Clinical trial Recruiting at 1 site Interventional Ages 18 to 70

Dexketoprofen given by IV to see if it reduces rebound pain after shoulder block

Official title: Evaluation of the Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain in Patients Undergoing Interscalene Brachial Plexus Block

Run by Eskisehir Osmangazi University · NCT07642674 · Data updated 2026-11-12

This study tests whether giving an IV dose of dexketoprofen after shoulder surgery can lessen or prevent rebound pain when a nerve block wears off.

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Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment66 (estimated)
SponsorEskisehir Osmangazi University
Academic / other
Locations1 site (Eskişehir, Odunpazarı)
StatusRecruiting
StartedJune 11, 2026
Main results expectedJanuary 1, 2027
Study endsJanuary 1, 2027
Registry record updatedJune 12, 2026
Trial IDNCT07642674 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–70 years old undergoing arthroscopic shoulder surgery with ASA I–III, receiving interscalene block, and without NSAID contraindications or significant renal impairment.

Probably not a fit

Patients with NSAID contraindications, renal impairment, or those whose pain is not primarily driven by rebound phenomena may see no benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing rotator cuff repair receive an interscalene block and general anesthesia, then are given either standard postoperative analgesia or the same plus intravenous dexketoprofen to see if rebound pain and overall pain are reduced. The trial monitors pain scores, block efficacy, and need for rescue analgesia within the first 24 hours post-surgery. Rebound pain is defined as severe pain (VAS ≥ 7) after the block wears off, roughly 8–12 hours post-block. The study uses a standardized anesthetic protocol and includes adult patients aged 18–70 without significant renal impairment or NSAID contraindications. Primary outcomes focus on incidence and severity of rebound pain and overall analgesic consumption.

Why it matters

Potential benefit: If successful, IV dexketoprofen could reduce rebound pain and improve postoperative comfort after shoulder surgery.

How similar studies have gone: Previous work has explored NSAIDs for postoperative pain and rebound phenomena, but this specific approach with IV dexketoprofen for rebound pain is less established and exploratory.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Age 18-70 years ASA score of I-III Arthroscopic shoulder surgery

Exclusion Criteria:

Patients who do not wish to participate in the study Creatinine clearance \<50 mL/ min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated

Where it's running

  • Eskisehir Osmangazi Universıty Faculty of Medicine
    Eskişehir, Odunpazarı, Turkey (Türkiye)
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.