Subcostal TAP Block and EEG Changes During Laparoscopic Gallbladder Surgery
Official title: Effect of Subcostal Transversus Abdominis Plane Block on Analgesia, EEG Dynamics, and Burst Suppression in Laparoscopic Cholecystectomy
Run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · NCT07818954 · Data updated 2026-11-12
This observational study tests whether adding a subcostal TAP block to standard IV opioid therapy affects intraoperative brain activity measures and pain needs in adults undergoing laparoscopic cholecystectomy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | July 15, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT07818954 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older undergoing laparoscopic cholecystectomy under general anesthesia, ASA I–III, who consent to participate.
✕Probably not a fit
Patients with ASA IV–V or those who do not receive the TAP block may not experience any detectable benefit from the intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center observational study at Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital. Adult patients undergoing laparoscopic cholecystectomy under general anesthesia are grouped by analgesic technique chosen in routine care: remifentanil alone or remifentanil with an ultrasound-guided subcostal TAP block. The study records intraoperative analgesic use, BIS values, EEG dynamics, and burst suppression, and compares these metrics between groups. Postoperative outcomes such as pain scores, additional analgesic requirements, and recovery metrics are collected. Depth of anesthesia is monitored per standard practice, and data are analyzed to explore associations between TAP block use, analgesic needs, and cerebral electrical activity.
Why it matters
Potential benefit: If successful, the study could clarify whether a subcostal TAP block reduces intraoperative analgesic needs and modulates brain activity patterns during laparoscopic surgery, potentially guiding anesthesia strategies.
How similar studies have gone: Previous work in regional analgesia and intraoperative EEG/BIS monitoring suggests potential benefits, but this specific combination in laparoscopic cholecystectomy is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * American Society of Anesthesiologists (ASA) physical status I-III * Scheduled to undergo laparoscopic cholecystectomy under general anesthesia * Written informed consent provided by the participant or, when applicable, the legally authorized representative Exclusion Criteria: * Refusal to participate in the study * American Society of Anesthesiologists (ASA) physical status IV-V * Known allergy or hypersensitivity to medications used during perioperative anesthetic or analgesic management
Where it's running
-
Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.