Cryotherapy to Cut Opioid Use After Knee Replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares compressive cryotherapy using the Game Ready device to standard ice packs after primary total knee arthroplasty in patients with knee osteoarthritis. The study aims to see if the cooling therapy reduces total opioid consumption in the first 7 days postoperatively and whether it improves pain and early recovery versus standard care. Participants are assigned to either the Game Ready device or traditional ice packs and receive the assigned treatment after surgery. Outcomes include analgesic use and early functional recovery, with safety monitoring as part of standard postoperative care. The trial is led by Hospital Italiano de Buenos Aires with Avanos Medical as a collaborator and is conducted at the same institution in Buenos Aires, Argentina.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 60 and 80 years
* Scheduled to undergo primary total knee arthroplasty for knee osteoarthritis
* Ability to understand the study procedures and provide written informed consent

Exclusion Criteria:

* Revision total knee arthroplasty
* Vascular disorders affecting the lower limbs
* Body mass index (BMI) greater than 35 kg/m²
* Active knee infection
* Severe preoperative limitations in knee mobility

Where it's running

• Hospital Italiano de Buenos Aires
  Buenos Aires, Buenos Aires, Argentina Recruiting

Study contacts

• Principal investigator: Igancio Garcia Mansilla, MD — Hospital Italiano de Buenos Aires
• Study coordinator: Ivan Huespe, MD
• Email: ivan.huespe@hospitalitaliano.org.ar
• Phone: +543425382554

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.