External Oblique Intercostal Plane Block to Ease Pain After Major Upper Abdominal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, assessor-blinded trial compares bilateral External Oblique Intercostal Plane Block plus standard multimodal analgesia to standard multimodal analgesia alone in adults undergoing elective major upper abdominal laparoscopic surgery. Participants receive ultrasound-guided EOIB with ropivacaine before incision, while all receive IV PCA, antiemetics, and NSAIDs per ERAS. The primary outcome is total opioid use in the first 24 hours postoperatively. The study is conducted at a single center with allocation concealment and blinded outcome assessment, aiming to establish safety and analgesic efficacy of EOIB in this surgical population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Obtain written informed consent from participants or their legal representatives
* Age between 18 and 85 years
* American Society of Anesthesiologists (ASA) physical status classification I-III
* Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery)
* Expected surgical duration ≥ 2 hours
* Ability to use the intravenous patient-controlled analgesia (IV PCA) system

Exclusion Criteria:

* Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal)
* Renal disease (serum creatinine levels ≥ 2× the upper limit of normal)
* Allergy to local anesthetics or known study-related drugs
* Pregnancy or lactation
* Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves)
* Coagulopathy or current use of anticoagulant medications
* Opioid use for more than 2 weeks in the past 6 months

Where it's running

• Fudan University Shanghai Cancer Center
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Jun Zhang, PhD
• Email: snapzhang@aliyun.com
• Phone: 0216417559001

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.