Dexketoprofen given by IV to see if it reduces rebound pain after shoulder block
Official title: Evaluation of the Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain in Patients Undergoing Interscalene Brachial Plexus Block
Run by Eskisehir Osmangazi University · NCT07642674 · Data updated 2026-11-12
This study tests whether giving an IV dose of dexketoprofen after shoulder surgery can lessen or prevent rebound pain when a nerve block wears off.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Eskisehir Osmangazi University Academic / other |
| Locations | 1 site (Eskişehir, Odunpazarı) |
| Status | Recruiting |
| Started | June 11, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT07642674 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–70 years old undergoing arthroscopic shoulder surgery with ASA I–III, receiving interscalene block, and without NSAID contraindications or significant renal impairment.
✕Probably not a fit
Patients with NSAID contraindications, renal impairment, or those whose pain is not primarily driven by rebound phenomena may see no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients undergoing rotator cuff repair receive an interscalene block and general anesthesia, then are given either standard postoperative analgesia or the same plus intravenous dexketoprofen to see if rebound pain and overall pain are reduced. The trial monitors pain scores, block efficacy, and need for rescue analgesia within the first 24 hours post-surgery. Rebound pain is defined as severe pain (VAS ≥ 7) after the block wears off, roughly 8–12 hours post-block. The study uses a standardized anesthetic protocol and includes adult patients aged 18–70 without significant renal impairment or NSAID contraindications. Primary outcomes focus on incidence and severity of rebound pain and overall analgesic consumption.
Why it matters
Potential benefit: If successful, IV dexketoprofen could reduce rebound pain and improve postoperative comfort after shoulder surgery.
How similar studies have gone: Previous work has explored NSAIDs for postoperative pain and rebound phenomena, but this specific approach with IV dexketoprofen for rebound pain is less established and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age 18-70 years ASA score of I-III Arthroscopic shoulder surgery Exclusion Criteria: Patients who do not wish to participate in the study Creatinine clearance \<50 mL/ min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated
Where it's running
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Eskisehir Osmangazi Universıty Faculty of Medicine
Eskişehir, Odunpazarı, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Çağla Uzalp
- Email: caglauzalp@gmail.com
- Phone: 02222392979
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.