Serratus posterior superior intercostal plane block for pain control after off-pump minimally invasive CABG
Off-pump Minimal Invaziv Koroner Arter Bypass Cerrahisi geçiren Hastalarda Serratus Posterior Superior Interkostal Plan Blokunun Analjezik etkinliği: Randomize kontrollü çalışma
This trial will test whether an ultrasound-guided serratus posterior superior intercostal plane block with bupivacaine reduces postoperative pain in adults having elective off-pump minimally invasive coronary artery bypass grafting.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Kartal Kosuyolu High Speciality Training and Research Hospital Government |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07412522 on ClinicalTrials.gov |
What this trial studies
This prospective, randomized study will enroll about 60 adults scheduled for elective off-pump minimally invasive CABG and randomize them to receive an ultrasound-guided serratus posterior superior intercostal plane block (SPSIPB) with bupivacaine or standard analgesic care. The SPSIPB is a fascial plane block intended to provide wide thoracic dermatomal coverage and is performed under ultrasound guidance. Primary outcomes include postoperative pain scores and opioid consumption during the immediate postoperative period, with other clinical outcomes and complications recorded. The protocol emphasizes opioid-sparing analgesia consistent with Enhanced Recovery After Surgery recommendations.
Who should consider this trial
Good fit: Adults aged 18–75 years with ASA physical status II–III who are scheduled for elective off-pump minimally invasive CABG and can give informed consent are ideal candidates.
Not a fit: Patients with coagulation disorders or incompatible anticoagulation, chronic opioid dependence, severe pulmonary disease, active infection at the injection site, or those who require conversion to on-pump CABG or sternotomy are unlikely to benefit from this block in the trial context.
Why it matters
Potential benefit: If successful, the block could reduce postoperative pain and opioid use after minimally invasive off-pump CABG, potentially lowering opioid-related side effects and pulmonary complications.
How similar studies have performed: Related ultrasound-guided fascial plane blocks have shown benefit in thoracic and cardiac surgery analgesia, but the serratus posterior superior intercostal plane block is a recently described technique with limited dedicated trial data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-75 years * ASA physical status II-III * Scheduled for elective off-pump minimally invasive coronary artery bypass grafting (CABG) surgery * Ability to understand and use the Numerical Rating Scale (NRS) * Ability to provide written informed consent Exclusion Criteria: * Refusal to participate in the study * Known allergy or contraindication to local anesthetics * Coagulation disorders or ongoing anticoagulant therapy incompatible with regional anesthesia * Infection at the block injection site * Severe hepatic or renal dysfunction * Chronic opioid use or opioid dependence * History of chronic pain syndromes * Severe pulmonary disease (e.g., advanced COPD) * Neurological or psychiatric disorders that may interfere with pain assessment * Emergency surgery * Conversion to on-pump CABG or sternotomy during surgery
Where this trial is running
Istanbul
- Kosuyolu High Specialization Training and Research Hospital — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Mustafa Burgaç, himself — mustafaburgac@outlook.com
- Study coordinator: Mustafa Burgaç, himself
- Email: mustafaburgac@gmail.com
- Phone: 538 984 8198
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.