Comparing two methods of pain control after kidney surgery in cancer patients
Efficacy of Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block (Ql4) Versus Bilateral Lateral Quadratus Lumborum Plane Block (Ql1) in Controlling Post-Operative Pain in Cancer Patient Undergoing Open Nephrectomy: A Randomized Control Study
This study is testing two different ways to control pain after kidney surgery in cancer patients to see which method works better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | National Cancer Institute, Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06889987 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two different techniques for administering quadratus lumborum plane blocks to manage postoperative pain in cancer patients undergoing open nephrectomy. The two methods being compared are the bilateral ultrasound-guided intramuscular quadratus lumborum plane block and the bilateral lateral quadratus lumborum plane block. By assessing pain relief and potential complications, the study aims to determine which technique provides better outcomes for patients. The research is conducted at the National Cancer Institute in Cairo, Egypt.
Who should consider this trial
Good fit: Ideal candidates for this study are cancer patients aged 18 to 65 who are undergoing unilateral open nephrectomy and have an ASA physical status of II-III.
Not a fit: Patients with contraindications to regional anesthesia, chronic pain syndromes, or those on chronic analgesic therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for cancer patients undergoing kidney surgery.
How similar studies have performed: Previous studies have shown promising results with quadratus lumborum blocks for pain management, indicating that this approach is gaining traction in clinical practice.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status II-III. * Body mass index (BMI): (20- 40) kg/m2. * Type of surgery: midline incision for unilateral open nephrectomy. Exclusion Criteria: * Patient refusal. * Age \<18 years or \>65 years * BMI \<20 kg/m2 and \> 40 kg/m2 * Known sensitivity or contraindication to drugs used in the study * Contraindication to regional anesthesia, e.g. local infection at the introduction site, pre-existing peripheral neuropathies and coagulopathy. * Physical status ASA IV * Patients on chronic analgesic therapy (daily morphine ≥30 mg or equivalent dose of other opioids or tramadol or any medication for neuropathic pain) * Patients with a history of drug abuse * Patients with neuropsychiatric diseases; patients with a history of chronic pain syndromes that may enhance sensitivity to pain, for example, fibromyalgia * All patients who are going to have severe intra- or post-operative bleeding or will require postoperative mechanical ventilation are also excluded from the study.
Where this trial is running
Cairo
- National Cancer Institute — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed M Salama, Master
- Email: dr.Ahmed.ismail93@gmail.com
- Phone: 00201024275085
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.