Liposomal Bupivacaine vs Ropivacaine for TAP Block in Laparoscopic Gallbladder Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, single-blind study comparing two local anesthetic options for the transversus abdominis plane (TAP) block during laparoscopic cholecystectomy. Participants are randomly assigned to receive either liposomal bupivacaine or ropivacaine for the TAP block, with the primary outcome being the dynamic pain score at 24 hours post-surgery. Secondary outcomes include pain scores at multiple time points, recovery quality, time to first rescue analgesia, analgesic use, return of gastrointestinal function, length of hospital stay, and adverse events, plus follow-up at 3 months for chronic postsurgical pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65 years, either gender.
* Patients scheduled for elective laparoscopic cholecystectomy.
* ASA physical status I-III.
* Able to provide written informed consent and complete the 3-month follow-up.

Exclusion Criteria:

* History of allergy to local anesthetics.
* History of dementia, psychosis, or other central nervous system diseases.
* History of chronic pain or long-term use of opioids or other analgesics.
* Contraindications to nerve block: infection at puncture site, severe coagulopathy.
* Severe hepatic or renal dysfunction, pregnancy, or lactation.

Where it's running

• Tianjin First Central Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Ke yu Zhang
• Email: m456365zky@163.com
• Phone: +86 19861121816

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.