Combining a nerve block with intrathecal morphine for better pain relief after major abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In adults undergoing elective or emergency midline laparotomy, researchers compare the combination of an erector spinae plane block with intrathecal morphine to either technique alone for postoperative analgesia. The goal is to determine if the dual approach provides superior pain control and lowers opioid consumption within 48 hours after surgery. The study is interventional and involves neuraxial and regional anesthesia methods, with safety and pain outcomes monitored. Results could influence analgesic strategies for major abdominal surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria Patients scheduled to undergo elective or emergency midline exploratory laparotomy.

American Society of Anesthesiologists (ASA) physical status I, II, or III. Intact cognitive ability to comprehend study procedures, use the Numeric Rating Scale (NRS) accurately, and provide informed consent.

Exclusion Criteria Contraindications to regional or neuraxial anesthesia (e.g., patient refusal, localized infection at needle insertion sites, known coagulopathy (INR \>1.5 or platelet count \<80,000/\\mu L), or un-pausable therapeutic anticoagulation).

Known allergy or severe hypersensitivity to local anesthetics or morphine. Chronic pain conditions requiring daily opioid consumption for \>3 months preoperatively.

Documented history of substance use disorder. Severe chronic respiratory disease (e.g., COPD requiring home oxygen therapy, or severe obstructive sleep apnea not managed with CPAP).

Neurological or psychiatric conditions that compromise sensory perception or communication.

Surgical incisions planned to extend significantly past the midline. Severe spinal deformities or a history of spinal surgery at the targeted block/injection interspaces.

Concurrent enrollment in any other interventional clinical trial.

Where it's running

• Sohag University Hospital
  Sohag, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.