Tea tree oil versus chlorhexidine mouthwash after impacted lower wisdom tooth removal
Official title: The Evaluation of the Effects of Chlorhexidine and Tea Tree Oil Mouthwash on Postoperative Complications and Periodontal Healing After the Extraction of Impacted Third Molars
Run by Harran University · NCT07180498 · Data updated 2026-11-12
This tests whether tea tree oil mouthwash can reduce swelling, pain, limited mouth opening, and help gum healing as well as standard chlorhexidine in adults after extraction of impacted lower wisdom teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Harran University Academic / other |
| Locations | 1 site (Sanliurfa) |
| Status | Recruiting |
| Started | April 15, 2025 |
| Main results expected | October 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | September 18, 2025 |
| Trial ID | NCT07180498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 in generally stable health who are undergoing extraction of Class 2, Class B impacted lower third molars and who can use the assigned mouthwash are ideal candidates.
✕Probably not a fit
Patients with known allergy to tea tree oil, serious systemic illnesses (e.g., heart failure, kidney disease), bleeding disorders, pregnancy or breastfeeding, or taking interacting medications are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with Class 2, Class B impacted mandibular third molars will be enrolled and allocated to use either a tea tree oil mouthwash (3 drops in 100 mL water, three times daily) or 0.12% chlorhexidine mouthwash for 7 days after extraction. All extractions are performed by the same experienced oral surgeon under local anesthesia, with standard antibiotic (amoxicillin-clavulanate) and paracetamol prescribed postoperatively. Patients will be monitored for 7 days with measurements of facial swelling, pain, trismus, and periodontal/gum healing recorded at baseline and follow-up. The planned sample size is 54 participants (at least 27 per group) based on power calculations to detect differences in postoperative outcomes.
Why it matters
Potential benefit: If successful, tea tree oil could provide a natural alternative to chlorhexidine with similar reduction of postoperative swelling, pain, and gum complications after wisdom tooth removal.
How similar studies have gone: Laboratory and small clinical reports suggest tea tree oil has antimicrobial and anti-inflammatory effects, but few rigorous trials directly compare it with chlorhexidine after third molar extraction.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \& Gregory). * Individuals aged 18-65. * Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease). * Individuals willing to use tea tree extract or other treatments. Exclusion Criteria: * Individuals with a known allergy or hypersensitivity to tea tree extract. * Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders. * Individuals during pregnancy and breastfeeding. * Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives) * Individuals previously treated for edema. * Individuals with chronic edema.
Where it's running
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Harran University, Faculty of Dentistry
Sanliurfa, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Mine alkaya karagoz — Harran University
- Study coordinator: Mine alkaya karagoz
- Email: minekaragoz@harran.edu.tr
- Phone: 905365417606
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.