serious cardiovascular conditions * severe hepatic or renal insufficiency
Where it's running
-
University Hospital of Ioannina
Ioannina, Epirus, Greece Recruiting
Study contacts
- Study coordinator: Agathi Karakosta
- Email: akarakosta@uoi.gr
- Phone: +306948066243
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.